PARD3 and PARD6G

Number of citations of the paper that reports this interaction (PMID 12459187)
12

Data Source:
HPRD (in vitro, in vivo)

		PARD3	PARD6G
Gene Name		par-3 family cell polarity regulator	par-6 family cell polarity regulator gamma
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Spindle Cytosol Plasma Membrane Cell-cell Junction Cell-cell Adherens Junction Tight Junction Cell Cortex Endomembrane System Cell Junction Internode Region Of Axon Neuronal Cell Body Protein Complex Axonal Growth Cone Apical Part Of Cell	Cytosol Plasma Membrane Tight Junction Protein Complex
	Molecular Function	Protein Kinase C Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Protein Phosphatase Binding Phosphatidylinositol-3-phosphate Binding	Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Apical Constriction Protein Complex Assembly Protein Targeting To Membrane Cell Cycle Establishment Or Maintenance Of Cell Polarity Transforming Growth Factor Beta Receptor Signaling Pathway Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Axonogenesis Asymmetric Cell Division Negative Regulation Of Peptidyl-threonine Phosphorylation Myelination In Peripheral Nervous System Positive Regulation Of Myelination Regulation Of Actin Filament-based Process Cell Junction Assembly Wound Healing, Spreading Of Cells Cell-cell Junction Organization Centrosome Localization Regulation Of Cellular Localization Tight Junction Assembly Establishment Of Epithelial Cell Polarity	Cell Cycle Cell Junction Assembly Cell-cell Junction Organization Cell Division Tight Junction Assembly
Pathways		Loss of Function of TGFBR2 in Cancer Cell junction organization TGFBR2 MSI Frameshift Mutants in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer Tight junction interactions Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Cell-cell junction organization Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer	Cell junction organization Cell-cell junction organization Tight junction interactions
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 19684603) Emphysema-related traits ( 20709820) Major depressive disorder ( 21621269) Schizophrenia ( 21682944)
Protein-Protein Interactions		27 interactors: CDC42 DYNLL1 F11R INADL INSC LIMK2 PARD6A PARD6B PARD6G PLCB1 PLCB3 PNMA1 PRKCG PRKCI PVRL1 PVRL3 SMAD2 SMAD3 SMAD4 SMAD7 STK11 TIAM1 TIAM2 YWHAB YWHAG YWHAH YWHAZ	5 interactors: CDC42 PARD3 PRKCI PRKCZ RAC1
Entrez ID		56288	84552
HPRD ID		05994	10138
Ensembl ID		ENSG00000148498	ENSG00000178184
Uniprot IDs		Q8TEW0	Q9BYG4
PDB IDs		2KOM
Enriched GO Terms of Interacting Partners?		Cell-cell Junction Organization Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Cell Junction Assembly Cellular Response To Growth Factor Stimulus Cellular Component Assembly Tight Junction Assembly Positive Regulation Of Apoptotic Process Response To Growth Factor Regulation Of Cellular Component Organization Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Intracellular Transport Apical Junction Assembly Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Signal Transduction Cellular Response To Organic Substance Regulation Of Cell Death Positive Regulation Of Transport Cell-cell Junction Assembly Signaling Positive Regulation Of Mitochondrion Organization Cell Communication Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Development Regulation Of Intracellular Transport Regulation Of Apoptotic Process Positive Regulation Of Cell Morphogenesis Involved In Differentiation System Development Regulation Of Establishment Of Protein Localization Nervous System Development Regulation Of Cell Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Anatomical Structure Development Regulation Of Signal Transduction Response To Transforming Growth Factor Beta Positive Regulation Of Signal Transduction Intrinsic Apoptotic Signaling Pathway SMAD Protein Complex Assembly Regulation Of Mitochondrion Organization Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Cellular Localization Response To Organic Substance Regulation Of Protein Localization Multicellular Organismal Development	Establishment Or Maintenance Of Cell Polarity Actin Filament-based Process Cell-cell Junction Organization Cell Migration Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Neuron Development Neuron Differentiation Cytoskeleton Organization Protein Localization To Membrane Locomotion Cellular Protein Localization Vascular Endothelial Growth Factor Receptor Signaling Pathway Establishment Of Cell Polarity Positive Regulation Of Cell-substrate Adhesion Movement Of Cell Or Subcellular Component Generation Of Neurons Neurogenesis Cellular Response To Growth Factor Stimulus Actin Cytoskeleton Organization Wound Healing Response To Growth Factor Neuron Projection Morphogenesis Cell Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Component Assembly Protein Localization Response To Wounding Regulation Of Cell-substrate Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Epithelial Cell Development Neuron Projection Development Cell Projection Morphogenesis Membrane Organization Positive Regulation Of Cell Differentiation Cell Part Morphogenesis Nervous System Development Positive Regulation Of Cell-cell Adhesion Cellular Localization Establishment Or Maintenance Of Apical/basal Cell Polarity Anatomical Structure Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell Projection Organization Regulation Of T Cell Activation Regulation Of Cellular Localization Positive Regulation Of Cell Activation Regulation Of Substrate Adhesion-dependent Cell Spreading Cell Morphogenesis
Tagcloud ?		antisaccade assayed blink disrupt eeg electrodermal endophenotype endophenotypes exome exonic eye illumina kernel maf mapped movements neutral nonsynonymous pleasant pnpla7 polymorphic psychophysiological rare resting snp snps startle technologies theta
Tagcloud (Difference) ?		antisaccade assayed blink disrupt eeg electrodermal endophenotype endophenotypes exome exonic eye illumina kernel maf mapped movements neutral nonsynonymous pleasant pnpla7 polymorphic psychophysiological rare resting snp snps startle technologies theta
Tagcloud (Intersection) ?