PARD3 and LIMK2

Number of citations of the paper that reports this interaction (PMID 16505165)
23

Data Source:
HPRD (in vivo, in vitro)

		PARD3	LIMK2
Gene Name		par-3 family cell polarity regulator	LIM domain kinase 2
Image
Gene Ontology Annotations	Cellular Component	Spindle Cytosol Plasma Membrane Cell-cell Junction Cell-cell Adherens Junction Tight Junction Cell Cortex Endomembrane System Cell Junction Internode Region Of Axon Neuronal Cell Body Protein Complex Axonal Growth Cone Apical Part Of Cell	Nucleus Cytoplasm Cis-Golgi Network
	Molecular Function	Protein Kinase C Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Protein Phosphatase Binding Phosphatidylinositol-3-phosphate Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Protein Heterodimerization Activity
	Biological Process	Microtubule Cytoskeleton Organization Apical Constriction Protein Complex Assembly Protein Targeting To Membrane Cell Cycle Establishment Or Maintenance Of Cell Polarity Transforming Growth Factor Beta Receptor Signaling Pathway Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Axonogenesis Asymmetric Cell Division Negative Regulation Of Peptidyl-threonine Phosphorylation Myelination In Peripheral Nervous System Positive Regulation Of Myelination Regulation Of Actin Filament-based Process Cell Junction Assembly Wound Healing, Spreading Of Cells Cell-cell Junction Organization Centrosome Localization Regulation Of Cellular Localization Tight Junction Assembly Establishment Of Epithelial Cell Polarity	Protein Phosphorylation Spermatogenesis Phosphorylation
Pathways		Loss of Function of TGFBR2 in Cancer Cell junction organization TGFBR2 MSI Frameshift Mutants in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer Tight junction interactions Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Cell-cell junction organization Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer	EPHB-mediated forward signaling Axon guidance Semaphorin interactions EPH-Ephrin signaling Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 19684603) Emphysema-related traits ( 20709820) Major depressive disorder ( 21621269) Schizophrenia ( 21682944)	Paclitaxel-induced neuropathy ( 23776197) Type 2 diabetes nephropathy ( 21150874)
Protein-Protein Interactions		27 interactors: CDC42 DYNLL1 F11R INADL INSC LIMK2 PARD6A PARD6B PARD6G PLCB1 PLCB3 PNMA1 PRKCG PRKCI PVRL1 PVRL3 SMAD2 SMAD3 SMAD4 SMAD7 STK11 TIAM1 TIAM2 YWHAB YWHAG YWHAH YWHAZ	9 interactors: CDC42BPA CFL1 GSN HIPK3 HIST1H1A LIMK1 MBP PARD3 ROCK1
Entrez ID		56288	3985
HPRD ID		05994	03585
Ensembl ID		ENSG00000148498	ENSG00000182541
Uniprot IDs		Q8TEW0	E7EUC1 P53671
PDB IDs		2KOM	1X6A
Enriched GO Terms of Interacting Partners?		Cell-cell Junction Organization Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Cell Junction Assembly Cellular Response To Growth Factor Stimulus Cellular Component Assembly Tight Junction Assembly Positive Regulation Of Apoptotic Process Response To Growth Factor Regulation Of Cellular Component Organization Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Intracellular Transport Apical Junction Assembly Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Signal Transduction Cellular Response To Organic Substance Regulation Of Cell Death Positive Regulation Of Transport Cell-cell Junction Assembly Signaling Positive Regulation Of Mitochondrion Organization Cell Communication Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Development Regulation Of Intracellular Transport Regulation Of Apoptotic Process Positive Regulation Of Cell Morphogenesis Involved In Differentiation System Development Regulation Of Establishment Of Protein Localization Nervous System Development Regulation Of Cell Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Anatomical Structure Development Regulation Of Signal Transduction Response To Transforming Growth Factor Beta Positive Regulation Of Signal Transduction Intrinsic Apoptotic Signaling Pathway SMAD Protein Complex Assembly Regulation Of Mitochondrion Organization Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Cellular Localization Response To Organic Substance Regulation Of Protein Localization Multicellular Organismal Development	Actin Filament-based Process Regulation Of Actin Filament-based Process Cytoskeleton Organization Actin Cytoskeleton Organization Rho Protein Signal Transduction Apical Constriction Ephrin Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Cell Projection Morphogenesis Cell Part Morphogenesis Neurogenesis Cell Morphogenesis Organelle Organization Regulation Of Cytoskeleton Organization Axonogenesis Cell Projection Organization Axon Development Cell Morphogenesis Involved In Neuron Differentiation Locomotion Positive Regulation Of Cytoskeleton Organization Nervous System Development Protein Phosphorylation Neuron Projection Morphogenesis Ras Protein Signal Transduction Cell Morphogenesis Involved In Differentiation Movement Of Cell Or Subcellular Component Actin-mediated Cell Contraction Generation Of Neurons Neuron Projection Development Cell Migration Epithelial Cell Morphogenesis Positive Regulation Of Cellular Component Biogenesis Regulation Of Cellular Component Size Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Regulation Of Organelle Organization Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Actin Filament-based Movement Cell Development Regulation Of Stress Fiber Assembly Response To External Stimulus Regulation Of Actin Filament Depolymerization Phosphorylation Neuron Development Intracellular Signal Transduction Regulation Of Neuron Projection Development Regulation Of Cellular Component Organization Axon Guidance Execution Phase Of Apoptosis Positive Regulation Of Organelle Organization
Tagcloud ?		antisaccade assayed blink disrupt eeg electrodermal endophenotype endophenotypes exome exonic eye illumina kernel maf mapped movements neutral nonsynonymous pleasant pnpla7 polymorphic psychophysiological rare resting snp snps startle technologies theta	aberrant cdk4 cofilin cyclin d1 death downregulation drp1 dynamic effectors epilepticus fission interacting kip1 mediators necrotic neuronal p27 programmed rescue rho rock se subsequently turn unsuspected upregulated vulnerable
Tagcloud (Difference) ?		antisaccade assayed blink disrupt eeg electrodermal endophenotype endophenotypes exome exonic eye illumina kernel maf mapped movements neutral nonsynonymous pleasant pnpla7 polymorphic psychophysiological rare resting snp snps startle technologies theta	aberrant cdk4 cofilin cyclin d1 death downregulation drp1 dynamic effectors epilepticus fission interacting kip1 mediators necrotic neuronal p27 programmed rescue rho rock se subsequently turn unsuspected upregulated vulnerable
Tagcloud (Intersection) ?