PRKX

Description		protein kinase cAMP-dependent X-linked catalytic subunit
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol CAMP-dependent Protein Kinase Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Angiogenesis Endothelial Cell Proliferation Cell Adhesion Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Peptidyl-serine Phosphorylation Myeloid Cell Differentiation Cell Differentiation Regulation Of Cell Adhesion Regulation Of Cell Migration Cell-substrate Adhesion Endothelial Cell Migration Protein Autophosphorylation Epithelial Tube Morphogenesis Kidney Morphogenesis Regulation Of Epithelial Cell Differentiation Involved In Kidney Development
Pathways		PKA-mediated phosphorylation of CREB CREB1 phosphorylation through the activation of Adenylate Cyclase ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis
Drugs
Diseases
GWAS		Lymphocyte count ( 29403010) Thyroid stimulating hormone levels ( 30367059)
Interacting Genes		5 interacting genes: NEDD4 NEDD4L PKIA PRKAR1A PRKAR2A
Entrez ID		5613
HPRD ID		02097
Ensembl ID		ENSG00000183943
Uniprot IDs		P51817
PDB IDs
Enriched GO Terms of Interacting Partners?		CAMP-dependent Protein Kinase Inhibitor Activity Protein Kinase A Catalytic Subunit Binding Negative Regulation Of CAMP/PKA Signal Transduction Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Potassium Ion Export Across Plasma Membrane CAMP-dependent Protein Kinase Regulator Activity Sodium Channel Inhibitor Activity Potassium Channel Inhibitor Activity CAMP-dependent Protein Kinase Complex Nucleotide-activated Protein Kinase Complex Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Sodium Ion Transport Receptor Catabolic Process CAMP Binding Negative Regulation Of Potassium Ion Transmembrane Transport Protein Domain Specific Binding Negative Regulation Of Potassium Ion Transport Plasma Membrane Raft Neuromuscular Junction Development Ciliary Base Receptor Metabolic Process Multivesicular Body Protein Monoubiquitination Regulation Of Dendrite Morphogenesis Negative Regulation Of Transport Regulation Of Potassium Ion Transmembrane Transport Receptor Internalization Negative Regulation Of Cation Transmembrane Transport Regulation Of Sodium Ion Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Signal Transduction Regulation Of Potassium Ion Transport Negative Regulation Of Cell Communication Negative Regulation Of Signaling Formation Of Structure Involved In A Symbiotic Process Negative Regulation Of CAMP-dependent Protein Kinase Activity Regulation Of Dendrite Development Regulation Of Transport Negative Regulation Of Monoatomic Ion Transport Negative Regulation Of Transmembrane Transport Regulation Of Nucleocytoplasmic Transport Axoneme Channel Inhibitor Activity Transmembrane Transporter Binding Regulation Of Intracellular Signal Transduction Protein-containing Complex Negative Regulation Of Intracellular Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phosphothreonine Residue Binding Negative Regulation Of Sodium Ion Import Across Plasma Membrane
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