PARD3 and SMAD2

Number of citations of the paper that reports this interaction (PubMedID 12650946)
0

Data Source:
HPRD (two hybrid, in vitro)

		PARD3	SMAD2
Description		par-3 family cell polarity regulator	SMAD family member 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Cell Cortex Endomembrane System Membrane Apical Plasma Membrane Cell Junction Internode Region Of Axon Apical Junction Complex Tight Junction Anchoring Junction PAR Polarity Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Activin Responsive Factor Complex Protein-containing Complex SMAD Protein Complex Homomeric SMAD Protein Complex Heteromeric SMAD Protein Complex
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Lipid Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Phosphatase Binding Ubiquitin Protein Ligase Binding Type I Transforming Growth Factor Beta Receptor Binding Identical Protein Binding SMAD Binding Metal Ion Binding Tau Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Co-SMAD Binding I-SMAD Binding R-SMAD Binding Disordered Domain Specific Binding DNA-binding Transcription Factor Binding
	Biological Process	Microtubule Cytoskeleton Organization Protein Targeting To Membrane Cell Adhesion Establishment Or Maintenance Of Cell Polarity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Axonogenesis Intracellular Protein Localization Asymmetric Cell Division Negative Regulation Of Peptidyl-threonine Phosphorylation Myelination In Peripheral Nervous System Establishment Of Cell Polarity Cell Differentiation Positive Regulation Of Myelination Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell Division Establishment Of Centrosome Localization Protein-containing Complex Assembly Bicellular Tight Junction Assembly Establishment Of Epithelial Cell Polarity	Ureteric Bud Development In Utero Embryonic Development Endoderm Formation Mesoderm Formation Regionalization Determination Of Left/right Asymmetry In Lateral Mesoderm Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Morphogenesis DNA-templated Transcription Regulation Of DNA-templated Transcription Transforming Growth Factor Beta Receptor Signaling Pathway Zygotic Specification Of Dorsal/ventral Axis Gastrulation Pattern Specification Process Endoderm Development Mesoderm Development Heart Development Cell Population Proliferation Anatomical Structure Morphogenesis Response To Glucose Post-embryonic Development Embryonic Pattern Specification Anterior/posterior Pattern Specification Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Insulin Secretion Cell Differentiation Negative Regulation Of Ossification Lung Development Positive Regulation Of BMP Signaling Pathway Pancreas Development Primary MiRNA Processing Activin Receptor Signaling Pathway Organ Growth Intracellular Signal Transduction Nodal Signaling Pathway Cell Fate Commitment Negative Regulation Of Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Paraxial Mesoderm Morphogenesis Developmental Growth Embryonic Foregut Morphogenesis Embryonic Cranial Skeleton Morphogenesis Regulation Of Multicellular Organismal Process Pericardium Development SMAD Protein Signal Transduction Mesenchyme Development Trophoblast Cell Migration Secondary Palate Development Response To Cholesterol Response To Transforming Growth Factor Beta Odontoblast Differentiation
Pathways		TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tight junction interactions	Signaling by NODAL Signaling by NODAL Signaling by Activin Signaling by Activin Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/3 Phosphorylation Motif Mutants in Cancer SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Transcriptional regulation of pluripotent stem cells Ub-specific processing proteases FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes Germ layer formation at gastrulation Formation of axial mesoderm Formation of definitive endoderm Formation of definitive endoderm
Drugs			Dexfosfoserine
Diseases			Colorectal cancer
GWAS		Acute lymphoblastic leukemia (childhood) ( 19684603) Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Corneal astigmatism ( 30306274) Emphysema-related traits ( 20709820) Estimated glomerular filtration rate ( 31015462) Gut microbiota relative abundance (Sutterella) ( 33208821) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 28552196) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung function (FEV1/FVC) ( 30804560) Major depressive disorder ( 21621269) Parkinson's disease progression (composite) ( 33111402) Schizophrenia ( 21682944)	Coronary artery disease in type 1 diabetes ( 29695241) Daytime nap ( 33568662) Lung cancer in ever smokers ( 28604730) Menarche (age at onset) ( 27182965)
