MAD2L2 and ADAM15

Number of citations of the paper that reports this interaction (PMID 10527948)
12

Data Source:
BioGRID (two hybrid)

		MAD2L2	ADAM15
Gene Name		MAD2 mitotic arrest deficient-like 2 (yeast)	ADAM metallopeptidase domain 15
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Spindle Zeta DNA Polymerase Complex	Acrosomal Vesicle Plasma Membrane Adherens Junction Cell Surface Integral Component Of Membrane Cell Projection Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Activating Transcription Factor Binding Protein Binding JUN Kinase Binding	Metalloendopeptidase Activity Integrin Binding Protein Binding Metallopeptidase Activity Zinc Ion Binding SH3 Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Growth DNA Repair Double-strand Break Repair Transcription, DNA-templated Actin Filament Organization Mitotic Nuclear Division Mitotic Spindle Assembly Checkpoint Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transcription By Competitive Promoter Binding Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Protein Catabolic Process DNA Damage Response, Signal Transduction Resulting In Transcription Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Transcription, DNA-templated Cell Division Negative Regulation Of APC-Cdc20 Complex Activity Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Transcription Regulatory Region DNA Binding	Angiogenesis Negative Regulation Of Cell-matrix Adhesion Proteolysis Apoptotic Process Cell-matrix Adhesion Integrin-mediated Signaling Pathway Extracellular Matrix Disassembly Extracellular Matrix Organization Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Collagen Catabolic Process Tissue Regeneration Innate Immune Response Cardiac Epithelial To Mesenchymal Transition Protein Kinase C Signaling Negative Regulation Of Receptor Binding
Pathways		Translesion synthesis by Pol zeta DNA Damage Bypass Translesion synthesis by DNA polymerases bypassing lesion on DNA template	Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Visceral adipose tissue adjusted for BMI ( 22589738)	Prostate cancer ( 23535732)
Protein-Protein Interactions		22 interactors: ADAM15 ADAM17 ADAM9 CAMK2B CDC20 CDH1 ELK1 IKZF1 KCTD9 MAD2L1 POLDIP2 PRCC PRRC2A RBBP6 REL REV1 REV3L SFI1 TCF4 TRIM27 TRIP13 YY1AP1	32 interactors: ABL1 ARHGEF6 ARHGEF7 BANP FHL3 FYN GRB2 HCK LCK LYN MAD2L2 NCK1 NPHP1 NUP62 PACSIN3 RBPMS SH3D19 SH3GL2 SH3GLB1 SH3PXD2A SH3RF1 SH3RF3 SNX30 SNX33 SNX9 SORBS1 SORBS2 SORBS3 SP4 SRC TRIP13 YES1
Entrez ID		10459	8751
HPRD ID		07246	05674
Ensembl ID		ENSG00000116670	ENSG00000143537
Uniprot IDs		Q9UI95	B4DMH8 Q13444 U3KQL5
PDB IDs		3ABD 3ABE 3VU7 4EXT 4GK0 4GK5
Enriched GO Terms of Interacting Partners?		Cell Cycle Cell Cycle Process Regulation Of Cell Cycle Mitotic Cell Cycle Process Extracellular Matrix Disassembly PMA-inducible Membrane Protein Ectodomain Proteolysis Mitotic Cell Cycle Error-prone Translesion Synthesis Response To Stress Regulation Of Meiosis Regulation Of Meiotic Cell Cycle Activation Of Anaphase-promoting Complex Activity Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Cellular Component Organization Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Collagen Catabolic Process Negative Regulation Of Ubiquitin-protein Transferase Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Translesion Synthesis Cell Cycle Checkpoint Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Cell Adhesion Mediated By Integrin Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cell Division Multicellular Organismal Metabolic Process Negative Regulation Of Protein Ubiquitination Positive Regulation Of Synapse Maturation Negative Regulation Of Transferase Activity Membrane Protein Ectodomain Proteolysis Regulation Of Synapse Maturation Postreplication Repair Cellular Response To Stress Proteolysis Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Death Cell Differentiation Extracellular Matrix Organization Extracellular Structure Organization Immune System Process Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Mitotic Cell Cycle Checkpoint Mitotic Spindle Assembly Checkpoint Membrane Protein Proteolysis Tissue Development Negative Regulation Of Catalytic Activity Spindle Assembly Checkpoint Positive Regulation Of Protein Metabolic Process Innate Immune Response	Peptidyl-tyrosine Autophosphorylation Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway T Cell Costimulation Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Vesicle-mediated Transport Axon Guidance Phagocytosis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Metabolic Process Membrane Tubulation Regulation Of Endocytosis Regulation Of Cell Adhesion Cellular Response To Peptide Hormone Stimulus Cellular Response To Organonitrogen Compound Immune Response-regulating Signaling Pathway Cellular Response To Peptide Positive Regulation Of Cellular Protein Metabolic Process Protein Autophosphorylation Positive Regulation Of T Cell Activation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Neurotrophin Signaling Pathway Leukocyte Migration Axonogenesis Positive Regulation Of Cell Adhesion Regulation Of Vesicle-mediated Transport Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Locomotion Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Cell-cell Adhesion Axon Development Cellular Response To Hormone Stimulus Regulation Of Phosphorylation Cell Morphogenesis Involved In Neuron Differentiation Actin Cytoskeleton Organization Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		arrested cdk1 configuration eliminated fertility flexible g2 g9a glp h3k27me3 h3k9me2 infertile involves mad2b methyltransferases normally pgc pgcs primordial repressive reprogramming rev7 specification specified stably suppressive switch upregulate waves	adams alkaline alp apparently appeared catenin compartment cytoplasm deposition disintegrin effectors homeostasis immunoreactivity jun lesser metalloprotease mineralization nodule osteoblast osteoblasts osteoclasts phosphatase prominently skeletal taking thickness trabecular unaffected undergo
Tagcloud (Difference) ?		arrested cdk1 configuration eliminated fertility flexible g2 g9a glp h3k27me3 h3k9me2 infertile involves mad2b methyltransferases normally pgc pgcs primordial repressive reprogramming rev7 specification specified stably suppressive switch upregulate waves	adams alkaline alp apparently appeared catenin compartment cytoplasm deposition disintegrin effectors homeostasis immunoreactivity jun lesser metalloprotease mineralization nodule osteoblast osteoblasts osteoclasts phosphatase prominently skeletal taking thickness trabecular unaffected undergo
Tagcloud (Intersection) ?