POLE4 and POLE2

Number of citations of the paper that reports this interaction (PubMedID 10801849)
0

Data Source:
HPRD (in vitro)

		POLE4	POLE2
Description		DNA polymerase epsilon 4, accessory subunit	DNA polymerase epsilon 2, accessory subunit
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Epsilon DNA Polymerase Complex ATAC Complex	Nucleus Nucleoplasm Chromosome Epsilon DNA Polymerase Complex Nuclear Body Nuclear Lumen
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Protein Heterodimerization Activity	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding
	Biological Process	DNA-templated DNA Replication DNA Biosynthetic Process	DNA Metabolic Process DNA Replication DNA-templated DNA Replication DNA Repair Error-prone Translesion Synthesis
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex	Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex
Drugs		Cladribine	Cladribine
Diseases
GWAS		Venous thromboembolism ( 33592630)	Trigger finger ( 32740585)
Interacting Genes		7 interacting genes: HSPA13 NFYB POLE POLE2 POLE3 PRKAR1B UBE3A	19 interacting genes: AGFG1 BAIAP2L2 EEF1A1 ERG28 EXOSC4 KAT5 MAPRE1 PKM POLE4 REL SAP18 SORBS3 TBX15 TLE1 TRIM27 UBC UBQLN2 ZBED1 ZNF620
Entrez ID		56655	5427
HPRD ID		16238	16007
Ensembl ID		ENSG00000115350	ENSG00000100479
Uniprot IDs		Q9NR33	P56282
PDB IDs			2V6Z 5VBN 7PFO 7PLO
Enriched GO Terms of Interacting Partners?		Epsilon DNA Polymerase Complex DNA-directed DNA Polymerase Activity Leading Strand Elongation DNA-templated DNA Replication DNA Biosynthetic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation DNA Replication DNA Synthesis Involved In DNA Repair Sperm Entry Positive Regulation Of Golgi Lumen Acidification Lactosylceramide Biosynthetic Process	Nucleus Regulation Of Macromolecule Metabolic Process Synaptic Transmission, Dopaminergic Positive Regulation Of Organelle Organization Regulation Of Autophagy Cytosol Transcription Coactivator Activity Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Regulation Of DNA-templated Transcription Auditory Receptor Cell Fate Determination Regulation Of Macromolecule Biosynthetic Process Auditory Receptor Cell Fate Specification Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of Cellular Component Organization Regulation Of Organelle Organization RNA Binding Ficolin-1-rich Granule Lumen Secretory Granule Lumen Identical Protein Binding SUMO Transferase Activity PML Body Protein Autosumoylation Histone H2AK5 Acetyltransferase Activity Mitotic Spindle Pole Establishment Of Mitotic Spindle Orientation Attachment Of Mitotic Spindle Microtubules To Kinetochore Attachment Of Spindle Microtubules To Kinetochore Glyoxal Catabolic Process L-dopa Decarboxylase Activator Activity Guanine Deglycation Protein Deglycase Activity Glyoxalase (glycolic Acid-forming) Activity Glycolate Biosynthetic Process Guanine Deglycation, Methylglyoxal Removal Guanine Deglycation, Glyoxal Removal Detoxification Of Mercury Ion Negative Regulation Of Death-inducing Signaling Complex Assembly Cellular Response To Glyoxal Glyoxal Metabolic Process Positive Regulation Of L-dopa Biosynthetic Process Tyrosine 3-monooxygenase Activator Activity Protein Localization To Astral Microtubule Keratinocyte Apoptotic Process Regulation Of RNA Metabolic Process Establishment Of Mitotic Spindle Localization
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