MAD2L2 and RAB11FIP4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MAD2L2	RAB11FIP4
Description		mitotic arrest deficient 2 like 2	RAB11 family interacting protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Anaphase-promoting Complex Chromosome Cytoplasm Spindle Cytoskeleton Zeta DNA Polymerase Complex Site Of Double-strand Break	Extracellular Space Cytoplasm Endosome Golgi Apparatus Centrosome Spindle Cytoskeleton Membrane Endocytic Vesicle Midbody Cytoplasmic Vesicle Cleavage Furrow Perinuclear Region Of Cytoplasm Recycling Endosome Membrane
	Molecular Function	Transcription Corepressor Activity Protein Binding JUN Kinase Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Calcium Ion Binding Protein Binding Small GTPase Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Somatic Diversification Of Immunoglobulins Involved In Immune Response DNA Repair Double-strand Break Repair DNA Damage Response Actin Filament Organization Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transcription By Competitive Promoter Binding Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Protein Catabolic Process Error-prone Translesion Synthesis DNA Damage Response, Signal Transduction Resulting In Transcription Telomere Maintenance In Response To DNA Damage Positive Regulation Of Isotype Switching Positive Regulation Of DNA-templated Transcription Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Neural Retina Development Endocytic Recycling Regulation Of Cytokinesis Positive Regulation Of G1 To G0 Transition
Pathways		Translesion synthesis by REV1 Translesion synthesis by POLK Translesion synthesis by POLI
Drugs
Diseases
GWAS		Arterial stiffness (brachial-femoral pulse wave velocity) ( 32790701) Visceral adipose tissue adjusted for BMI ( 22589738)	Adventurousness ( 30643258) Apolipoprotein A1 levels ( 32203549) Brain morphology (MOSTest) ( 32665545) Facial attractiveness (male raters) ( 30946739) Heel bone mineral density ( 28869591 30598549) Hip circumference adjusted for BMI ( 34021172) Keratoconus ( 33649486) Myocardial infarction ( 33532862)
Interacting Genes		47 interacting genes: ADAM15 ADAM17 ADAM9 CAMK2B CDC20 CDH1 CIMIP1 DEPDC5 ELK1 FAM217B FTO FZR1 GSC2 IKZF1 IKZF3 INCA1 KCTD9 KRT34 MAD2L1 MAD2L1BP MBD3L1 MYBPC2 PLAGL2 POLDIP2 PPM1B PRCC PRR5L PRRC2A RAB11FIP4 RBBP6 REL REV1 REV3L SFI1 SHLD1 TCF4 THAP6 TRIM27 TRIM54 TRIM7 YPEL3 YY1AP1 ZBED1 ZMYND12 ZNF511 ZNF558 ZNF655	9 interacting genes: ARF6 ECPAS GFI1B MAD2L2 PKNOX1 RAB11A RAB11FIP2 RAB11FIP3 RAB11FIP5
Entrez ID		10459	84440
HPRD ID		07246	11466
Ensembl ID		ENSG00000116670	ENSG00000131242
Uniprot IDs		Q9UI95	Q86YS3
PDB IDs		3ABD 3ABE 3VU7 4EXT 4GK0 4GK5 5XPT 5XPU 6BC8 6BCD 6BI7 6K07 6K08 6KEA 6KTO 6M7A 6M7B 6NIF 6VE5 6WS0 6WS5 6WW9 6WWA 7L9P
Enriched GO Terms of Interacting Partners?		Mitotic Checkpoint Complex Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Metal Ion Binding Translesion Synthesis Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Protein Binding Positive Regulation Of Cell Cycle Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Cell Cycle DNA Binding DNA Biosynthetic Process Postreplication Repair Error-free Translesion Synthesis Positive Regulation Of Synapse Maturation DNA Synthesis Involved In DNA Repair Anaphase-promoting Complex Binding Ubiquitin-protein Transferase Activator Activity Negative Regulation Of Type I Interferon Production Positive Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Error-prone Translesion Synthesis Regulation Of Mitotic Cell Cycle Ubiquitin Ligase Activator Activity Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle DNA-binding Transcription Factor Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Zinc Ion Binding Regulation Of Mitotic Sister Chromatid Separation Regulation Of Nuclear Division Negative Regulation Of Interferon-beta Production Positive Regulation Of Catabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Process Amyloid Precursor Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Chromosome Separation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Regulation Of Cell Cycle Phase Transition SUMO Transferase Activity Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Sister Chromatid Separation Anaphase-promoting Complex Regulation Of Metabolic Process Sequence-specific DNA Binding	Protein Localization To Cleavage Furrow Recycling Endosome Membrane Positive Regulation Of Mitotic Cytokinetic Process Positive Regulation Of Mitotic Cytokinesis Regulation Of Mitotic Cytokinesis Recycling Endosome Positive Regulation Of Cilium Assembly Endosome Vesicle Docking Involved In Exocytosis Positive Regulation Of Cytokinesis Regulation Of Early Endosome To Recycling Endosome Transport Negative Regulation Of Adiponectin Secretion Protein Localization To Plasma Membrane Early Endosome To Recycling Endosome Transport Cleavage Furrow Vesicle Docking Protein Localization To Cilium Regulation Of Cell Projection Assembly Mitotic Cytokinesis Protein Localization To Cell Periphery Positive Regulation Of Protein Localization To Plasma Membrane Endocytic Vesicle Positive Regulation Of Protein Localization To Cell Periphery Protein Transport Endocytic Recycling Organelle Localization By Membrane Tethering Regulation Of Cytokinesis Small GTPase Binding Positive Regulation Of Protein Localization To Membrane Membrane Docking Positive Regulation Of Cell Division Cytoskeleton-dependent Cytokinesis Establishment Of Cell Polarity Protein Localization To Membrane Regulation Of Protein Localization To Centrosome Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Organelle Assembly Regulation Of Cilium Assembly Establishment Of Protein Localization Regulation Of Cell Cycle Process Positive Regulation Of Cell Projection Organization Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Protein Localization To Plasma Membrane Vesicle-mediated Transport To The Plasma Membrane Regulation Of Endocytic Recycling Regulation Of Protein Transport Establishment Of Localization In Cell Regulation Of Protein Localization To Cell Periphery Regulation Of Protein Localization Establishment Or Maintenance Of Cell Polarity
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