MAD2L2 and GSC2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MAD2L2	GSC2
Description		mitotic arrest deficient 2 like 2	goosecoid homeobox 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Anaphase-promoting Complex Chromosome Cytoplasm Spindle Cytoskeleton Zeta DNA Polymerase Complex Site Of Double-strand Break	Chromatin Nucleus
	Molecular Function	Transcription Corepressor Activity Protein Binding JUN Kinase Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Somatic Diversification Of Immunoglobulins Involved In Immune Response DNA Repair Double-strand Break Repair DNA Damage Response Actin Filament Organization Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transcription By Competitive Promoter Binding Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Protein Catabolic Process Error-prone Translesion Synthesis DNA Damage Response, Signal Transduction Resulting In Transcription Telomere Maintenance In Response To DNA Damage Positive Regulation Of Isotype Switching Positive Regulation Of DNA-templated Transcription Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anatomical Structure Morphogenesis
Pathways		Translesion synthesis by REV1 Translesion synthesis by POLK Translesion synthesis by POLI
Drugs
Diseases
GWAS		Arterial stiffness (brachial-femoral pulse wave velocity) ( 32790701) Visceral adipose tissue adjusted for BMI ( 22589738)	Metabolite levels ( 22916037)
Interacting Genes		47 interacting genes: ADAM15 ADAM17 ADAM9 CAMK2B CDC20 CDH1 CIMIP1 DEPDC5 ELK1 FAM217B FTO FZR1 GSC2 IKZF1 IKZF3 INCA1 KCTD9 KRT34 MAD2L1 MAD2L1BP MBD3L1 MYBPC2 PLAGL2 POLDIP2 PPM1B PRCC PRR5L PRRC2A RAB11FIP4 RBBP6 REL REV1 REV3L SFI1 SHLD1 TCF4 THAP6 TRIM27 TRIM54 TRIM7 YPEL3 YY1AP1 ZBED1 ZMYND12 ZNF511 ZNF558 ZNF655	60 interacting genes: ALPP ANXA5 ASPH BEST3 BNIP2 C19orf47 C1D CALM1 CALM2 CALM3 CALR CDKN2D CIAO2A COL8A1 CRCP CSNK2A1 DYRK1B EGLN3 EIF5A ETFDH FAM221B FKBP6 GALNT11 GCM2 GTF2H5 GTSF1L GUCA1A GUCY1A2 HMBOX1 ISX KDM6A KLHL38 KRT34 KRTAP5-9 LCE3E LTO1 MAD2L2 MAPK9 MARF1 MID2 MORF4L1 MRPL53 MRPS23 NME7 PACSIN2 PDE4C PRKAB2 PTER RNF4 SCAF1 SDCBP TIPIN TNPO2 TSR2 UBE2R2 VCX2 XRCC4 YPEL5 ZNF444 ZNF587
Entrez ID		10459	2928
HPRD ID		07246	03506
Ensembl ID		ENSG00000116670	ENSG00000063515
Uniprot IDs		Q9UI95	O15499
PDB IDs		3ABD 3ABE 3VU7 4EXT 4GK0 4GK5 5XPT 5XPU 6BC8 6BCD 6BI7 6K07 6K08 6KEA 6KTO 6M7A 6M7B 6NIF 6VE5 6WS0 6WS5 6WW9 6WWA 7L9P
Enriched GO Terms of Interacting Partners?		Mitotic Checkpoint Complex Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Metal Ion Binding Translesion Synthesis Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Protein Binding Positive Regulation Of Cell Cycle Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Cell Cycle DNA Binding DNA Biosynthetic Process Postreplication Repair Error-free Translesion Synthesis Positive Regulation Of Synapse Maturation DNA Synthesis Involved In DNA Repair Anaphase-promoting Complex Binding Ubiquitin-protein Transferase Activator Activity Negative Regulation Of Type I Interferon Production Positive Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Error-prone Translesion Synthesis Regulation Of Mitotic Cell Cycle Ubiquitin Ligase Activator Activity Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle DNA-binding Transcription Factor Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Zinc Ion Binding Regulation Of Mitotic Sister Chromatid Separation Regulation Of Nuclear Division Negative Regulation Of Interferon-beta Production Positive Regulation Of Catabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Process Amyloid Precursor Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Chromosome Separation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Regulation Of Cell Cycle Phase Transition SUMO Transferase Activity Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Sister Chromatid Separation Anaphase-promoting Complex Regulation Of Metabolic Process Sequence-specific DNA Binding	Regulation Of Cell Communication By Electrical Coupling Detection Of Calcium Ion Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Calcium Channel Complex Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Negative Regulation Of High Voltage-gated Calcium Channel Activity Titin Binding Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity DNA Metabolic Process Response To Metal Ion Protein Phosphatase Activator Activity Calyx Of Held Protein Binding Catalytic Complex Negative Regulation Of Transporter Activity Response To Calcium Ion Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Calcineurin-mediated Signaling Presynaptic Cytosol Myelin Sheath Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cardiac Muscle Contraction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Positive Regulation Of Sequestering Of Calcium Ion Negative Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Calcium Ion Transmembrane Transport Regulation Of Striated Muscle Contraction DNA Damage Response Spindle Microtubule Negative Regulation Of Monoatomic Ion Transport Nucleic Acid Metabolic Process Presynaptic Endocytosis Substantia Nigra Development Sarcoplasmic Reticulum Lumen Calcium Channel Regulator Activity Detection Of Chemical Stimulus Sperm Midpiece Adenylate Cyclase Binding Negative Regulation Of Calcium Ion Transport G2/M Transition Of Mitotic Cell Cycle Long-term Synaptic Potentiation Nucleobase-containing Compound Metabolic Process
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