POLE4 and HSPA13

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid, two hybrid)

		POLE4	HSPA13
Description		DNA polymerase epsilon 4, accessory subunit	heat shock protein family A (Hsp70) member 13
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Epsilon DNA Polymerase Complex ATAC Complex	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Protein Heterodimerization Activity	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Heat Shock Protein Binding Protein Folding Chaperone ATP-dependent Protein Folding Chaperone
	Biological Process	DNA-templated DNA Replication DNA Biosynthetic Process	Protein Folding Protein Refolding
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex	Regulation of HSF1-mediated heat shock response
Drugs		Cladribine	Copper
Diseases
GWAS		Venous thromboembolism ( 33592630)
Interacting Genes		7 interacting genes: HSPA13 NFYB POLE POLE2 POLE3 PRKAR1B UBE3A	43 interacting genes: AHCY APP ARHGAP5 BAG6 CAMLG CAND1 CHMP3 CKAP5 CLU CRYGA CTNNA1 DHX30 DHX35 DNM1 DNM3 FRY GIT1 HSP90B1 HSPH1 KIAA0319L LRBA MVP OGT PCBP1 PLXNB3 POLE4 PPP4R3B PSAP PTGES2 PTK2 RALBP1 RMI1 SGTA SGTB SSR1 ST18 TLN2 UBQLN1 UBQLN2 UBQLN4 UBR4 WDR3 XPOT
Entrez ID		56655	6782
HPRD ID		16238	03061
Ensembl ID		ENSG00000115350	ENSG00000155304
Uniprot IDs		Q9NR33	A0A140VK72 P48723
PDB IDs
Enriched GO Terms of Interacting Partners?		Epsilon DNA Polymerase Complex DNA-directed DNA Polymerase Activity Leading Strand Elongation DNA-templated DNA Replication DNA Biosynthetic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation DNA Replication DNA Synthesis Involved In DNA Repair Sperm Entry Positive Regulation Of Golgi Lumen Acidification Lactosylceramide Biosynthetic Process	Positive Regulation Of Proteolysis Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of ERAD Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of ERAD Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cellular Component Assembly Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Polyubiquitin Modification-dependent Protein Binding ERAD Pathway TRC Complex Positive Regulation Of Catabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Proteasomal Protein Catabolic Process Protein Targeting Positive Regulation Of Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Membrane Low-density Lipoprotein Particle Receptor Binding Chromaffin Granule Localization Within Membrane Perinuclear Region Of Cytoplasm Regulation Of Cellular Response To Stress Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Regulation Of Protein Metabolic Process Cellular Localization Protein Insertion Into ER Membrane Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Protein Targeting To ER Identical Protein Binding Cytosol Establishment Of Protein Localization To Endoplasmic Reticulum Protein Phosphatase Binding Autophagy Cytoplasm Positive Regulation Of Protein Metabolic Process Establishment Of Protein Localization To Membrane Positive Regulation Of Microtubule Nucleation Cytoskeleton Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Manganese Ion Establishment Of Protein Localization Negative Regulation Of Protein Catabolic Process
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