KLK6 and LSP1

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		KLK6	LSP1
Description		kallikrein related peptidase 6	lymphocyte specific protein 1
Image
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Extracellular Space Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Secretory Granule Nuclear Membrane Intercellular Bridge	Plasma Membrane Actin Cytoskeleton Membrane Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Actin Binding Protein Binding
	Biological Process	Proteolysis Central Nervous System Development Response To Wounding Regulation Of Neuron Projection Development Protein Autoprocessing Collagen Catabolic Process Tissue Regeneration Hormone Metabolic Process Myelination Amyloid Precursor Protein Metabolic Process Regulation Of Cell Differentiation Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Protein Maturation	Chemotaxis Defense Response Cellular Defense Response Signal Transduction Cellular Response To Interleukin-7
Pathways
Drugs		Benzamidine
Diseases
GWAS		Blood protein levels in cardiovascular risk ( 28369058)	Bladder cancer ( 24163127) Breast cancer ( 20453838 17529967 23535729 29059683 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Celiac disease ( 23936387) Central corneal thickness ( 32528159) Diastolic blood pressure ( 30487518 27618452 27841878) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Granulocyte percentage of myeloid white cells ( 27863252) Hypertension ( 30487518) Inflammatory bowel disease ( 28067908 23128233) Lymphocyte count ( 32888494) Mammographic density (dense area) ( 25342443) Mean arterial pressure ( 29403010 30487518) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (antihypertensives) ( 31015401) Medication use (beta blocking agents) ( 31015401) Methadone dose in opioid dependence ( 28115739) Milk allergy ( 25710614) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Potassium levels ( 29403010) Pulse pressure ( 30578418 27841878) Pulse pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure ( 27618452 29403010 30487518 30578418 27841878) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Ulcerative colitis ( 28067908 21297633)
Interacting Genes		7 interacting genes: LSP1 PALB2 PAX2 SERPINC1 SERPINF2 SNCA TSG101	11 interacting genes: ACTG1 BMPR2 CFTR GREB1 IL24 KLK6 LYPD3 MAPKAPK2 SCGB2A2 SNAI1 THRSP
Entrez ID		5653	4046
HPRD ID		04037	01083
Ensembl ID		ENSG00000167755	ENSG00000130592
Uniprot IDs		Q92876	A8K7L8 P33241
PDB IDs		1GVL 1L2E 1LO6 3VFE 4D8N 5NX1 5NX3 6QFF 6QFG 6QFH 6QH9 6QHA 6QHB 6QHC 6SKB 6SKC 6SKD 7QFT 7QFV 7QHZ 7QI0	3BH8 4NO0 4NO2
Enriched GO Terms of Interacting Partners?		Peptidase Inhibitor Activity Regulation Of Hemostasis Protease Binding Regulation Of Blood Coagulation Serine-type Endopeptidase Inhibitor Activity Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Pronephric Field Specification Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Optic Chiasma Development Positive Regulation Of Optic Nerve Formation Regulation Of Metanephros Size Optic Nerve Structural Organization Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Positive Regulation Of Metanephric DCT Cell Differentiation Optic Cup Morphogenesis Involved In Camera-type Eye Development Positive Regulation Of Cellular Component Biogenesis Response To Desipramine Positive Regulation Of Exocytosis Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Regulation Of Norepinephrine Uptake Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Establishment Of Vesicle Localization Positive Regulation Of Ubiquitin-dependent Endocytosis Regulation Of Wound Healing Blood Microparticle Regulation Of Reactive Oxygen Species Metabolic Process Vestibulocochlear Nerve Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Nephron Morphogenesis Metanephric Nephron Tubule Formation Metanephric Distal Convoluted Tubule Development Nephric Duct Formation Positive Regulation Of Metanephric Glomerulus Development Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Ureter Maturation Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Negative Regulation Of Protein Metabolic Process Negative Regulation Of Dopamine Metabolic Process Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Vesicle Localization Regulation Of Serotonin Uptake Exosomal Secretion Positive Regulation Of Viral Budding Via Host ESCRT Complex Optic Nerve Morphogenesis Metanephric Tubule Formation
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