MAD2L2 and ADAM17

Number of citations of the paper that reports this interaction (PubMedID 10527948)
50

Data Source:
HPRD (in vitro, in vivo)

		MAD2L2	ADAM17
Description		mitotic arrest deficient 2 like 2	ADAM metallopeptidase domain 17
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Anaphase-promoting Complex Chromosome Cytoplasm Spindle Cytoskeleton Zeta DNA Polymerase Complex Site Of Double-strand Break	Golgi Membrane Cytoplasm Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Cell Surface Actin Cytoskeleton Membrane Apical Plasma Membrane Ruffle Membrane Membrane Raft
	Molecular Function	Transcription Corepressor Activity Protein Binding JUN Kinase Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Endopeptidase Activity Metalloendopeptidase Activity Notch Binding Interleukin-6 Receptor Binding Integrin Binding Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity SH3 Domain Binding Cytokine Binding PDZ Domain Binding Tumor Necrosis Factor Binding Metal Ion Binding Metallodipeptidase Activity Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Somatic Diversification Of Immunoglobulins Involved In Immune Response DNA Repair Double-strand Break Repair DNA Damage Response Actin Filament Organization Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transcription By Competitive Promoter Binding Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Protein Catabolic Process Error-prone Translesion Synthesis DNA Damage Response, Signal Transduction Resulting In Transcription Telomere Maintenance In Response To DNA Damage Positive Regulation Of Isotype Switching Positive Regulation Of DNA-templated Transcription Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Response To Hypoxia Neutrophil Mediated Immunity Germinal Center Formation Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Leukocyte Chemotaxis Proteolysis Membrane Protein Ectodomain Proteolysis Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway Notch Signaling Pathway Notch Receptor Processing Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Positive Regulation Of Signal Transduction Positive Regulation Of T Cell Chemotaxis Negative Regulation Of Neuron Projection Development Protein Processing Signal Release B Cell Differentiation Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Lipopolysaccharide Positive Regulation Of Chemokine Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Mast Cell Apoptotic Process T Cell Differentiation In Thymus Cell Adhesion Mediated By Integrin Wound Healing, Spreading Of Epidermal Cells Amyloid Precursor Protein Catabolic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Spleen Development Regulation Of Axon Regeneration Cell Motility Defense Response To Gram-positive Bacterium Cellular Response To High Density Lipoprotein Particle Stimulus Commissural Neuron Axon Guidance Negative Regulation Of Cold-induced Thermogenesis Cytokine Precursor Processing Signaling Receptor Ligand Precursor Processing Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Vascular Endothelial Cell Proliferation Regulation Of Neuron Migration
Pathways		Translesion synthesis by REV1 Translesion synthesis by POLK Translesion synthesis by POLI	Nuclear signaling by ERBB4 Collagen degradation Signaling by EGFR Regulated proteolysis of p75NTR Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Release of Hh-Np from the secreting cell TNF signaling CD163 mediating an anti-inflammatory response Growth hormone receptor signaling
Drugs			(3S)-1-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}pyrrolidine-3-thiol 3-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}propane-1-thiol 4-({4-[(4-AMINOBUT-2-YNYL)OXY]PHENYL}SULFONYL)-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDE (2R)-N-HYDROXY-2-[(3S)-3-METHYL-3-{4-[(2-METHYLQUINOLIN-4-YL)METHOXY]PHENYL}-2-OXOPYRROLIDIN-1-YL]PROPANAMIDE methyl (1R,2S)-2-(hydroxycarbamoyl)-1-{4-[(2-methylquinolin-4-yl)methoxy]benzyl}cyclopropanecarboxylate (1S,3R,6S)-4-oxo-6-{4-[(2-phenylquinolin-4-yl)methoxy]phenyl}-5-azaspiro[2.4]heptane-1-carboxylic acid N-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}-5-methyl-D-tryptophan (3S)-4-{[4-(BUT-2-YNYLOXY)PHENYL]SULFONYL}-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDE
Diseases
