POLE4 and UBE3A

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		POLE4	UBE3A
Gene Name		polymerase (DNA-directed), epsilon 4, accessory subunit	ubiquitin protein ligase E3A
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Ada2/Gcn5/Ada3 Transcription Activator Complex Epsilon DNA Polymerase Complex	Proteasome Complex Nucleus Cytoplasm Cytosol
	Molecular Function	DNA-directed DNA Polymerase Activity Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity
	Biological Process	Histone H3 Acetylation DNA Biosynthetic Process	Ovarian Follicle Development Proteolysis Ubiquitin-dependent Protein Catabolic Process Brain Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Androgen Receptor Signaling Pathway Sperm Entry Regulation Of Circadian Rhythm Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Autoubiquitination Prostate Gland Growth Protein K48-linked Ubiquitination Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Cardiac hypertrophy ( 21348951) Obesity-related traits ( 23251661)
Protein-Protein Interactions		6 interactors: HSPA13 NFYB POLE POLE2 POLE3 UBE3A	80 interactors: ADRM1 AFG3L1P AFTPH AHSP ANXA1 APP AR ARC ASAP3 ATG9A BARD1 BLK BPY2 BPY2B BPY2C BRCA1 C11orf49 CDKN1B CEBPZ DLG1 EAPP EID1 EIF4G1 HBA1 HPCAL4 HSPA4 JADE1 KLHL38 LCK MAGEA8 MCM7 MDM2 MEOX2 NDUFA13 NELFCD NOMO2 PARVA PDE1B PGR PML POLE4 PRDX1 PSAP PSMC3 PSMD4 RAD23A RAD23B RARA RMI1 RNF2 SACS SCAMP1 SCRIB SGK223 SHBG SMAD9 SOD1 SUMO3 TAT TBC1D14 TCF19 TP53 TRIM65 TSC2 TTC3 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G1 UBE2G2 UBE2L3 UBE2L6 UBQLN2 UCHL5 YOD1 YWHAE YWHAZ
Entrez ID		56655	7337
HPRD ID		16238	03375
Ensembl ID			ENSG00000114062
Uniprot IDs		Q9NR33	Q05086 Q9BUI6 Q9H2G0
PDB IDs			1C4Z 1D5F 1EQX 2KR1 4GIZ
Enriched GO Terms of Interacting Partners?		DNA Biosynthetic Process Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Replication Telomere Maintenance Via Telomere Lengthening DNA Replication Initiation Transcription-coupled Nucleotide-excision Repair Telomere Maintenance Nucleotide-excision Repair DNA-dependent DNA Replication Sperm Entry G1/S Transition Of Mitotic Cell Cycle Chromosome Organization Error-prone Translesion Synthesis DNA Metabolic Process DNA Recombination Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Base-excision Repair, Gap-filling Translesion Synthesis Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process DNA Synthesis Involved In DNA Repair Prostate Gland Growth Postreplication Repair Nucleobase-containing Compound Metabolic Process DNA Repair Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Mitotic Cell Cycle Process Protein K48-linked Ubiquitination Cellular Homeostasis Cellular Nitrogen Compound Metabolic Process Androgen Receptor Signaling Pathway Protein Autoubiquitination Mitotic Cell Cycle Histone H3 Acetylation Cellular Response To DNA Damage Stimulus Nitrogen Compound Metabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Base-excision Repair Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cellular Metabolic Process Ovarian Follicle Development Prostate Gland Development Intracellular Steroid Hormone Receptor Signaling Pathway	Protein Polyubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Protein Catabolic Process Response To Stress Cellular Response To Organic Substance Regulation Of Mitotic Cell Cycle Phase Transition Protein Modification By Small Protein Conjugation Negative Regulation Of Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Response To Organic Substance Cellular Macromolecule Catabolic Process Positive Regulation Of Cellular Metabolic Process Protein Ubiquitination Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Protein Catabolic Process Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic Cell Cycle Checkpoint Cell Death Death Cell Cycle Checkpoint DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Apoptotic Process Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of G1/S Transition Of Mitotic Cell Cycle Signal Transduction Involved In DNA Damage Checkpoint Regulation Of Cell Cycle G1/S Phase Transition Signal Transduction In Response To DNA Damage Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Cell Cycle Arrest Programmed Cell Death Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Catalytic Activity Proteasomal Protein Catabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein K48-linked Ubiquitination Regulation Of Cell Cycle Catabolic Process Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint
Tagcloud ?		acetylase acetylating ada ada2 ada3 atac chrac17 coregulators fam48a gcn5 hereafter invertebrates machineries map3 map3k7 mbip nc2beta p38ip paralogous pole3 saga spt spt20 spt3 staf36 staga taf9 wdr5 yeats2	2h5 accompanies anova dynactin gadd45a gtf2h5 invites keuls macaques malfunctioning nbn1 ndd ndds newman ovx perimenopausal presenilin1 proteosome psen1 rad23a raphe scna serotonin speculation subserving symptomology ube2d3 ubea5 ubiquinase
Tagcloud (Difference) ?		acetylase acetylating ada ada2 ada3 atac chrac17 coregulators fam48a gcn5 hereafter invertebrates machineries map3 map3k7 mbip nc2beta p38ip paralogous pole3 saga spt spt20 spt3 staf36 staga taf9 wdr5 yeats2	2h5 accompanies anova dynactin gadd45a gtf2h5 invites keuls macaques malfunctioning nbn1 ndd ndds newman ovx perimenopausal presenilin1 proteosome psen1 rad23a raphe scna serotonin speculation subserving symptomology ube2d3 ubea5 ubiquinase
Tagcloud (Intersection) ?