KLK6 and PALB2

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		KLK6	PALB2
Description		kallikrein related peptidase 6	partner and localizer of BRCA2
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GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Extracellular Space Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Secretory Granule Nuclear Membrane Intercellular Bridge	Nucleus Nucleoplasm Nuclear Speck Protein-containing Complex DNA Repair Complex
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	DNA Binding Protein Binding
	Biological Process	Proteolysis Central Nervous System Development Response To Wounding Regulation Of Neuron Projection Development Protein Autoprocessing Collagen Catabolic Process Tissue Regeneration Hormone Metabolic Process Myelination Amyloid Precursor Protein Metabolic Process Regulation Of Cell Differentiation Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Protein Maturation	Double-strand Break Repair Via Homologous Recombination In Utero Embryonic Development Somitogenesis Inner Cell Mass Cell Proliferation DNA Repair DNA Recombination Apoptotic Process DNA Damage Response Mesoderm Development Animal Organ Morphogenesis Multicellular Organism Growth Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process Embryonic Organ Development
Pathways			HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Neddylation Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to PALB2 KEAP1-NFE2L2 pathway
Drugs		Benzamidine
Diseases			Fanconi anemia
GWAS		Blood protein levels in cardiovascular risk ( 28369058)	Bipolar disorder ( 17554300)
Interacting Genes		7 interacting genes: LSP1 PALB2 PAX2 SERPINC1 SERPINF2 SNCA TSG101	31 interacting genes: BCAS3 BRCA2 CASZ1 CCL5 CST6 DIRAS3 ERRFI1 GREB1 H2BC3 H3C1 H4C1 HNRNPC IL13RA2 IL24 KLK6 LRATD2 LYPD3 MRC2 NAT2 PDS5B PRDM14 RAD51AP1 RAD51C RHOBTB2 RNF168 SERPINB5 SNAI1 THRSP USP2 USP22 XRCC3
Entrez ID		5653	79728
HPRD ID		04037	07966
Ensembl ID		ENSG00000167755	ENSG00000083093
Uniprot IDs		Q92876	A0A8V8TLC8 A0A8V8TMK8 A0AAQ5BGU0 H3BN63 I3L1Z5 Q86YC2
PDB IDs		1GVL 1L2E 1LO6 3VFE 4D8N 5NX1 5NX3 6QFF 6QFG 6QFH 6QH9 6QHA 6QHB 6QHC 6SKB 6SKC 6SKD 7QFT 7QFV 7QHZ 7QI0	2W18 3EU7 7S4A 8YAP
Enriched GO Terms of Interacting Partners?		Peptidase Inhibitor Activity Regulation Of Hemostasis Protease Binding Regulation Of Blood Coagulation Serine-type Endopeptidase Inhibitor Activity Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Pronephric Field Specification Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Optic Chiasma Development Positive Regulation Of Optic Nerve Formation Regulation Of Metanephros Size Optic Nerve Structural Organization Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Positive Regulation Of Metanephric DCT Cell Differentiation Optic Cup Morphogenesis Involved In Camera-type Eye Development Positive Regulation Of Cellular Component Biogenesis Response To Desipramine Positive Regulation Of Exocytosis Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Regulation Of Norepinephrine Uptake Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Establishment Of Vesicle Localization Positive Regulation Of Ubiquitin-dependent Endocytosis Regulation Of Wound Healing Blood Microparticle Regulation Of Reactive Oxygen Species Metabolic Process Vestibulocochlear Nerve Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Nephron Morphogenesis Metanephric Nephron Tubule Formation Metanephric Distal Convoluted Tubule Development Nephric Duct Formation Positive Regulation Of Metanephric Glomerulus Development Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Ureter Maturation Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Negative Regulation Of Protein Metabolic Process Negative Regulation Of Dopamine Metabolic Process Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Vesicle Localization Regulation Of Serotonin Uptake Exosomal Secretion Positive Regulation Of Viral Budding Via Host ESCRT Complex Optic Nerve Morphogenesis Metanephric Tubule Formation	Chromatin Remodeling Telomere Maintenance Via Recombination Telomere Organization Chromatin Organization Rad51C-XRCC3 Complex Mitotic Recombination Chromosome, Telomeric Region Positive Regulation Of Cell Cycle Nucleoplasm Chromosome Organization Double-strand Break Repair Interstrand Cross-link Repair DNA Recombination Positive Regulation Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination Recombinational Repair Crossover Junction DNA Endonuclease Activity Cornified Envelope Histone H4 Acetyltransferase Activity Protein-DNA Complex Assembly Four-way Junction DNA Binding Structural Constituent Of Chromatin ATP-dependent DNA Damage Sensor Activity DNA Binding Telomere Maintenance Nucleosome Assembly Male Meiosis I
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