GWAS		Arterial stiffness (brachial-femoral pulse wave velocity) ( 32790701) Visceral adipose tissue adjusted for BMI ( 22589738)	Appendicular lean mass ( 33097823) Birth weight ( 31043758) Offspring birth weight ( 31043758)
Interacting Genes		47 interacting genes: ADAM15 ADAM17 ADAM9 CAMK2B CDC20 CDH1 CIMIP1 DEPDC5 ELK1 FAM217B FTO FZR1 GSC2 IKZF1 IKZF3 INCA1 KCTD9 KRT34 MAD2L1 MAD2L1BP MBD3L1 MYBPC2 PLAGL2 POLDIP2 PPM1B PRCC PRR5L PRRC2A RAB11FIP4 RBBP6 REL REV1 REV3L SFI1 SHLD1 TCF4 THAP6 TRIM27 TRIM54 TRIM7 YPEL3 YY1AP1 ZBED1 ZMYND12 ZNF511 ZNF558 ZNF655	13 interacting genes: DLG1 ERBB4 FHL2 MAD2L1 MAD2L2 NOTCH1 PTPN3 SH3D19 TGFA TIMP3 TNF TNFRSF1A TNFSF11
Entrez ID		10459	6868
HPRD ID		07246	04703
Ensembl ID		ENSG00000116670	ENSG00000151694
Uniprot IDs		Q9UI95	B2RNB2 P78536
PDB IDs		3ABD 3ABE 3VU7 4EXT 4GK0 4GK5 5XPT 5XPU 6BC8 6BCD 6BI7 6K07 6K08 6KEA 6KTO 6M7A 6M7B 6NIF 6VE5 6WS0 6WS5 6WW9 6WWA 7L9P	1BKC 1ZXC 2A8H 2DDF 2FV5 2FV9 2I47 2M2F 2OI0 3B92 3CKI 3E8R 3EDZ 3EWJ 3G42 3KMC 3KME 3L0T 3L0V 3LE9 3LEA 3LGP 3O64 8CQY 8SNL 8SNN 8SNO 9E6K
Enriched GO Terms of Interacting Partners?		Mitotic Checkpoint Complex Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Metal Ion Binding Translesion Synthesis Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Protein Binding Positive Regulation Of Cell Cycle Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Cell Cycle DNA Binding DNA Biosynthetic Process Postreplication Repair Error-free Translesion Synthesis Positive Regulation Of Synapse Maturation DNA Synthesis Involved In DNA Repair Anaphase-promoting Complex Binding Ubiquitin-protein Transferase Activator Activity Negative Regulation Of Type I Interferon Production Positive Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Error-prone Translesion Synthesis Regulation Of Mitotic Cell Cycle Ubiquitin Ligase Activator Activity Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle DNA-binding Transcription Factor Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Zinc Ion Binding Regulation Of Mitotic Sister Chromatid Separation Regulation Of Nuclear Division Negative Regulation Of Interferon-beta Production Positive Regulation Of Catabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Process Amyloid Precursor Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Chromosome Separation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Regulation Of Cell Cycle Phase Transition SUMO Transferase Activity Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Sister Chromatid Separation Anaphase-promoting Complex Regulation Of Metabolic Process Sequence-specific DNA Binding	Regulation Of Membrane Protein Ectodomain Proteolysis Epithelial Cell Proliferation Mammary Gland Alveolus Development Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Signal Transduction Negative Regulation Of Extracellular Matrix Organization Regulation Of Mitotic Cell Cycle Regulation Of ERK1 And ERK2 Cascade Regulation Of Mitotic Nuclear Division Negative Regulation Of Protein Catabolic Process Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Nuclear Division Regulation Of Endothelial Cell Differentiation Negative Regulation Of Extracellular Matrix Constituent Secretion Negative Regulation Of Cell Cycle Regulation Of MAPK Cascade Regulation Of Epithelial Cell Proliferation Negative Regulation Of Catabolic Process Positive Regulation Of Fever Generation Negative Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Apoptotic Process Involved In Morphogenesis Negative Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Primary Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Regulation Of Extracellular Matrix Constituent Secretion Positive Regulation Of Apoptotic Process Involved In Development Regulation Of Fever Generation Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of MAPK Cascade Negative Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Extracellular Matrix Organization Intracellular Signal Transduction Protein Localization To Cell Periphery Establishment Of Centrosome Localization Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Cell Surface Receptor Signaling Pathway Via STAT Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Heat Generation Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cell-cell Adhesion Regulation Of Macromolecule Metabolic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process
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