SLC66A2 and RHBDD1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLC66A2	RHBDD1
Description		solute carrier family 66 member 2	rhomboid domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Trans-Golgi Network Cytosol Membrane	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Mitochondrial Membrane Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Protein Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Retrograde Transport, Endosome To Golgi Phospholipid Translocation	Proteolysis Apoptotic Process Spermatogenesis Positive Regulation Of Protein Processing Cell Differentiation Membrane Protein Intracellular Domain Proteolysis Membrane Protein Proteolysis Cellular Response To Unfolded Protein Cellular Response To UV ERAD Pathway Negative Regulation Of Apoptotic Process Post-translational Protein Modification Positive Regulation Of Protein Catabolic Process Spermatid Differentiation Positive Regulation Of Secretion Positive Regulation Of Protein Metabolic Process Membrane Protein Proteolysis Involved In Retrograde Protein Transport, ER To Cytosol Regulation Of Male Germ Cell Proliferation
Pathways
Drugs
Diseases
GWAS			Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Kawasaki disease ( 33692975) Pulmonary function ( 17903307)
Interacting Genes		24 interacting genes: ADH5 AQP6 BEST2 CD79A CLCN7 DIABLO FBLN1 FUNDC2 GJA8 GPR152 IL10RA KCNK5 MGLL RHBDD1 SLC10A1 SLC10A6 SLC25A46 SLC35E3 SLC71A2 STX12 TMEM31 TMEM44 TMEM80 ZFYVE27	21 interacting genes: CGRRF1 CMTM5 CREB3L1 CTSA DAPK1 FBXO25 GYPC ITCH LPCAT2 LRRK2 MFHAS1 NEDD4 NSDHL PLEKHB2 RNF5 SEC22B SLC66A2 TGFA TMEM42 TMEM86B TMIE
Entrez ID		80148	84236
HPRD ID		11454	13206
Ensembl ID		ENSG00000122490	ENSG00000144468
Uniprot IDs		K7ERV4 Q8N2U9	Q8TEB9
PDB IDs			5EPP
Enriched GO Terms of Interacting Partners?		Transmembrane Transport Membrane Bile Acid:sodium Symporter Activity Chloride Transmembrane Transport Chloride Transport Bile Acid And Bile Salt Transport Inorganic Anion Transmembrane Transport S-(hydroxymethyl)glutathione Dehydrogenase (NADP+) Activity Formaldehyde Dehydrogenase (NAD+) Activity S-(hydroxymethyl)glutathione Dehydrogenase (NAD+) Activity Nitrate Transmembrane Transporter Activity Monoatomic Anion Transmembrane Transport Inorganic Anion Transport Channel Activity Monoatomic Anion Transport Monoatomic Ion Transport Interleukin-10 Binding Organic Hydroxy Compound Transport Intracellularly Ligand-gated Monoatomic Ion Channel Activity Nucleotide-sugar Transmembrane Transporter Activity Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport	Regulation Of Autophagy Negative Regulation Of Autophagy Endoplasmic Reticulum Membrane Regulation Of Autophagosome Assembly Endoplasmic Reticulum Regulation Of Vacuole Organization Regulation Of Protein Catabolic Process Protein K63-linked Ubiquitination Negative Regulation Of Autophagosome Assembly Positive Regulation Of Protein Catabolic Process Phosphatidylcholine Acyl-chain Remodeling Membrane Syntaxin-1 Binding Ubiquitin-protein Transferase Activity Ether Lipid Metabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Catabolic Process DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Neuromuscular Junction Development Formation Of Structure Involved In A Symbiotic Process Negative Regulation Of Catabolic Process Negative Regulation Of Macroautophagy 3-beta-hydroxysteroid Dehydrogenase [NAD(P)+]/C4-decarboxylase Activity 3-beta-hydroxysteroid Dehydrogenase (NAD+)/C4-decarboxylase Activity Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly D-lysine 5,6-aminomutase Activity Channel Inhibitor Activity Regulation Of Macroautophagy Protein Monoubiquitination Lumenal Side Of Lysosomal Membrane ER To Golgi Transport Vesicle Membrane Regulation Of Macrophage Activation Plasmalogen Synthase Activity Organelle Subcompartment Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Beta-catenin Destruction Complex Binding Ether Hydrolase Activity Alkenylglycerophosphocholine Hydrolase Activity
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