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PRKRIR and DDX58
Number of citations of the paper that reports this interaction (PMID
21910972
)
0
Data Source:
BioGRID
(pull down)
PRKRIR
DDX58
Gene Name
protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Tight Junction
Actin Cytoskeleton
Ruffle Membrane
Molecular Function
DNA Binding
Metal Ion Binding
Protein Dimerization Activity
Double-stranded DNA Binding
Double-stranded RNA Binding
Single-stranded RNA Binding
Helicase Activity
Protein Binding
ATP Binding
Zinc Ion Binding
Identical Protein Binding
Biological Process
Response To Stress
Signal Transduction
Negative Regulation Of Cell Proliferation
Positive Regulation Of Defense Response To Virus By Host
Metabolic Process
Detection Of Virus
Response To Virus
Viral Process
Regulation Of Cell Migration
Negative Regulation Of Type I Interferon Production
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-beta Production
Regulation Of Type III Interferon Production
Cytoplasmic Pattern Recognition Receptor Signaling Pathway In Response To Virus
RIG-I Signaling Pathway
Positive Regulation Of Transcription Factor Import Into Nucleus
Response To Exogenous DsRNA
Innate Immune Response
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Pathways
TRAF3-dependent IRF activation pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Negative regulators of RIG-I/MDA5 signaling
ISG15 antiviral mechanism
Interferon Signaling
TRAF6 mediated IRF7 activation
Cytokine Signaling in Immune system
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Antiviral mechanism by IFN-stimulated genes
Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
7 interactors:
DDX58
DNAJC3
EIF2AK2
EIF2S1
STK4
TACC1
TP53
13 interactors:
CYLD
MAVS
PRKCG
PRKRIR
RNF135
TRIM25
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2K
USP3
WRNIP1
Entrez ID
5612
23586
HPRD ID
09567
13131
Ensembl ID
ENSG00000137492
ENSG00000107201
Uniprot IDs
O43422
B3KWW1
F5H5W6
O95786
PDB IDs
2LWD
2LWE
2QFB
2QFD
2RMJ
2YKG
3LRN
3LRR
3NCU
3OG8
3TMI
3ZD6
3ZD7
4AY2
4BPB
Enriched GO Terms of Interacting Partners
?
ER-nucleus Signaling Pathway
Response To Endoplasmic Reticulum Stress
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Phosphorylation
Positive Regulation Of Protein Modification Process
Endoplasmic Reticulum Unfolded Protein Response
Cellular Response To Unfolded Protein
Regulation Of Translational Initiation In Response To Stress
Cellular Response To Topologically Incorrect Protein
Regulation Of Protein Phosphorylation
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Kinase Activity
Response To Unfolded Protein
Positive Regulation Of Kinase Activity
Positive Regulation Of Protein Metabolic Process
Regulation Of Translation In Response To Stress
Regulation Of Phosphorylation
Positive Regulation Of Transferase Activity
Defense Response To Virus
Positive Regulation Of Cellular Metabolic Process
Regulation Of Phosphorus Metabolic Process
Protein Autophosphorylation
Regulation Of Protein Kinase Activity
Response To Biotic Stimulus
Regulation Of Kinase Activity
Response To Virus
Positive Regulation Of Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Activation Of Signaling Protein Activity Involved In Unfolded Protein Response
Positive Regulation Of Nuclease Activity
Immune System Process
Regulation Of Protein Metabolic Process
Regulation Of Catalytic Activity
Regulation Of Translational Initiation
Response To Organic Substance
Regulation Of Defense Response To Virus
Evasion Or Tolerance By Virus Of Host Immune Response
Viral Process
Regulation Of Apoptotic Process
Regulation Of Stem Cell Proliferation
Cellular Response To Stress
Positive Regulation Of Catalytic Activity
Regulation Of Cell Death
Negative Regulation Of Macromitophagy
Regulation Of Hematopoietic Stem Cell Differentiation
Oligodendrocyte Apoptotic Process
Signal Transduction
Negative Regulation Of Cell Proliferation
Negative Regulation Of Helicase Activity
RIG-I Signaling Pathway
Negative Regulation Of Type I Interferon Production
Regulation Of Type I Interferon Production
Response To Stress
Regulation Of Innate Immune Response
Innate Immune Response
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
Positive Regulation Of Innate Immune Response
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Negative Regulation Of Cytokine Production
Immune Response
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Defense Response
Protein K48-linked Ubiquitination
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Ubiquitination
Protein Catabolic Process
Protein Modification By Small Protein Conjugation
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of DNA-templated Transcription In Response To Stress
Protein Polyubiquitination
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Immune Response-regulating Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Cellular Macromolecule Catabolic Process
Regulation Of Immune Response
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Regulation Of Cytokine Production
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Immune System Process
Toll-like Receptor Signaling Pathway
Cellular Response To Oxygen Levels
Cellular Protein Modification Process
Positive Regulation Of Immune Response
Response To Stimulus
Regulation Of Protein Catabolic Process
Regulation Of Immune System Process
Cellular Response To Stimulus
Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of Immune System Process
Cellular Response To Stress
Proteolysis
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Tagcloud
?
adenovirus
apobec3a
exact
expand
hiv
ifi27
ifi44l
ifit1
ifit2
ifit3
innate
irf7
isg15
isg20
isgs
mdms
microarray
monocyte
mx1
mx2
reservoirs
rig
rsad2
select
stat1
tnfsf10
trail
viperin
vpr
Tagcloud (Difference)
?
adenovirus
apobec3a
exact
expand
hiv
ifi27
ifi44l
ifit1
ifit2
ifit3
innate
irf7
isg15
isg20
isgs
mdms
microarray
monocyte
mx1
mx2
reservoirs
rig
rsad2
select
stat1
tnfsf10
trail
viperin
vpr
Tagcloud (Intersection)
?