APH1B and TRARG1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		APH1B	TRARG1
Description		aph-1B gamma-secretase subunit	trafficking regulator of GLUT4 (SLC2A4) 1 (gene/pseudogene)
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Endosome Membrane Membrane Transport Vesicle Gamma-secretase Complex	Cytoplasm Plasma Membrane Endomembrane System Membrane Cytoplasmic Vesicle Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity Endopeptidase Activator Activity
	Biological Process	Proteolysis Notch Signaling Pathway Notch Receptor Processing Protein Processing Membrane Protein Intracellular Domain Proteolysis Amyloid-beta Formation Amyloid Precursor Protein Catabolic Process	Cellular Response To Insulin Stimulus Glucose Import In Response To Insulin Stimulus Establishment Of Localization In Cell Protein Localization To Plasma Membrane Vesicle Fusion To Plasma Membrane Endosome To Plasma Membrane Protein Transport
Pathways		Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation TGFBR3 PTM regulation
Drugs
Diseases
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Estimated glomerular filtration rate ( 31152163) Family history of Alzheimer's disease ( 30617256) Metabolite levels ( 23823483) Myopia ( 27182965) Refractive error ( 32231278) Response to fenofibrate (triglyceride levels) ( 27002377) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		7 interacting genes: FXYD6-FXYD2 NCSTN PSEN1 PSEN2 TM4SF4 TRARG1 VSTM1	102 interacting genes: APH1A APH1B AQP12B AQP2 ARL13B BCL2L13 BIK BSCL2 C6orf89 CARINH CCR4 CD300E CD53 CD79A CLDN12 CLDN7 CLDN8 CLEC10A CXCR1 CXCR2 DAGLA EBP EFNA4 ELOVL4 ERGIC3 FAM209A FNDC9 FUT3 GJB3 GPR151 GPR42 GPR61 GPRC5D HSF2BP IFNGR2 IL3RA KASH5 KCNC1 KRT34 KRTAP5-9 LAPTM4B LHFPL5 LY6E MEOX2 MFF MRM1 MRPS18B MTIF3 NPFFR2 NPY2R ODF4 OPN1LW OPRM1 OR7D4 OSTC PDZK1IP1 PLEKHB2 PSCA RHBDL1 RHCG RTP4 SCN3B SDCBP SLC10A1 SLC10A6 SLC13A4 SLC14A2 SLC16A2 SLC1A5 SLC30A2 SLC34A2 SLC35F1 SLC36A1 SLC38A1 SLC38A11 SLC38A6 SLC39A1 SLC71A2 SLC7A1 SLC7A14 SLCO3A1 SPAG4 SSMEM1 SYNPR TAAR9 TM4SF18 TMC4 TMEM179B TMEM237 TMEM248 TMEM31 TMEM45A TMEM52B TMEM69 TMEM71 TMEM80 TMEM9 TMPPE TTYH2 WFS1 YIPF6 ZDHHC4
Entrez ID		83464	286753
HPRD ID		06361	18248
Ensembl ID		ENSG00000138613	ENSG00000184811
Uniprot IDs		Q8WW43	Q8IXB3
PDB IDs		8OQY 8OQZ
Enriched GO Terms of Interacting Partners?		Gamma-secretase Complex Aspartic Endopeptidase Activity, Intramembrane Cleaving Notch Receptor Processing Amyloid-beta Formation Amyloid Precursor Protein Catabolic Process Membrane Protein Ectodomain Proteolysis Amyloid-beta Metabolic Process Amyloid Precursor Protein Metabolic Process Membrane Protein Proteolysis Growth Factor Receptor Binding Synaptic Membrane Notch Signaling Pathway Presynaptic Membrane Synaptic Vesicle Protein Processing Cerebellum Development Azurophil Granule Membrane Protein Maturation Early Endosome Negative Regulation Of Core Promoter Binding Amyloid Precursor Protein Biosynthetic Process ATPase Binding Endopeptidase Activity Myelination Axon Ensheathment Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Peptidase Activity Cajal-Retzius Cell Differentiation Neuron Apoptotic Process Sarcolemma Protein Catabolic Process At Postsynapse Negative Regulation Of Transcription Regulatory Region DNA Binding Short-term Synaptic Potentiation Negative Regulation Of Transcription By RNA Polymerase III Positive Regulation Of L-glutamate Import Across Plasma Membrane Synaptic Vesicle Targeting Astrocyte Activation Involved In Immune Response Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Sequestering Of Calcium Ion Positive Regulation Of Amyloid Fibril Formation Kinetochore Golgi Membrane Regulation Of Calcium Import Into The Mitochondrion Cytoplasmic Vesicle Membrane Glucose Import In Response To Insulin Stimulus Epithelial Cell Proliferation Schwann Cell Differentiation Mitochondrion-endoplasmic Reticulum Membrane Tethering Regulation Of Synaptic Plasticity Regulation Of L-glutamate Import Across Plasma Membrane	Membrane Plasma Membrane Transmembrane Transport Amino Acid Transmembrane Transport Protein Binding Amino Acid Transmembrane Transporter Activity Amino Acid Transport Carboxylic Acid Transport Organic Acid Transport L-amino Acid Transport G Protein-coupled Receptor Activity Carboxylic Acid Transmembrane Transport Organic Acid Transmembrane Transport Organic Anion Transport L-alpha-amino Acid Transmembrane Transport Symporter Activity Amino Acid Import Across Plasma Membrane L-glutamine Transmembrane Transporter Activity Glutamine Transport Interleukin-8-mediated Signaling Pathway Interleukin-8 Receptor Activity Apical Plasma Membrane Monoatomic Ion Transport Basolateral Plasma Membrane Interleukin-8 Binding Sodium Ion Transport Transport Across Blood-brain Barrier Neutral L-amino Acid Transmembrane Transporter Activity Neutral Amino Acid Transport Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity L-glutamine Import Across Plasma Membrane Bile Acid:sodium Symporter Activity Transmembrane Transporter Activity Gamma-secretase Complex G Protein-coupled Receptor Signaling Pathway Metal Ion Transport Inorganic Ion Transmembrane Transport C-X-C Chemokine Receptor Activity Notch Receptor Processing
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