KLK6 and SERPINC1

Number of citations of the paper that reports this interaction (PMID 12878203)
15

Data Source:
HPRD (in vitro)

		KLK6	SERPINC1
Gene Name		kallikrein-related peptidase 6	serpin peptidase inhibitor, clade C (antithrombin), member 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Microtubule Cytoskeleton Nuclear Membrane Intercellular Bridge	Extracellular Region Extracellular Space Plasma Membrane Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding	Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Heparin Binding
	Biological Process	Proteolysis Central Nervous System Development Response To Wounding Regulation Of Neuron Projection Development Protein Processing Protein Autoprocessing Collagen Catabolic Process Tissue Regeneration Hormone Metabolic Process Myelination Amyloid Precursor Protein Metabolic Process Regulation Of Cell Differentiation Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Neuron Death	Response To Nutrient Blood Coagulation Negative Regulation Of Endopeptidase Activity Negative Regulation Of Inflammatory Response Regulation Of Blood Coagulation, Intrinsic Pathway
Pathways			Common Pathway Intrinsic Pathway Formation of Fibrin Clot (Clotting Cascade)
Drugs		Benzamidine	Ardeparin Fondaparinux sodium Heparin Enoxaparin Alpha-D-Mannose N-Formylmethionine Sulodexide Dalteparin Tinzaparin Nadroparin
Diseases
GWAS
Protein-Protein Interactions		3 interactors: SERPINC1 SERPINF2 SNCA	5 interactors: F2 KLK2 KLK6 PLG SDC2
Entrez ID		5653	462
HPRD ID		04037	00122
Ensembl ID		ENSG00000167755	ENSG00000117601
Uniprot IDs		Q92876	P01008
PDB IDs		1GVL 1L2E 1LO6 3VFE 4D8N	1ANT 1ATH 1AZX 1BR8 1DZG 1DZH 1E03 1E04 1E05 1JVQ 1LK6 1NQ9 1OYH 1R1L 1SR5 1T1F 1TB6 2ANT 2B4X 2B5T 2BEH 2GD4 2HIJ 2ZNH 3EVJ 3KCG 4EB1
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Regulation Of Proteolysis Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Blood Coagulation Negative Regulation Of Protein Metabolic Process Regulation Of Wound Healing Negative Regulation Of Thrombin Receptor Signaling Pathway Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake Regulation Of Blood Coagulation, Intrinsic Pathway Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Serotonin Uptake Negative Regulation Of Dopamine Metabolic Process Negative Regulation Of Cellular Respiration Negative Regulation Of Oxidative Phosphorylation Negative Regulation Of Synaptic Transmission, Dopaminergic Regulation Of Blood Vessel Size By Renin-angiotensin Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Response To Iron(II) Ion Cellular Response To Copper Ion Extracellular Matrix Organization Negative Regulation Of Cellular Metabolic Process Extracellular Structure Organization Regulation Of Protein Metabolic Process Regulation Of Synaptic Vesicle Recycling Negative Regulation Of Plasminogen Activation Blood Coagulation Hemostasis Regulation Of Catalytic Activity Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Fibrinolysis Regulation Of Oxidative Phosphorylation Positive Regulation Of Inositol Phosphate Biosynthetic Process Regulation Of Hydrogen Peroxide Metabolic Process Dopamine Transport Regulation Of Cytoskeleton Organization Regulation Of Glutamate Secretion Dopamine Biosynthetic Process	Negative Regulation Of Fibrinolysis Wound Healing Regulation Of Fibrinolysis Response To Wounding Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Fibrinolysis Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Wound Healing Tissue Regeneration Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Proteolysis Extracellular Matrix Disassembly Regulation Of Blood Coagulation Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Neurogenesis Regulation Of Wound Healing Regulation Of Cell Development Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Mononuclear Cell Migration Platelet Activation Protein Metabolic Process Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Fibrinolysis Leukocyte Migration Locomotion Developmental Growth Cell Differentiation Response To Stress Protein Autoprocessing Movement Of Cell Or Subcellular Component Regulation Of Neuron Projection Development Generation Of Neurons Regulation Of Cell Differentiation Peptidyl-glutamic Acid Carboxylation Blood Coagulation Neurogenesis Hemostasis Blood Coagulation, Intrinsic Pathway Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Platelet Activation Regulation Of Cell Morphogenesis Catabolic Process Regulation Of Cell Projection Organization Amyloid Precursor Protein Metabolic Process Growth
Tagcloud ?		abundance abundant acrylic capture captured depletion eluate elution facilitated fractionation hydrogel ibp2 igf1 incubated interfere irreversibly isk5 isopropylacrylamide opens orders particles perspectives platforms plf4 proteome protocols srm supernatants trapped	antithrombin autosomal buccal budapest cct clade codon cover deep deficiency exons giving heterozygous inherited malay malaysia malaysian mucosal ncbi peptidase swabs thr thrombin thromboembolism thrombosis vte woman
Tagcloud (Difference) ?		abundance abundant acrylic capture captured depletion eluate elution facilitated fractionation hydrogel ibp2 igf1 incubated interfere irreversibly isk5 isopropylacrylamide opens orders particles perspectives platforms plf4 proteome protocols srm supernatants trapped	antithrombin autosomal buccal budapest cct clade codon cover deep deficiency exons giving heterozygous inherited malay malaysia malaysian mucosal ncbi peptidase swabs thr thrombin thromboembolism thrombosis vte woman
Tagcloud (Intersection) ?