AGO1

Gene Name		argonaute RISC catalytic component 1
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Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Nucleoplasm Cytoplasm Cytosol Polysome Ribonucleoprotein Complex Micro-ribonucleoprotein Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Binding Endoribonuclease Activity Protein Binding MiRNA Binding Poly(A) RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process Transcription, DNA-templated Epidermal Growth Factor Receptor Signaling Pathway Notch Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Gene Expression MiRNA Metabolic Process Posttranscriptional Gene Silencing Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Fc-epsilon Receptor Signaling Pathway Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Regulatory RNA pathways Cellular Senescence Signaling by Wnt Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade Pre-NOTCH Transcription and Translation Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by NOTCH MicroRNA (miRNA) biogenesis Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System PIP3 activates AKT signaling Oncogene Induced Senescence PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Pre-NOTCH Expression and Processing Post-transcriptional silencing by small RNAs Innate Immune System Transcriptional regulation by small RNAs Signalling by NGF Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer beta-catenin independent WNT signaling Signaling by FGFR Ca2+ pathway Oxidative Stress Induced Senescence Small interfering RNA (siRNA) biogenesis
Drugs
Diseases
GWAS
Protein-protein Interactions		7 interactors: AGO2 DCP1A DCP2 DICER1 KHDRBS1 PRNP RELA
Entrez ID		26523
HPRD ID		06942
Ensembl ID		ENSG00000092847
Uniprot IDs		Q5TA58 Q9UL18
PDB IDs		1SI2 1SI3 4KRE 4KRF 4KXT
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Schwann Cell Differentiation Regulation Of Schwann Cell Differentiation Positive Regulation Of MiRNA Metabolic Process RNA Phosphodiester Bond Hydrolysis Regulation Of MiRNA Metabolic Process RNA Interference Pre-miRNA Processing MRNA Metabolic Process Production Of MiRNAs Involved In Gene Silencing By MiRNA Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RNA Metabolic Process Gene Silencing By MiRNA Positive Regulation Of Glial Cell Differentiation Cellular Response To DsRNA Posttranscriptional Gene Silencing Gene Expression Nucleic Acid Phosphodiester Bond Hydrolysis Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Gliogenesis Negative Regulation Of Cellular Metabolic Process Gene Silencing By RNA Cellular Response To Organic Cyclic Compound RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Regulation Of Translational Initiation Regulation Of Glial Cell Differentiation Response To DsRNA Aromatic Compound Catabolic Process Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Conversion Of Ds SiRNA To Ss SiRNA Involved In RNA Interference Hair Follicle Cell Proliferation Acetaldehyde Metabolic Process Conversion Of Ds SiRNA To Ss SiRNA Nucleobase-containing Compound Metabolic Process Hair Follicle Development Hair Cycle Process Negative Regulation Of Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Gliogenesis Gene Silencing Heterocycle Metabolic Process Hair Cycle Cellular Aromatic Compound Metabolic Process RNA Processing Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression MRNA Cleavage Involved In Gene Silencing By MiRNA Regulation Of Enamel Mineralization Peripheral Nervous System Myelin Formation
Tagcloud ?		argonaute cassette chip clusters constitutive crossing deep elongation enhancer enhancers exon explaining implication inclusion intergenic intragenic intronic microrna overlapping paradoxically prominent rather rnai rnas seq sirnas splicing syne2 unexpectedly