APH1B and VSTM1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		APH1B	VSTM1
Description		aph-1B gamma-secretase subunit	V-set and transmembrane domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Endosome Membrane Membrane Transport Vesicle Gamma-secretase Complex	Extracellular Region Extracellular Space Plasma Membrane Membrane
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity Endopeptidase Activator Activity	Cytokine Activity Protein Binding
	Biological Process	Proteolysis Notch Signaling Pathway Notch Receptor Processing Protein Processing Membrane Protein Intracellular Domain Proteolysis Amyloid-beta Formation Amyloid Precursor Protein Catabolic Process	Immune System Process Immune Response-regulating Signaling Pathway
Pathways		Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation TGFBR3 PTM regulation
Drugs
Diseases
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Estimated glomerular filtration rate ( 31152163) Family history of Alzheimer's disease ( 30617256) Metabolite levels ( 23823483) Myopia ( 27182965) Refractive error ( 32231278) Response to fenofibrate (triglyceride levels) ( 27002377) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Small cell lung carcinoma ( 28604730)
Interacting Genes		7 interacting genes: FXYD6-FXYD2 NCSTN PSEN1 PSEN2 TM4SF4 TRARG1 VSTM1	29 interacting genes: ADGRG3 APH1B AQP6 ARL13B CD53 CLDN7 CLDN9 CLEC10A COQ9 ERGIC3 FAM209A FATE1 FBXO2 FCGR1A FNDC9 GJB5 GOLM1 GPX8 HCST KCNJ6 LAMP1 LMNA LRRC4C MANSC1 MRM1 PLPP2 SLC60A2 STMN4 TMEM248
Entrez ID		83464	284415
HPRD ID		06361	15615
Ensembl ID		ENSG00000138613	ENSG00000189068
Uniprot IDs		Q8WW43	D2DJS5 D2DJS6 Q6UX27
PDB IDs		8OQY 8OQZ
Enriched GO Terms of Interacting Partners?		Gamma-secretase Complex Aspartic Endopeptidase Activity, Intramembrane Cleaving Notch Receptor Processing Amyloid-beta Formation Amyloid Precursor Protein Catabolic Process Membrane Protein Ectodomain Proteolysis Amyloid-beta Metabolic Process Amyloid Precursor Protein Metabolic Process Membrane Protein Proteolysis Growth Factor Receptor Binding Synaptic Membrane Notch Signaling Pathway Presynaptic Membrane Synaptic Vesicle Protein Processing Cerebellum Development Azurophil Granule Membrane Protein Maturation Early Endosome Negative Regulation Of Core Promoter Binding Amyloid Precursor Protein Biosynthetic Process ATPase Binding Endopeptidase Activity Myelination Axon Ensheathment Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Peptidase Activity Cajal-Retzius Cell Differentiation Neuron Apoptotic Process Sarcolemma Protein Catabolic Process At Postsynapse Negative Regulation Of Transcription Regulatory Region DNA Binding Short-term Synaptic Potentiation Negative Regulation Of Transcription By RNA Polymerase III Positive Regulation Of L-glutamate Import Across Plasma Membrane Synaptic Vesicle Targeting Astrocyte Activation Involved In Immune Response Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Sequestering Of Calcium Ion Positive Regulation Of Amyloid Fibril Formation Kinetochore Golgi Membrane Regulation Of Calcium Import Into The Mitochondrion Cytoplasmic Vesicle Membrane Glucose Import In Response To Insulin Stimulus Epithelial Cell Proliferation Schwann Cell Differentiation Mitochondrion-endoplasmic Reticulum Membrane Tethering Regulation Of Synaptic Plasticity Regulation Of L-glutamate Import Across Plasma Membrane	Membrane
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