KLK6 and SERPINF2

Number of citations of the paper that reports this interaction (PMID 12878203)
15

Data Source:
HPRD (in vitro)

		KLK6	SERPINF2
Gene Name		kallikrein-related peptidase 6	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Microtubule Cytoskeleton Nuclear Membrane Intercellular Bridge	Extracellular Region Fibrinogen Complex Extracellular Space Cell Surface Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Proteolysis Central Nervous System Development Response To Wounding Regulation Of Neuron Projection Development Protein Processing Protein Autoprocessing Collagen Catabolic Process Tissue Regeneration Hormone Metabolic Process Myelination Amyloid Precursor Protein Metabolic Process Regulation Of Cell Differentiation Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Neuron Death	Regulation Of Blood Vessel Size By Renin-angiotensin Platelet Degranulation Acute-phase Response Blood Coagulation Response To Organic Substance Negative Regulation Of Plasminogen Activation Negative Regulation Of Endopeptidase Activity Platelet Activation Collagen Fibril Organization Positive Regulation Of Collagen Biosynthetic Process Fibrinolysis Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Blood Vessel Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Fibrinolysis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways			Response to elevated platelet cytosolic Ca2+ Platelet degranulation Dissolution of Fibrin Clot Platelet activation, signaling and aggregation
Drugs		Benzamidine	Ocriplasmin
Diseases
GWAS			Calcium levels ( 20705733) Serum albumin level ( 23022100)
Protein-Protein Interactions		3 interactors: SERPINC1 SERPINF2 SNCA	17 interactors: BCAP31 CFD CTRB1 DEFA1 ELANE F11 F13A1 FGA KLK13 KLK2 KLK6 PLAU PLG PRSS1 SERPINB12 SSR1 TGM2
Entrez ID		5653	5345
HPRD ID		04037	02029
Ensembl ID		ENSG00000167755	ENSG00000167711
Uniprot IDs		Q92876	P08697
PDB IDs		1GVL 1L2E 1LO6 3VFE 4D8N
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Regulation Of Proteolysis Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Blood Coagulation Negative Regulation Of Protein Metabolic Process Regulation Of Wound Healing Negative Regulation Of Thrombin Receptor Signaling Pathway Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake Regulation Of Blood Coagulation, Intrinsic Pathway Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Serotonin Uptake Negative Regulation Of Dopamine Metabolic Process Negative Regulation Of Cellular Respiration Negative Regulation Of Oxidative Phosphorylation Negative Regulation Of Synaptic Transmission, Dopaminergic Regulation Of Blood Vessel Size By Renin-angiotensin Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Response To Iron(II) Ion Cellular Response To Copper Ion Extracellular Matrix Organization Negative Regulation Of Cellular Metabolic Process Extracellular Structure Organization Regulation Of Protein Metabolic Process Regulation Of Synaptic Vesicle Recycling Negative Regulation Of Plasminogen Activation Blood Coagulation Hemostasis Regulation Of Catalytic Activity Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Fibrinolysis Regulation Of Oxidative Phosphorylation Positive Regulation Of Inositol Phosphate Biosynthetic Process Regulation Of Hydrogen Peroxide Metabolic Process Dopamine Transport Regulation Of Cytoskeleton Organization Regulation Of Glutamate Secretion Dopamine Biosynthetic Process	Extracellular Matrix Disassembly Proteolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Wound Healing Negative Regulation Of Wound Healing Extracellular Matrix Organization Extracellular Structure Organization Platelet Degranulation Response To Wounding Blood Coagulation Hemostasis Protein Metabolic Process Regulation Of Blood Coagulation Regulation Of Wound Healing Regulation Of Body Fluid Levels Positive Regulation Of Fibrinolysis Platelet Activation Positive Regulation Of Mitochondrial Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Response To Stress Vesicle-mediated Transport Regulation Of Fibrinolysis Mitochondrial Calcium Ion Homeostasis Cobalamin Metabolic Process Exocytosis Killing Of Cells Of Other Organism Defense Response To Fungus Fibrinolysis Protein Activation Cascade Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Cell-substrate Adhesion Response To Fungus Secretion By Cell Immune System Process Peptide Cross-linking Protein Processing Tissue Regeneration Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Blood Coagulation, Common Pathway Blood Coagulation, Common Pathway Regulation Of Cell Adhesion Secretion Collagen Catabolic Process Cellular Calcium Ion Homeostasis Cell Activation Calcium Ion Homeostasis Cellular Homeostasis Positive Regulation Of Signal Transduction Collagen Metabolic Process
Tagcloud ?		abundance abundant acrylic capture captured depletion eluate elution facilitated fractionation hydrogel ibp2 igf1 incubated interfere irreversibly isk5 isopropylacrylamide opens orders particles perspectives platforms plf4 proteome protocols srm supernatants trapped
Tagcloud (Difference) ?		abundance abundant acrylic capture captured depletion eluate elution facilitated fractionation hydrogel ibp2 igf1 incubated interfere irreversibly isk5 isopropylacrylamide opens orders particles perspectives platforms plf4 proteome protocols srm supernatants trapped
Tagcloud (Intersection) ?