SLC66A2 and ADH5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SLC66A2	ADH5
Description		solute carrier family 66 member 2	alcohol dehydrogenase 5 (class III), chi polypeptide
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Trans-Golgi Network Cytosol Membrane	Cytoplasm Mitochondrion Cytosol Extracellular Exosome
	Molecular Function	Protein Binding	Alcohol Dehydrogenase (NAD+) Activity Fatty Acid Binding Zinc Ion Binding Electron Transfer Activity Oxidoreductase Activity Formaldehyde Dehydrogenase (NAD+) Activity Identical Protein Binding Metal Ion Binding S-(hydroxymethyl)glutathione Dehydrogenase [NAD(P)+] Activity S-nitrosoglutathione Reductase (NADH) Activity S-(hydroxymethyl)glutathione Dehydrogenase (NADP+) Activity S-(hydroxymethyl)glutathione Dehydrogenase (NAD+) Activity
	Biological Process	Retrograde Transport, Endosome To Golgi Phospholipid Translocation	Retinoid Metabolic Process Respiratory System Process Lipid Metabolic Process Fatty Acid Omega-oxidation Response To Lipopolysaccharide Small Molecule Metabolic Process Positive Regulation Of Blood Pressure Formaldehyde Catabolic Process Response To Nitrosative Stress Response To Redox State
Pathways			Ethanol oxidation
Drugs			NADH Lauric acid 12-Hydroxydodecanoic Acid S-Hydroxymethyl Glutathione
Diseases
GWAS			Alcohol consumption ( 28937693) Alcohol consumption in current drinkers ( 28937693) Alcohol dependence ( 23456092) Blood protein levels ( 30072576) HDL cholesterol ( 24097068 25961943) HDL cholesterol levels ( 28334899) Obesity-related traits ( 23251661) Plateletcrit ( 32888494) Regular attendance at a pub or social club ( 29970889)
Interacting Genes		24 interacting genes: ADH5 AQP6 BEST2 CD79A CLCN7 DIABLO FBLN1 FUNDC2 GJA8 GPR152 IL10RA KCNK5 MGLL RHBDD1 SLC10A1 SLC10A6 SLC25A46 SLC35E3 SLC71A2 STX12 TMEM31 TMEM44 TMEM80 ZFYVE27	10 interacting genes: APP ARNT CHD3 CSNK2B ESRRA PRDX1 SLC66A2 SNTA1 USP40 VTN
Entrez ID		80148	128
HPRD ID		11454	00064
Ensembl ID		ENSG00000122490	ENSG00000197894
Uniprot IDs		K7ERV4 Q8N2U9	P11766 Q6IRT1
PDB IDs			1M6H 1M6W 1MA0 1MC5 1MP0 1TEH 2FZE 2FZW 3QJ5 8GV3
Enriched GO Terms of Interacting Partners?		Transmembrane Transport Membrane Bile Acid:sodium Symporter Activity Chloride Transmembrane Transport Chloride Transport Bile Acid And Bile Salt Transport Inorganic Anion Transmembrane Transport S-(hydroxymethyl)glutathione Dehydrogenase (NADP+) Activity Formaldehyde Dehydrogenase (NAD+) Activity S-(hydroxymethyl)glutathione Dehydrogenase (NAD+) Activity Nitrate Transmembrane Transporter Activity Monoatomic Anion Transmembrane Transport Inorganic Anion Transport Channel Activity Monoatomic Anion Transport Monoatomic Ion Transport Interleukin-10 Binding Organic Hydroxy Compound Transport Intracellularly Ligand-gated Monoatomic Ion Channel Activity Nucleotide-sugar Transmembrane Transporter Activity Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport	Regulation Of Proteolysis Positive Regulation Of Glycolytic Process Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of ATP Metabolic Process Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Receptor-mediated Endocytosis Nuclear Receptor Activity Symbiont-containing Vacuole Regulation Of Carbohydrate Catabolic Process Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of ATP Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Non-canonical NF-kappaB Signal Transduction Golgi Lumen Regulation Of Purine Nucleotide Metabolic Process Endosome To Plasma Membrane Transport Vesicle Regulation Of Protein Metabolic Process Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Protein Catabolic Process Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Nuclear Aryl Hydrocarbon Receptor Complex Response To Oxidative Stress Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Smooth Muscle Cell-matrix Adhesion Rough Endoplasmic Reticulum Lumen Alphav-beta3 Integrin-vitronectin Complex Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To Norepinephrine Stimulus Negative Regulation Of Macromolecule Metabolic Process Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling PML Body Syntrophin Complex
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