MAD2L2 and ZNF511

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MAD2L2	ZNF511
Description		mitotic arrest deficient 2 like 2	zinc finger protein 511
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Anaphase-promoting Complex Chromosome Cytoplasm Spindle Cytoskeleton Zeta DNA Polymerase Complex Site Of Double-strand Break	Nucleus
	Molecular Function	Transcription Corepressor Activity Protein Binding JUN Kinase Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Somatic Diversification Of Immunoglobulins Involved In Immune Response DNA Repair Double-strand Break Repair DNA Damage Response Actin Filament Organization Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transcription By Competitive Promoter Binding Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Protein Catabolic Process Error-prone Translesion Synthesis DNA Damage Response, Signal Transduction Resulting In Transcription Telomere Maintenance In Response To DNA Damage Positive Regulation Of Isotype Switching Positive Regulation Of DNA-templated Transcription Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Regulation Of DNA-templated Transcription
Pathways		Translesion synthesis by REV1 Translesion synthesis by POLK Translesion synthesis by POLI
Drugs
Diseases
GWAS		Arterial stiffness (brachial-femoral pulse wave velocity) ( 32790701) Visceral adipose tissue adjusted for BMI ( 22589738)	Nonunion in individuals with fractures ( 30680360)
Interacting Genes		47 interacting genes: ADAM15 ADAM17 ADAM9 CAMK2B CDC20 CDH1 CIMIP1 DEPDC5 ELK1 FAM217B FTO FZR1 GSC2 IKZF1 IKZF3 INCA1 KCTD9 KRT34 MAD2L1 MAD2L1BP MBD3L1 MYBPC2 PLAGL2 POLDIP2 PPM1B PRCC PRR5L PRRC2A RAB11FIP4 RBBP6 REL REV1 REV3L SFI1 SHLD1 TCF4 THAP6 TRIM27 TRIM54 TRIM7 YPEL3 YY1AP1 ZBED1 ZMYND12 ZNF511 ZNF558 ZNF655	14 interacting genes: BOLA2 BOLA2B CFAP206 CLCNKA ENKD1 HSF2BP ISL1 KAT5 LHX2 LMO1 MAD2L2 NTAQ1 SCNM1 SMARCD1
Entrez ID		10459	118472
HPRD ID		07246	15812
Ensembl ID		ENSG00000116670	ENSG00000198546
Uniprot IDs		Q9UI95	Q8NB15
PDB IDs		3ABD 3ABE 3VU7 4EXT 4GK0 4GK5 5XPT 5XPU 6BC8 6BCD 6BI7 6K07 6K08 6KEA 6KTO 6M7A 6M7B 6NIF 6VE5 6WS0 6WS5 6WW9 6WWA 7L9P
Enriched GO Terms of Interacting Partners?		Mitotic Checkpoint Complex Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Metal Ion Binding Translesion Synthesis Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Protein Binding Positive Regulation Of Cell Cycle Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Cell Cycle DNA Binding DNA Biosynthetic Process Postreplication Repair Error-free Translesion Synthesis Positive Regulation Of Synapse Maturation DNA Synthesis Involved In DNA Repair Anaphase-promoting Complex Binding Ubiquitin-protein Transferase Activator Activity Negative Regulation Of Type I Interferon Production Positive Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Error-prone Translesion Synthesis Regulation Of Mitotic Cell Cycle Ubiquitin Ligase Activator Activity Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle DNA-binding Transcription Factor Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Zinc Ion Binding Regulation Of Mitotic Sister Chromatid Separation Regulation Of Nuclear Division Negative Regulation Of Interferon-beta Production Positive Regulation Of Catabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Process Amyloid Precursor Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Chromosome Separation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Regulation Of Cell Cycle Phase Transition SUMO Transferase Activity Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Sister Chromatid Separation Anaphase-promoting Complex Regulation Of Metabolic Process Sequence-specific DNA Binding	Iron-sulfur Cluster Assembly Complex [2Fe-2S] Cluster Assembly Negative Regulation Of Cell Differentiation Positive Regulation Of Double-strand Break Repair Regulation Of Sister Chromatid Segregation Regulation Of Double-strand Break Repair Positive Regulation Of DNA Repair Regulation Of Chromosome Segregation Negative Regulation Of Double-strand Break Repair Via Homologous Recombination 2 Iron, 2 Sulfur Cluster Binding Iron-sulfur Cluster Assembly Negative Regulation Of Developmental Process Chromatin Binding Regulation Of Lymphocyte Activation Positive Regulation Of Myoblast Differentiation Regulation Of DNA Repair Negative Regulation Of DNA Repair Double-strand Break Repair Negative Regulation Of DNA Recombination DNA Damage Response, Signal Transduction Resulting In Transcription Negative Regulation Of Double-strand Break Repair Establishment Of Mitotic Spindle Localization Histone H2AK5 Acetyltransferase Activity Establishment Of Spindle Orientation Establishment Of Mitotic Spindle Orientation Protein-N-terminal Glutamine Amidohydrolase Activity A Axonemal Microtubule Cell Redox Homeostasis Regulation Of Chromosome Organization Establishment Of Spindle Localization Spindle Localization Chromatin Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of DNA Metabolic Process Intracellular Iron Ion Homeostasis Iron-sulfur Cluster Binding Transcription Coactivator Activity Regulation Of Cell Activation Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Peptide Crotonyltransferase Activity Protein-N-terminal Asparagine Amidohydrolase Activity Regulation Of Myoblast Differentiation Positive Regulation Of DNA Recombination Positive Regulation Of RNA Metabolic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Visceral Motor Neuron Differentiation Positive Regulation Of Macrophage Colony-stimulating Factor Production Positive Regulation Of Granulocyte Colony-stimulating Factor Production
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