AGO1 and DCP2

Number of citations of the paper that reports this interaction (PubMedID 15937477)
30

Data Source:
HPRD (in vivo)

		AGO1	DCP2
Description		argonaute RISC component 1	decapping mRNA 2
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GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Cytosol RISC Complex Cytoplasmic Ribonucleoprotein Granule RISC-loading Complex Ribonucleoprotein Complex	P-body Nucleus Nucleoplasm Cytoplasm Cytosol RISC Complex Cell Junction Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Complex Binding Core Promoter Sequence-specific DNA Binding Nucleic Acid Binding RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding RNA Endonuclease Activity Protein Binding MiRNA Binding	RNA Binding 5'-3' RNA Exonuclease Activity Protein Binding Hydrolase Activity RNA Exonuclease Activity, Producing 5'-phosphomonoesters Manganese Ion Binding Metal Ion Binding Telomerase RNA Binding 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process Regulation Of Translation MiRNA Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Angiogenesis Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MiRNA Processing MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of MRNA Stability Positive Regulation Of Transcription By RNA Polymerase II RISC Complex Assembly SiRNA-mediated Gene Silencing By MRNA Destabilization Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA MRNA Catabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of MRNA Stability Histone MRNA Catabolic Process Regulation Of Telomerase RNA Localization To Cajal Body
Pathways		Pre-NOTCH Transcription and Translation MicroRNA (miRNA) biogenesis Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Small interfering RNA (siRNA) biogenesis Post-transcriptional silencing by small RNAs Transcriptional regulation by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Nuclear events stimulated by ALK signaling in cancer Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH1 mRNA translation by microRNAs Regulation of NPAS4 mRNA translation Regulation of MITF-M-dependent genes involved in apoptosis TGFBR3 expression Regulation of PD-L1(CD274) translation	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA
Drugs
Diseases
GWAS		Fasting glucose ( 34074324)	Waist circumference ( 32902719) Worry/vulnerability (special factor of neuroticism) ( 30867560)
Interacting Genes		9 interacting genes: AGO2 APP DCP1A DCP2 DICER1 KHDRBS1 LTN1 PRNP RELA	12 interacting genes: AGO1 AGO2 DCP1A DCP1B MIR15B MTOR NAGK POLA2 PSMB1 TRIM21 UPF1 UPF2
Entrez ID		26523	167227
HPRD ID		06942	13125
Ensembl ID		ENSG00000092847	ENSG00000172795
Uniprot IDs		A0A6I8PTZ8 B2RAD8 B3KME0 Q5TA58 Q9UL18	Q8IU60
PDB IDs		1SI2 1SI3 4KRE 4KRF 4KXT 5W6V	5MP0 5QOH 5QOI 5QOJ 5QOK 5QOL 5QOM 5QON 5QOO 5QOP 5QOQ 5QOR 5QOS 5QOT 5QOU 5QOV 5QOW 5QOX 5QOY 5QOZ 5QP0 5QP1 5QP2 5QP3 5QP4 5QP5 5QP6 5QP7 5QP8 5QP9 5QPA 5QPB 5QPC
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Schwann Cell Differentiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Schwann Cell Differentiation RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism Negative Regulation Of Macromolecule Metabolic Process Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Metabolic Process Post-transcriptional Regulation Of Gene Expression RISC-loading Complex SiRNA Processing Cytoplasmic Ribonucleoprotein Granule RISC Complex Assembly RISC Complex 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity SiRNA Binding P-body Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Negative Regulation Of Long-term Synaptic Potentiation RNA Metabolic Process Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Negative Regulation Of RNA Metabolic Process Pre-miRNA Processing Intracellular Copper Ion Homeostasis Cytosol MRNA Methylguanosine-cap Decapping Copper Ion Homeostasis RNA Decapping Negative Regulation Of Transcription By RNA Polymerase II Dendrite Cellular Response To Copper Ion MiRNA Metabolic Process Molecular Function Activator Activity Positive Regulation Of Amyloid Precursor Protein Catabolic Process Macromolecule Catabolic Process Negative Regulation Of MiRNA Transcription RNA Catabolic Process Response To Copper Ion MiRNA Processing Nucleic Acid Metabolic Process RNA Endonuclease Activity Positive Regulation Of Glial Cell Differentiation Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Postsynapse Neuron Projection Organization Regulation Of Gene Expression Regulation Of Long-term Synaptic Potentiation	P-body Nuclear-transcribed MRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Catabolic Process MRNA Catabolic Process Macromolecule Catabolic Process RNA Catabolic Process Cytoplasmic Ribonucleoprotein Granule SiRNA-mediated Gene Silencing By MRNA Destabilization Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Negative Regulation Of Gene Expression Positive Regulation Of Catabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation RISC-loading Complex Negative Regulation Of Protein Metabolic Process Nucleobase-containing Compound Catabolic Process Negative Regulation Of Translation RISC Complex Assembly 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity Cytosol Regulation Of Translation RNA Metabolic Process Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Pre-miRNA Processing RISC Complex Autophagosome Assembly Regulation Of Trophoblast Cell Migration MRNA Methylguanosine-cap Decapping MRNA Destabilization Core Promoter Sequence-specific DNA Binding Nucleobase-containing Compound Metabolic Process Autophagosome Organization Negative Regulation Of Macromolecule Metabolic Process RNA Destabilization Regulation Of Non-canonical NF-kappaB Signal Transduction RNA Decapping Exon-exon Junction Complex MiRNA-mediated Post-transcriptional Gene Silencing Positive Regulation Of MRNA Catabolic Process MiRNA Metabolic Process Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Negative Regulation Of Metabolic Process Telomeric DNA Binding Post-transcriptional Gene Silencing Post-transcriptional Regulation Of Gene Expression MRNA Metabolic Process RNA Polymerase II Complex Binding Positive Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process MiRNA Processing
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