AGO1 and DCP1A

Number of citations of the paper that reports this interaction (PMID 15937477)
320

Data Source:
HPRD (in vivo)

		AGO1	DCP1A
Gene Name		argonaute RISC catalytic component 1	decapping mRNA 1A
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Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Nucleoplasm Cytoplasm Cytosol Polysome Ribonucleoprotein Complex Micro-ribonucleoprotein Complex	Cytoplasmic MRNA Processing Body Nucleus Cytosol Membrane
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Binding Endoribonuclease Activity Protein Binding MiRNA Binding Poly(A) RNA Binding	Protein Binding Hydrolase Activity Identical Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process Transcription, DNA-templated Epidermal Growth Factor Receptor Signaling Pathway Notch Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Gene Expression MiRNA Metabolic Process Posttranscriptional Gene Silencing Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Fc-epsilon Receptor Signaling Pathway Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Regulatory RNA pathways Cellular Senescence Signaling by Wnt Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade Pre-NOTCH Transcription and Translation Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by NOTCH MicroRNA (miRNA) biogenesis Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System PIP3 activates AKT signaling Oncogene Induced Senescence PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Pre-NOTCH Expression and Processing Post-transcriptional silencing by small RNAs Innate Immune System Transcriptional regulation by small RNAs Signalling by NGF Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer beta-catenin independent WNT signaling Signaling by FGFR Ca2+ pathway Oxidative Stress Induced Senescence Small interfering RNA (siRNA) biogenesis	Regulation of mRNA stability by proteins that bind AU-rich elements mRNA decay by 5' to 3' exoribonuclease Tristetraprolin (TTP) destabilizes mRNA Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS			Heart rate ( 23583979)
Protein-Protein Interactions		7 interactors: AGO2 DCP1A DCP2 DICER1 KHDRBS1 PRNP RELA	14 interactors: AGO1 AGO2 DCP2 FHL2 LSM8 MAPK3 PAXIP1 PNRC2 RITA1 SMAD4 TTF2 UPF1 XRN1 YWHAG
Entrez ID		26523	55802
HPRD ID		06942	06113
Ensembl ID		ENSG00000092847	ENSG00000162290
Uniprot IDs		Q5TA58 Q9UL18	B4DHN9 Q9NPI6 U3KQU1
PDB IDs		1SI2 1SI3 4KRE 4KRF 4KXT	2WX3 4B6H
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Schwann Cell Differentiation Regulation Of Schwann Cell Differentiation Positive Regulation Of MiRNA Metabolic Process RNA Phosphodiester Bond Hydrolysis Regulation Of MiRNA Metabolic Process RNA Interference Pre-miRNA Processing MRNA Metabolic Process Production Of MiRNAs Involved In Gene Silencing By MiRNA Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RNA Metabolic Process Gene Silencing By MiRNA Positive Regulation Of Glial Cell Differentiation Cellular Response To DsRNA Posttranscriptional Gene Silencing Gene Expression Nucleic Acid Phosphodiester Bond Hydrolysis Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Gliogenesis Negative Regulation Of Cellular Metabolic Process Gene Silencing By RNA Cellular Response To Organic Cyclic Compound RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Regulation Of Translational Initiation Regulation Of Glial Cell Differentiation Response To DsRNA Aromatic Compound Catabolic Process Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Conversion Of Ds SiRNA To Ss SiRNA Involved In RNA Interference Hair Follicle Cell Proliferation Acetaldehyde Metabolic Process Conversion Of Ds SiRNA To Ss SiRNA Nucleobase-containing Compound Metabolic Process Hair Follicle Development Hair Cycle Process Negative Regulation Of Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Gliogenesis Gene Silencing Heterocycle Metabolic Process Hair Cycle Cellular Aromatic Compound Metabolic Process RNA Processing Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression MRNA Cleavage Involved In Gene Silencing By MiRNA Regulation Of Enamel Mineralization Peripheral Nervous System Myelin Formation	MRNA Metabolic Process RNA Metabolic Process Gene Expression Histone MRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Nucleobase-containing Compound Metabolic Process Histone MRNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Aromatic Compound Catabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Transcription, DNA-templated RNA Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nucleic Acid Phosphodiester Bond Hydrolysis MiRNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Notch Signaling Pathway Positive Regulation Of Histone Acetylation Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Catabolic Process Positive Regulation Of Peptidyl-lysine Acetylation Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Regulation Of Protein Metabolic Process Positive Regulation Of Protein Acetylation Epidermal Growth Factor Receptor Signaling Pathway Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Nucleic Acid-templated Transcription Response To Fibroblast Growth Factor Regulation Of RNA Biosynthetic Process Gene Silencing By MiRNA Regulation Of RNA Metabolic Process
Tagcloud ?		argonaute cassette chip clusters constitutive crossing deep elongation enhancer enhancers exon explaining implication inclusion intergenic intragenic intronic microrna overlapping paradoxically prominent rather rnai rnas seq sirnas splicing syne2 unexpectedly	appears blockade bodies caf1 ccr4 cleavage coincident cytoplasmic decapping directed dispersion disrupts eif2alpha enter evh1 gfp infection infectious linking mammalian pan2 pan3 pkr poliovirus restricted restricts surprisingly translation translational
Tagcloud (Difference) ?		argonaute cassette chip clusters constitutive crossing deep elongation enhancer enhancers exon explaining implication inclusion intergenic intragenic intronic microrna overlapping paradoxically prominent rather rnai rnas seq sirnas splicing syne2 unexpectedly	appears blockade bodies caf1 ccr4 cleavage coincident cytoplasmic decapping directed dispersion disrupts eif2alpha enter evh1 gfp infection infectious linking mammalian pan2 pan3 pkr poliovirus restricted restricts surprisingly translation translational
Tagcloud (Intersection) ?