AGO1 and LTN1

Number of citations of the paper that reports this interaction (PubMedID 35325613)
0

Data Source:
BioGRID (protein complementation assay)

		AGO1	LTN1
Description		argonaute RISC component 1	listerin E3 ubiquitin protein ligase 1
Image
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Cytosol RISC Complex Cytoplasmic Ribonucleoprotein Granule RISC-loading Complex Ribonucleoprotein Complex	Cytoplasm Cytosol Cytosolic Ribosome RQC Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Complex Binding Core Promoter Sequence-specific DNA Binding Nucleic Acid Binding RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding RNA Endonuclease Activity Protein Binding MiRNA Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ribosomal Large Subunit Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process Regulation Of Translation MiRNA Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Angiogenesis Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MiRNA Processing MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of MRNA Stability Positive Regulation Of Transcription By RNA Polymerase II RISC Complex Assembly SiRNA-mediated Gene Silencing By MRNA Destabilization Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	Protein Ubiquitination Protein Autoubiquitination Rescue Of Stalled Ribosome Ribosome-associated Ubiquitin-dependent Protein Catabolic Process
Pathways		Pre-NOTCH Transcription and Translation MicroRNA (miRNA) biogenesis Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Small interfering RNA (siRNA) biogenesis Post-transcriptional silencing by small RNAs Transcriptional regulation by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Nuclear events stimulated by ALK signaling in cancer Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH1 mRNA translation by microRNAs Regulation of NPAS4 mRNA translation Regulation of MITF-M-dependent genes involved in apoptosis TGFBR3 expression Regulation of PD-L1(CD274) translation	Antigen processing: Ubiquitination & Proteasome degradation Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS		Fasting glucose ( 34074324)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Hip circumference ( 28552196) Immature fraction of reticulocytes ( 32888494) Initial pursuit acceleration in psychotic disorders ( 29064472) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)
Interacting Genes		9 interacting genes: AGO2 APP DCP1A DCP2 DICER1 KHDRBS1 LTN1 PRNP RELA	9 interacting genes: AGO1 HES4 IRF7 STING1 TIRAP UBC UBE2D1 UBE2D2 UBE2L3
Entrez ID		26523	26046
HPRD ID		06942	10327
Ensembl ID		ENSG00000092847	ENSG00000198862
Uniprot IDs		A0A6I8PTZ8 B2RAD8 B3KME0 Q5TA58 Q9UL18	O94822
PDB IDs		1SI2 1SI3 4KRE 4KRF 4KXT 5W6V	3J92
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Schwann Cell Differentiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Schwann Cell Differentiation RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism Negative Regulation Of Macromolecule Metabolic Process Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Metabolic Process Post-transcriptional Regulation Of Gene Expression RISC-loading Complex SiRNA Processing Cytoplasmic Ribonucleoprotein Granule RISC Complex Assembly RISC Complex 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity SiRNA Binding P-body Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Negative Regulation Of Long-term Synaptic Potentiation RNA Metabolic Process Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Negative Regulation Of RNA Metabolic Process Pre-miRNA Processing Intracellular Copper Ion Homeostasis Cytosol MRNA Methylguanosine-cap Decapping Copper Ion Homeostasis RNA Decapping Negative Regulation Of Transcription By RNA Polymerase II Dendrite Cellular Response To Copper Ion MiRNA Metabolic Process Molecular Function Activator Activity Positive Regulation Of Amyloid Precursor Protein Catabolic Process Macromolecule Catabolic Process Negative Regulation Of MiRNA Transcription RNA Catabolic Process Response To Copper Ion MiRNA Processing Nucleic Acid Metabolic Process RNA Endonuclease Activity Positive Regulation Of Glial Cell Differentiation Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Postsynapse Neuron Projection Organization Regulation Of Gene Expression Regulation Of Long-term Synaptic Potentiation	Ubiquitin Conjugating Enzyme Activity Regulation Of Interferon-beta Production Positive Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Type I Interferon Production Post-translational Protein Modification Regulation Of RNA Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Catabolic Process Nucleoplasm Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Interferon-beta Production Activation Of Innate Immune Response Catabolic Process Protein Ubiquitination Proteolysis Modification-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Innate Immune Response Regulation Of RNA Biosynthetic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Modification By Small Protein Conjugation Protein Polyubiquitination Ubiquitin-protein Transferase Activity Transcription Coactivator Activity Positive Regulation Of Ribosome Biogenesis Positive Regulation Of Pattern Recognition Receptor Signaling Pathway TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Interleukin-15 Production Cyclic-di-GMP Binding STING Complex Positive Regulation Of Response To Cytokine Stimulus Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Immune Response-activating Signaling Pathway Signaling Adaptor Activity Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Primary Metabolic Process Establishment Of Viral Latency Regulation Of Transcription By RNA Polymerase II Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway 2',3'-cyclic GMP-AMP Binding Positive Regulation Of Type I Interferon Production Protein Modification Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?