KLK6 and SERPINF2

Number of citations of the paper that reports this interaction (PubMedID 12878203)
0

Data Source:
HPRD (in vitro)

		KLK6	SERPINF2
Description		kallikrein related peptidase 6	serpin family F member 2
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Extracellular Space Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Secretory Granule Nuclear Membrane Intercellular Bridge	Extracellular Region Fibrinogen Complex Extracellular Space Cell Surface Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity Protein Homodimerization Activity
	Biological Process	Proteolysis Central Nervous System Development Response To Wounding Regulation Of Neuron Projection Development Protein Autoprocessing Collagen Catabolic Process Tissue Regeneration Hormone Metabolic Process Myelination Amyloid Precursor Protein Metabolic Process Regulation Of Cell Differentiation Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Protein Maturation	Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Acute-phase Response Negative Regulation Of Plasminogen Activation Collagen Fibril Organization Positive Regulation Of Collagen Biosynthetic Process Fibrinolysis Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Blood Vessel Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Coagulation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Fibrinolysis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways			Platelet degranulation Dissolution of Fibrin Clot
Drugs		Benzamidine	Ocriplasmin Copper
Diseases			Alpha-2-plasmin inhibitor (a2-PI) deficiency
GWAS		Blood protein levels in cardiovascular risk ( 28369058)	Calcium levels ( 20705733 24068962) Hodgkin's lymphoma ( 34216518) Serum albumin levels ( 23022100 29403010) Severe insulin-deficient type 2 diabetes ( 34737425) Urate levels ( 31578528)
Interacting Genes		7 interacting genes: LSP1 PALB2 PAX2 SERPINC1 SERPINF2 SNCA TSG101	17 interacting genes: BCAP31 CFD CTRB1 DEFA1 ELANE F11 F13A1 FGA KLK13 KLK2 KLK6 PLAU PLG PRSS1 SERPINB12 SSR1 TGM2
Entrez ID		5653	5345
HPRD ID		04037	02029
Ensembl ID		ENSG00000167755	ENSG00000167711
Uniprot IDs		Q92876	P08697
PDB IDs		1GVL 1L2E 1LO6 3VFE 4D8N 5NX1 5NX3 6QFF 6QFG 6QFH 6QH9 6QHA 6QHB 6QHC 6SKB 6SKC 6SKD 7QFT 7QFV 7QHZ 7QI0
Enriched GO Terms of Interacting Partners?		Peptidase Inhibitor Activity Regulation Of Hemostasis Protease Binding Regulation Of Blood Coagulation Serine-type Endopeptidase Inhibitor Activity Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Pronephric Field Specification Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Optic Chiasma Development Positive Regulation Of Optic Nerve Formation Regulation Of Metanephros Size Optic Nerve Structural Organization Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Positive Regulation Of Metanephric DCT Cell Differentiation Optic Cup Morphogenesis Involved In Camera-type Eye Development Positive Regulation Of Cellular Component Biogenesis Response To Desipramine Positive Regulation Of Exocytosis Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Regulation Of Norepinephrine Uptake Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Establishment Of Vesicle Localization Positive Regulation Of Ubiquitin-dependent Endocytosis Regulation Of Wound Healing Blood Microparticle Regulation Of Reactive Oxygen Species Metabolic Process Vestibulocochlear Nerve Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Nephron Morphogenesis Metanephric Nephron Tubule Formation Metanephric Distal Convoluted Tubule Development Nephric Duct Formation Positive Regulation Of Metanephric Glomerulus Development Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Ureter Maturation Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Negative Regulation Of Protein Metabolic Process Negative Regulation Of Dopamine Metabolic Process Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Vesicle Localization Regulation Of Serotonin Uptake Exosomal Secretion Positive Regulation Of Viral Budding Via Host ESCRT Complex Optic Nerve Morphogenesis Metanephric Tubule Formation	Serine-type Peptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Protein Processing Protein Maturation Extracellular Space Proteolysis Extracellular Region Zymogen Activation Blood Coagulation Coagulation Hydrolase Activity Hemostasis Extracellular Matrix Negative Regulation Of Blood Coagulation Plasminogen Activation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Protein Metabolic Process Platelet Alpha Granule Lumen Regulation Of Fibrinolysis Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Fibrinolysis Secretory Granule Positive Regulation Of Fibrinolysis Blood Microparticle Biological Process Involved In Interaction With Symbiont Regulation Of Body Fluid Levels Extracellular Exosome Regulation Of Wound Healing Extracellular Matrix Disassembly Protein-glutamine Gamma-glutamyltransferase Activity Regulation Of Response To Wounding Blood Coagulation, Fibrin Clot Formation Negative Regulation Of Fibrinolysis Endopeptidase Activity Macromolecule Metabolic Process Peptide Cross-linking Protein Activation Cascade Negative Regulation Of Protein Maturation Positive Regulation Of Blood Coagulation Digestion Cell Surface Positive Regulation Of Coagulation Killing By Host Of Symbiont Cells Response To Bacterium Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Serine-type Aminopeptidase Activity
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