THAP12 and STK4

Number of citations of the paper that reports this interaction (PubMedID 24255178)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		THAP12	STK4
Description		THAP domain containing 12	serine/threonine kinase 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body Protein-containing Complex
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Protein Dimerization Activity	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein Serine Kinase Activity
	Biological Process	Signal Transduction Negative Regulation Of Cell Population Proliferation	Cell Morphogenesis Branching Involved In Blood Vessel Morphogenesis Neural Tube Formation Positive Regulation Of Protein Phosphorylation Endocardium Development Protein Phosphorylation Protein Import Into Nucleus Apoptotic Process Signal Transduction Central Nervous System Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Anatomical Structure Morphogenesis Peptidyl-serine Phosphorylation Keratinocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Organ Growth Hippo Signaling Positive Regulation Of Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of MAPK Cascade Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Organ Growth Protein Autophosphorylation Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Protein Stabilization Protein Tetramerization Canonical Wnt Signaling Pathway Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Hepatocyte Apoptotic Process Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate
Pathways			Signaling by Hippo
Drugs
Diseases
GWAS		Asthma ( 31959851) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189)	Bipolar disorder ( 31043756 33263727 34002096) Mean platelet volume ( 32888494) Platelet count ( 32888494)
Interacting Genes		10 interacting genes: DNAJC3 EIF2AK2 EIF2S1 KIAA1958 MAPKAPK3 RIGI STK4 TACC1 TP53 ZNF526	25 interacting genes: AKT1 CASP3 CNKSR1 CSN1S1 DAXX DDIT4L H2BC21 HSPA4 IL2RG KEAP1 LATS1 MBP NEDD4 OGT PICK1 RASSF1 RASSF5 RNF31 RNF6 SAV1 SGMS1 SIRT1 THAP12 TP53 TRIM69
Entrez ID		5612	6789
HPRD ID		09567	05395
Ensembl ID		ENSG00000137492	ENSG00000101109
Uniprot IDs		A0A140VJQ7 O43422	A0A087WVN8 Q13043
PDB IDs			2JO8 3COM 4NR2 4OH8 5TWG 5TWH 6YAT 8A5J 8PAV 8PAW
Enriched GO Terms of Interacting Partners?		Regulation Of Translation In Response To Endoplasmic Reticulum Stress Response To Endoplasmic Reticulum Stress Regulation Of Translational Initiation In Response To Stress Regulation Of Translational Initiation Positive Regulation Of Epithelial Cell Apoptotic Process Regulation Of Translation In Response To Stress Regulation Of Protein Metabolic Process Cellular Response To Starvation Negative Regulation Of Translation Intracellular Signal Transduction ER-nucleus Signaling Pathway Response To Starvation Negative Regulation Of Protein Metabolic Process Mitophagy Cellular Response To Amino Acid Starvation Regulation Of Epithelial Cell Apoptotic Process Translation Initiation Ternary Complex Cellular Response To Nutrient Levels Defense Response To Virus Positive Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Negative Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Positive Regulation Of Hepatocyte Apoptotic Process Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition MRNA Transcription Response To Amino Acid Starvation Endoplasmic Reticulum Unfolded Protein Response Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Autophagy Of Mitochondrion Double-stranded RNA Binding Translational Initiation Antiviral Innate Immune Response Protein Serine Kinase Activity Response To Manganese-induced Endoplasmic Reticulum Stress Glial Limiting End-foot Cellular Response To UV Cellular Response To Light Stimulus Regulation Of Translation Response To Virus Regulation Of Stem Cell Proliferation Protein Serine/threonine Kinase Activity Positive Regulation Of Translational Initiation In Response To Stress Protein-folding Chaperone Binding Negative Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Protein Tetramerization Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia	Apoptotic Process Programmed Cell Death Regulation Of Autophagy Cell Death Intracellular Signal Transduction Regulation Of Macroautophagy Response To Stress Regulation Of Proteolysis Identical Protein Binding Regulation Of Protein Metabolic Process Keratinocyte Differentiation Positive Regulation Of Protein Metabolic Process Response To UV Immune System Process Protein Modification Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Hippo Signaling Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Ubiquitination Regulation Of Programmed Cell Death Positive Regulation Of Proteolysis Regulation Of Glucose Metabolic Process Epidermal Cell Differentiation Glial Cell Apoptotic Process Regulation Of Programmed Necrotic Cell Death PML Body Keratin Filament Binding Signal Transduction Transcription Regulator Inhibitor Activity Positive Regulation Of Metabolic Process Regulation Of Endodeoxyribonuclease Activity Nucleus Regulation Of Post-translational Protein Modification T Cell Differentiation In Thymus Stress-induced Premature Senescence Protein Ubiquitination Post-translational Protein Modification Cytoplasm Regulation Of Hippo Signaling Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Nutrient Levels Leukocyte Apoptotic Process Cellular Response To Glucose Starvation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Modification Process Regulation Of Transcription By Glucose Cellular Response To Decreased Oxygen Levels Protein Polyubiquitination Protein Modification By Small Protein Conjugation Negative Regulation Of Signaling
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