FCHO1 and EXOSC5

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		FCHO1	EXOSC5
Gene Name		FCH domain only 1	exosome component 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Coated Pit Clathrin-coated Vesicle	Exosome (RNase Complex) Nucleus Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin
	Molecular Function	Protein Binding AP-2 Adaptor Complex Binding	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding
	Biological Process	Clathrin Coat Assembly Clathrin-mediated Endocytosis	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Processing Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay DNA Deamination Defense Response To Virus RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways			Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: ACVR1 APP EXOSC5 LGALS14 PTK6 SMURF1 ZBTB16	32 interactors: BIRC2 CALCOCO2 CDK5RAP1 DHRS2 DIS3 DOCK8 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FCHO1 GOLGA2 IKZF3 KIAA1217 KRT13 LIPG LSM5 MPP6 NUP210 PA2G4 PKM POLR2L REL SFPQ SKIV2L2 TNFAIP1 TRIM54 ZNF558
Entrez ID		23149	56915
HPRD ID		16887	16222
Ensembl ID		ENSG00000130475	ENSG00000077348
Uniprot IDs		B7ZAZ3 O14526	M0R050 Q9NQT4
PDB IDs			2NN6
Enriched GO Terms of Interacting Partners?		Regulation Of Ossification Regulation Of Protein Tyrosine Kinase Activity BMP Signaling Pathway Endocardial Cushion Cell Fate Commitment Defense Response Positive Regulation Of Ossification Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell Differentiation Synaptic Growth At Neuromuscular Junction Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Protein Modification Process Tissue Development Collateral Sprouting In Absence Of Injury Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter Tyrosine Phosphorylation Of Stat5 Protein Sexual Reproduction Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of NK T Cell Differentiation Positive Regulation Of Cell Differentiation Regulation Of Peptidyl-tyrosine Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Mitral Valve Morphogenesis Tyrosine Phosphorylation Of Stat3 Protein Male Germ-line Stem Cell Asymmetric Division Cardiac Muscle Cell Fate Commitment Immune System Process Mitral Valve Development Axon Choice Point Recognition Ubiquitin-dependent SMAD Protein Catabolic Process Apoptotic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Germ Cell Development Programmed Cell Death Positive Regulation Of Determination Of Dorsal Identity DNA Deamination Reproduction Cell Death Death Neuron Remodeling Negative Regulation Of Activin Receptor Signaling Pathway Tyrosine Phosphorylation Of STAT Protein Regulation Of Protein Phosphorylation Atrial Septum Primum Morphogenesis Endocardial Cell Differentiation Cellular Protein Metabolic Process	Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RRNA Processing RRNA Metabolic Process Ribosome Biogenesis Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay NcRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process Ribonucleoprotein Complex Biogenesis MRNA Catabolic Process RNA Catabolic Process MRNA Metabolic Process RRNA Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic RNA Metabolic Process Maturation Of 5.8S RRNA Nuclear MRNA Surveillance Aromatic Compound Catabolic Process RNA Surveillance Cellular Macromolecule Catabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression RNA Phosphodiester Bond Hydrolysis Cellular Nitrogen Compound Metabolic Process Catabolic Process Nitrogen Compound Metabolic Process Intracellular MRNA Localization Nuclear Polyadenylation-dependent TRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing Nucleic Acid Phosphodiester Bond Hydrolysis TRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' RNA Processing Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) SnoRNA Metabolic Process RRNA 3'-end Processing Cellular Metabolic Process RNA Localization DNA Deamination Immune System Process Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Immune Response Leukocyte Activation Isotype Switching
Tagcloud ?		abp1 ack1 amphiphysin1 arp3 calm ccs ccss cip4 cme coronin1b decoding dynamin1 endophilin2 engulfed eps15 eps8 epsin2 fbp17 gak hip1r lifeact myosin1e myosin6 necap ocrl1 scission snx9 synaptojanin2beta1 syndapin2
Tagcloud (Difference) ?		abp1 ack1 amphiphysin1 arp3 calm ccs ccss cip4 cme coronin1b decoding dynamin1 endophilin2 engulfed eps15 eps8 epsin2 fbp17 gak hip1r lifeact myosin1e myosin6 necap ocrl1 scission snx9 synaptojanin2beta1 syndapin2
Tagcloud (Intersection) ?