PRKX and PRKAR2A

Number of citations: 0 (PubMedID 10026146)
Data Source: HPRD (in vitro)

		PRKX	PRKAR2A
Name		protein kinase cAMP-dependent X-linked catalytic subunit	protein kinase cAMP-dependent type II regulatory subunit alpha
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol CAMP-dependent Protein Kinase Complex	Cytoplasm Centrosome Cytosol Plasma Membrane Focal Adhesion Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Protein-containing Complex Plasma Membrane Raft Extracellular Exosome Ciliary Base
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Nucleotide Binding CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Angiogenesis Endothelial Cell Proliferation Cell Adhesion Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Peptidyl-serine Phosphorylation Myeloid Cell Differentiation Cell Differentiation Regulation Of Cell Adhesion Regulation Of Cell Migration Cell-substrate Adhesion Endothelial Cell Migration Protein Autophosphorylation Epithelial Tube Morphogenesis Kidney Morphogenesis Regulation Of Epithelial Cell Differentiation Involved In Kidney Development	Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of CAMP/PKA Signal Transduction
Pathways		PKA-mediated phosphorylation of CREB CREB1 phosphorylation through the activation of Adenylate Cyclase ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis	PKA activation PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ROBO receptors bind AKAP5 GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		None	GEM-231
GWAS		Lymphocyte count ( 29403010 ) Thyroid stimulating hormone levels ( 30367059 )	Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Crohn's disease ( 28067908 ) Depressive symptom (depressed mood) (binary trait) ( 31530331 ) Depressive symptom (depressed mood) (ordinal trait) ( 31530331 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Heel bone mineral density ( 30598549 ) Height ( 31562340 ) Hip circumference adjusted for BMI ( 34021172 ) Inflammatory bowel disease ( 28067908 ) Lipoprotein (a) levels ( 33730874 ) Morning person ( 30696823 ) Resting heart rate ( 27798624 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Ulcerative colitis ( 28067908 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		5 interacting genes: NEDD4 NEDD4L PKIA PRKAR1A PRKAR2A	40 interacting genes: AKAP1 AKAP10 AKAP11 AKAP12 AKAP13 AKAP14 AKAP3 AKAP4 AKAP5 AKAP6 AKAP7 AKAP8 AKAP9 ARFGEF2 CBFA2T3 CDK1 CFTR EZR FOS IFNAR2 LRIF1 MAP2 MYCBPAP NBEA OGT PJA2 PPP1CB PRKACA PRKX RAB32 RACK1 RET RUNX1T1 RYR2 SCTR SEMG2 SMAD3 SMAD4 WASF1 WEE2-AS1
Entrez ID		5613	5576
HPRD ID		02097	01484
Ensembl ID		ENSG00000183943	ENSG00000114302
Uniprot IDs		P51817	A0A024R2W3 A0A0S2Z472 A0A9L9PY56 A8KAH7 P13861
PDB IDs		Not available	2IZX 2KYG 4ZP3 5H78 5XBY 8S8O
GO Terms Enriched among Interactors		CAMP-dependent Protein Kinase Inhibitor Activity Protein Kinase A Catalytic Subunit Binding Negative Regulation Of CAMP/PKA Signal Transduction Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Potassium Ion Export Across Plasma Membrane CAMP-dependent Protein Kinase Regulator Activity Sodium Channel Inhibitor Activity Potassium Channel Inhibitor Activity CAMP-dependent Protein Kinase Complex Nucleotide-activated Protein Kinase Complex Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Sodium Ion Transport Receptor Catabolic Process CAMP Binding Negative Regulation Of Potassium Ion Transmembrane Transport Protein Domain Specific Binding Negative Regulation Of Potassium Ion Transport Plasma Membrane Raft Neuromuscular Junction Development Ciliary Base Receptor Metabolic Process Multivesicular Body Protein Monoubiquitination Regulation Of Dendrite Morphogenesis Negative Regulation Of Transport Regulation Of Potassium Ion Transmembrane Transport Receptor Internalization Negative Regulation Of Cation Transmembrane Transport Regulation Of Sodium Ion Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Signal Transduction Regulation Of Potassium Ion Transport Negative Regulation Of Cell Communication Negative Regulation Of Signaling Formation Of Structure Involved In A Symbiotic Process Negative Regulation Of CAMP-dependent Protein Kinase Activity Regulation Of Dendrite Development Regulation Of Transport Negative Regulation Of Monoatomic Ion Transport Negative Regulation Of Transmembrane Transport Regulation Of Nucleocytoplasmic Transport Axoneme Channel Inhibitor Activity Transmembrane Transporter Binding Regulation Of Intracellular Signal Transduction Protein-containing Complex Negative Regulation Of Intracellular Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phosphothreonine Residue Binding Negative Regulation Of Sodium Ion Import Across Plasma Membrane	Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding Regulation Of Protein Kinase A Signaling CAMP-dependent Protein Kinase Complex Cellular Response To Oxygen-containing Compound Positive Regulation Of Intracellular Transport Response To Purine-containing Compound Response To CAMP Positive Regulation Of Transport Positive Regulation Of Protein Localization Cellular Response To CAMP Regulation Of Protein Catabolic Process Cellular Response To Glucose Stimulus Signal Transduction Regulation Of Cellular Localization Cellular Response To Carbohydrate Stimulus Intracellular Signaling Cassette Intracellular Signal Transduction Adenylate Cyclase Binding Intracellular Glucose Homeostasis Positive Regulation Of Protein Transport Regulation Of Protein Localization Protein Kinase A Catalytic Subunit Binding Regulation Of Intracellular Transport Molecular Adaptor Activity GABA Receptor Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Sperm Capacitation Left Ventricular Cardiac Muscle Tissue Morphogenesis Dendritic Branch Response To Glucose Positive Regulation Of Establishment Of Protein Localization Protein Kinase Binding Response To Monosaccharide Positive Regulation Of Protein Kinase A Signaling SMAD Protein Signal Transduction MAPK Cascade Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Calcium Channel Complex R-SMAD Binding Multicellular Organismal-level Water Homeostasis Membrane To Membrane Docking Regulation Of Multicellular Organismal Process Regulation Of Transport Response To Carbohydrate Intracellular Chemical Homeostasis Negative Regulation Of Cell Growth CAMP-dependent Protein Kinase Activity Positive Regulation Of Intracellular Protein Transport Cellular Response To Growth Factor Stimulus