RAB3A and CHML

Number of citations: 0 (PubMedID 12535645)
Data Source: HPRD (two hybrid, in vitro)

		RAB3A	CHML
Name		RAB3A, member RAS oncogene family	CHM like Rab escort protein
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Cytoplasm Lysosome Endosome Cytosol Plasma Membrane Synaptic Vesicle Membrane Transport Vesicle Axon Secretory Granule Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Vesicle Cell Projection Terminal Bouton Synapse Perinuclear Region Of Cytoplasm Presynaptic Active Zone Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Clathrin-sculpted Glutamate Transport Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Clathrin-sculpted Monoamine Transport Vesicle Membrane Presynapse Postsynapse Extracellular Vesicle	Nucleus Nucleoplasm Cytoplasm Cytosol Rab-protein Geranylgeranyltransferase Complex
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Protein-macromolecule Adaptor Activity GTP-dependent Protein Binding Myosin V Binding Metal Ion Binding	GDP-dissociation Inhibitor Activity GTPase Activator Activity Small GTPase Binding
	Biological Process	Plasma Membrane Repair Respiratory System Process Exocytosis Mitochondrion Organization Neuromuscular Synaptic Transmission Axonogenesis Post-embryonic Development Protein Transport Synaptic Vesicle Exocytosis Synaptic Vesicle Maturation Calcium-ion Regulated Exocytosis Regulation Of Exocytosis Insulin Secretion Lung Development Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Lysosome Localization Synaptic Vesicle Recycling Constitutive Secretory Pathway Regulated Exocytosis Positive Regulation Of Exocytosis Regulation Of Short-term Neuronal Synaptic Plasticity Synaptic Vesicle Transport Maintenance Of Presynaptic Active Zone Structure Sensory Perception Of Touch Response To Electrical Stimulus Establishment Of Localization In Cell Acrosomal Vesicle Exocytosis Evoked Neurotransmitter Secretion Synaptic Vesicle Clustering Regulation Of Presynaptic Dense Core Granule Exocytosis Positive Regulation Of Regulated Secretory Pathway Regulation Of Plasma Membrane Repair	Intracellular Protein Transport Small GTPase-mediated Signal Transduction Vesicle-mediated Transport Protein Geranylgeranylation
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs GABA synthesis, release, reuptake and degradation Sensory processing of sound by inner hair cells of the cochlea	RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
GWAS		Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189 )	Daytime sleep phenotypes ( 27126917 )
Interacting Genes		32 interacting genes: A2M ADRB2 AP1M2 APP CASK CHM CHML CHRM4 DMXL2 ECSIT EGFR GRSF1 KRTAP10-8 MAST1 MYO5A PSEN1 RAB3IL1 RAB3IP RABAC1 RABGGTB RABIF REP15 RIMS1 RIMS2 RNF32 RPH3A RPH3AL SGSM2 SNCA SYTL4 SYTL5 VRTN	5 interacting genes: RAB1A RAB3A RAB5A RAB6A RABGGTB
Entrez ID		5864	1122
HPRD ID		01535	00341
Ensembl ID		ENSG00000105649	ENSG00000203668
Uniprot IDs		A0A024R7I7 P20336	P26374
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Small GTPase Binding Vesicle-mediated Transport Cellular Localization Establishment Of Localization In Cell Protein Transport Establishment Of Protein Localization Intracellular Transport Intracellular Protein Localization Rab-protein Geranylgeranyltransferase Complex Synaptic Vesicle Priming Regulation Of Exocytosis Protein Geranylgeranylation Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Vesicle-mediated Transport Synapse Intracellular Protein Transport Protein Prenylation Secretion By Cell Neurexin Family Protein Binding Exocytosis Modulation Of Excitatory Postsynaptic Potential Cytoplasmic Vesicle Secretion Regulation Of Regulated Secretory Pathway Synaptic Vesicle Positive Regulation Of Vesicle Fusion Neuronal Dense Core Vesicle Signal Release Positive Regulation Of Exocytosis Astrocyte Activation Involved In Immune Response Rab Geranylgeranyltransferase Activity Regulation Of Neurotransmitter Secretion Modulation Of Chemical Synaptic Transmission Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Neurotransmitter Transport Synaptic Vesicle Exocytosis Regulation Of Vesicle Fusion Spontaneous Neurotransmitter Secretion Positive Regulation Of Inhibitory Postsynaptic Potential Neurotransmitter Secretion Regulation Of Nervous System Process Regulation Of Secretion By Cell Structural Constituent Of Presynaptic Active Zone Modulation Of Inhibitory Postsynaptic Potential Maintenance Of Presynaptic Active Zone Structure Synapse Organization Regulation Of Synaptic Vesicle Exocytosis Presynaptic Membrane Cellular Response To Amyloid-beta	GTPase Activity GTP Binding Vesicle-mediated Transport Myosin V Binding Synaptic Vesicle Recycling Establishment Of Localization In Cell Endomembrane System Establishment Of Organelle Localization Golgi Vesicle Transport Terminal Bouton Regulation Of Synaptic Vesicle Exocytosis Regulation Of Neuronal Synaptic Plasticity Peptide Hormone Secretion Organelle Localization Protein Transport Intracellular Transport Organelle Transport Along Microtubule Peptide Secretion G Protein Activity Regulation Of Presynaptic Dense Core Granule Exocytosis Regulation Of Neurotransmitter Secretion Positive Regulation Of Exocytosis Evoked Neurotransmitter Secretion Peptidyl-cysteine Methylation Establishment Of Protein Localization Hormone Secretion Peptide Transport Secretory Granule Membrane Hormone Transport Melanosome Intracellular Protein Transport Establishment Of Vesicle Localization Sensory Perception Of Touch Vesicle Localization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cellular Localization Regulation Of Regulated Secretory Pathway Synaptic Vesicle Synaptic Vesicle Membrane Amide Transport Hydrolase Activity Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Regulation Of Dense Core Granule Exocytosis Protein Localization To Early Endosome Endosome To Plasma Membrane Transport Vesicle Nucleotide Binding Intracellular Protein Localization Signal Release Clathrin-sculpted Glutamate Transport Vesicle Membrane Cytoplasmic Side Of Early Endosome Membrane