PRKX and PRKAR1A

Number of citations: 0 (PubMedID 10026146)
Data Source: HPRD (in vitro, in vivo)

		PRKX	PRKAR1A
Name		protein kinase cAMP-dependent X-linked catalytic subunit	protein kinase cAMP-dependent type I regulatory subunit alpha
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol CAMP-dependent Protein Kinase Complex	Immunological Synapse Cytoplasm Multivesicular Body Centrosome Cytosol Plasma Membrane Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Neuromuscular Junction Protein-containing Complex Plasma Membrane Raft Synapse Ciliary Base Glutamatergic Synapse Sperm Head-tail Coupling Apparatus
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Nucleotide Binding CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Angiogenesis Endothelial Cell Proliferation Cell Adhesion Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Peptidyl-serine Phosphorylation Myeloid Cell Differentiation Cell Differentiation Regulation Of Cell Adhesion Regulation Of Cell Migration Cell-substrate Adhesion Endothelial Cell Migration Protein Autophosphorylation Epithelial Tube Morphogenesis Kidney Morphogenesis Regulation Of Epithelial Cell Differentiation Involved In Kidney Development	Mesoderm Formation Regulation Of Transcription By RNA Polymerase II Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heart Development Negative Regulation Of Gene Expression Positive Regulation Of Insulin Secretion Intracellular Signal Transduction Sarcomere Organization Negative Regulation Of Activated T Cell Proliferation Cardiac Muscle Cell Proliferation Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP/PKA Signal Transduction
Pathways		PKA-mediated phosphorylation of CREB CREB1 phosphorylation through the activation of Adenylate Cyclase ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis	PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		None	(Rp)-cAMPS Cyclic GMP Cyclic adenosine monophosphate GEM-231
Diseases		None	Pigmented micronodular adrenocortical disease (PPNAD)
GWAS		Lymphocyte count ( 29403010 ) Thyroid stimulating hormone levels ( 30367059 )	Body size at age 10 ( 32376654 ) Coronary artery disease ( 33020668 ) Estimated glomerular filtration rate ( 31152163 ) Intake of total sugars ( 31005972 ) Serum alkaline phosphatase levels ( 33547301 )
Interacting Genes		5 interacting genes: NEDD4 NEDD4L PKIA PRKAR1A PRKAR2A	55 interacting genes: AKAP1 AKAP10 AKAP11 AKAP19 AKAP4 AKAP5 AKAP7 AKT1 ARFGEF2 BAHD1 BTG3 CAPN11 CBS CCNE1 CDK2 CDK4 CSTPP1 DSCR4 DSCR9 DTX1 EGFR FAM153B GRB2 HIVEP1 HLA-A ITGA4 MAP1A MAP1B MAPK6 MYO7A NELL2 OGT PATZ1 PJA2 PLEKHF2 PRKACA PRKAR1B PRKX PRPF40A PSMG1 PYCARD RAF1 RFC2 RSPH3 SET SETD7 SLC2A4 SMAD2 SNCA SPART TAB1 WDCP WNK1 YWHAZ ZBED1
Entrez ID		5613	5573
HPRD ID		02097	01786
Ensembl ID		ENSG00000183943	ENSG00000108946
Uniprot IDs		P51817	B2R5T5 P10644
PDB IDs		Not available	5KJX 5KJY 5KJZ
GO Terms Enriched among Interactors		CAMP-dependent Protein Kinase Inhibitor Activity Protein Kinase A Catalytic Subunit Binding Negative Regulation Of CAMP/PKA Signal Transduction Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Potassium Ion Export Across Plasma Membrane CAMP-dependent Protein Kinase Regulator Activity Sodium Channel Inhibitor Activity Potassium Channel Inhibitor Activity CAMP-dependent Protein Kinase Complex Nucleotide-activated Protein Kinase Complex Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Sodium Ion Transport Receptor Catabolic Process CAMP Binding Negative Regulation Of Potassium Ion Transmembrane Transport Protein Domain Specific Binding Negative Regulation Of Potassium Ion Transport Plasma Membrane Raft Neuromuscular Junction Development Ciliary Base Receptor Metabolic Process Multivesicular Body Protein Monoubiquitination Regulation Of Dendrite Morphogenesis Negative Regulation Of Transport Regulation Of Potassium Ion Transmembrane Transport Receptor Internalization Negative Regulation Of Cation Transmembrane Transport Regulation Of Sodium Ion Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Signal Transduction Regulation Of Potassium Ion Transport Negative Regulation Of Cell Communication Negative Regulation Of Signaling Formation Of Structure Involved In A Symbiotic Process Negative Regulation Of CAMP-dependent Protein Kinase Activity Regulation Of Dendrite Development Regulation Of Transport Negative Regulation Of Monoatomic Ion Transport Negative Regulation Of Transmembrane Transport Regulation Of Nucleocytoplasmic Transport Axoneme Channel Inhibitor Activity Transmembrane Transporter Binding Regulation Of Intracellular Signal Transduction Protein-containing Complex Negative Regulation Of Intracellular Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phosphothreonine Residue Binding Negative Regulation Of Sodium Ion Import Across Plasma Membrane	Protein Kinase A Regulatory Subunit Binding CAMP-dependent Protein Kinase Complex Protein Kinase A Binding Protein Phosphorylation Cytosol Phosphorylation Protein-containing Complex Ubiquitin Protein Ligase Binding Cytoplasm Peptidyl-serine Phosphorylation Regulation Of Protein Localization To Cell Periphery Protein Serine Kinase Activity Intracellular Signal Transduction Regulation Of Biological Quality Signal Transduction Kinase Activity Protein Kinase Activity Cyclin E1-CDK2 Complex Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Serine/threonine Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation TORC1 Signaling Regulation Of Lymphocyte Migration Intracellular Signaling Cassette Postsynapse Cellular Response To Oxygen-containing Compound Protein Kinase Binding Intracellular Protein Localization Protein Domain Specific Binding Cell Surface Receptor Signaling Pathway Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Protein Localization To Cell Periphery ERBB Signaling Pathway Regulation Of Anaphase-promoting Complex-dependent Catabolic Process CAMP-dependent Protein Kinase Activity Establishment Of Protein Localization TOR Signaling Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of T Cell Migration Odontoblast Differentiation Regulation Of Protein Kinase A Signaling Organelle Organization Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Protein Localization To Membrane Enzyme Binding