Interacting Genes		31 interacting genes: ACE2 CDC42 DYNLL1 F11R INSC LIMK2 NECTIN1 NECTIN3 PARD6A PARD6B PARD6G PATJ PLCB1 PLCB3 PNMA1 PRKCG PRKCI SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 STK11 TIAM1 TIAM2 TTN UBC YWHAB YWHAG YWHAH YWHAZ	220 interacting genes: ABTB1 ACVR1B AFDN AKT1 ANAPC10 ANAPC2 ANK3 ANP32B ANP32E ANTXR2 AP1B1 ARFGAP3 ARHGEF6 ARL4D ATP5ME AXIN1 BAZ1A BECN1 BPTF BRCA1 BTBD2 C22orf46P CAMK2A CAMK2G CDC16 CDC27 CDC40 CDK2 CDK4 CDK8 CDK9 CISH COPS5 CORO2A CREBBP CSH1 CSH2 CSNK1D CTNNB1 CUL5 CYLC2 CYP11A1 DAB2 DCAF6 DCUN1D1 DENND2B DNAJB5 DNAJC7 DOCK8 DVL1 DYNC1H1 DYRK1A E2F4 EEF1A1 EID2 EIF3L ELAC2 EP300 ERBIN ESR1 ESR2 FAM161B FBN2 FBP2 FHL2 FHL3 FOXG1 FOXH1 FOXO3 GATAD2B GFER GLI3 GRIPAP1 GSC GTF2I HDAC1 HDAC2 HGS HIPK2 HNF4A HOXA13 HOXA9 HOXD13 HSD17B3 HUWE1 HYAL2 INSR IRAK2 ITCH JUN KAT2B KHDRBS1 KPNB1 LAMA5 LATS2 LCK LEF1 LEMD3 LHX9 LITAF LMO2 MAP2K1 MAPK1 MAPK3 MAPK8 MAPK9 MECOM MED15 MED6 MEF2A MEF2C MYC MYOCD NAGK NCOA6 NEDD4L NEDD9 NEFM NFIA NFYC NOTCH4 NUAK2 NUP153 NUP214 OS9 OTUB1 PAK1 PAPOLA PAPPA PARD3 PAXIP1 PEX19 PIAS3 PIAS4 PIK3CA PLIN3 POU2AF1 PPM1A PPP2R1A PRKAR1A PSAP PSG9 PSMD11 PSMD8 PTMS RAB34 RAB38 RAN RANBP6 RANBP9 RARB RASA1 RASD2 RASL12 RBL1 RHEBL1 RHOA RHOD RHOJ RIT1 RNF123 RNPC3 ROCK1 RPS14 RPS27A RUNX2 RXRA SKI SKIL SKOR2 SMAD1 SMAD3 SMAD4 SMAD7 SMAD9 SMURF1 SMURF2 SNAPIN SNIP1 SNRNP70 SNW1 SOD1 SP1 SQSTM1 SRI ST13 STAG1 STAMBP STAMBPL1 STRAP STUB1 SYT1 TBC1D1 TGFBR1 TGFBRAP1 TGIF1 TGM2 TNNT1 TOB1 TP53 TP73 TRIM62 TRMO TSC2 TUBA1B UBA52 UBR5 UCHL5 USP9X WASHC4 XPA YY1 ZEB1 ZEB2 ZFYVE9 ZMYND11 ZNF41 ZNF510 ZNF8 ZNHIT6
Entrez ID		56288	4087
HPRD ID		05994	03221
Ensembl ID		ENSG00000148498	ENSG00000175387
Uniprot IDs		Q8TEW0	B7Z5N5 Q15796 Q53XR6
PDB IDs		2KOM	1DEV 1KHX 1U7V 2LB3 5XOD 5ZOJ 6H3R 6M64 6YIA 6ZVQ 7CO1
Enriched GO Terms of Interacting Partners?		Heteromeric SMAD Protein Complex Intracellular Signal Transduction I-SMAD Binding Tight Junction PAR Polarity Complex Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity SMAD Protein Complex Establishment Or Maintenance Of Apical/basal Cell Polarity SMAD Protein Signal Transduction Cell-cell Junction Organization Cytosol Protein-containing Complex Establishment Or Maintenance Of Cell Polarity Mesonephric Tubule Development Mesonephric Epithelium Development Identical Protein Binding Cytoplasm Regulation Of Cellular Component Organization Bicellular Tight Junction Tube Development Kidney Epithelium Development Positive Regulation Of Cell Differentiation Endoderm Development Regulation Of Protein Localization Anchoring Junction Ureteric Bud Development Co-SMAD Binding Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Localization Primary MiRNA Processing Golgi Localization Cell Junction Organization Intracellular Protein Localization Extracellular Exosome Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Transport Homomeric SMAD Protein Complex Cardiac Conduction System Development Regulation Of Cell Differentiation Intracellular Signaling Cassette Regulation Of Signaling Regulation Of Cell Communication Regulation Of Transport Signal Transduction Embryonic Pattern Specification Epithelium Development Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Cellular Localization Transcription Regulator Complex Response To Monosaccharide	Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Nucleoplasm SMAD Binding Regulation Of Signal Transduction Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of Cell Communication Positive Regulation Of Macromolecule Metabolic Process Regulation Of Signaling Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Transcription Regulator Complex Regulation Of Primary Metabolic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Communication Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Signaling Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Developmental Process Positive Regulation Of Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Intracellular Signal Transduction Chromatin Negative Regulation Of Signaling Negative Regulation Of Cell Communication Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process
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