THAP12 and TACC1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		THAP12	TACC1
Description		THAP domain containing 12	transforming acidic coiled-coil containing protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Membrane Midbody
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Protein Dimerization Activity	Transcription Coactivator Activity Protein Binding Nuclear Receptor Binding Nuclear Estrogen Receptor Binding Nuclear Glucocorticoid Receptor Binding Nuclear Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Nuclear Retinoid X Receptor Binding Nuclear Thyroid Hormone Receptor Binding
	Biological Process	Signal Transduction Negative Regulation Of Cell Population Proliferation	Microtubule Cytoskeleton Organization Mitotic Spindle Organization Nuclear Migration Cerebral Cortex Development Positive Regulation Of DNA-templated Transcription Cell Division
Pathways
Drugs
Diseases
GWAS		Asthma ( 31959851) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189)	Blond vs. brown/black hair color ( 30531825) Chronic mountain sickness ( 31417607) Midgestational circulating levels of PBDEs ( 28235828)
Interacting Genes		10 interacting genes: DNAJC3 EIF2AK2 EIF2S1 KIAA1958 MAPKAPK3 RIGI STK4 TACC1 TP53 ZNF526	20 interacting genes: AURKA AURKB BTRC ERCC4 FAM50B HTT ITSN2 KAT2A KDM1A LSM7 MEMO1 SH2D4A SNRPG STX5 TDRD7 THAP12 THRA YEATS4 ZFHX3 ZNF48
Entrez ID		5612	6867
HPRD ID		09567	10391
Ensembl ID		ENSG00000137492	ENSG00000147526
Uniprot IDs		A0A140VJQ7 O43422	B7Z3G3 E5RFM9 E7ET87 E7EVI4 O75410
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Translation In Response To Endoplasmic Reticulum Stress Response To Endoplasmic Reticulum Stress Regulation Of Translational Initiation In Response To Stress Regulation Of Translational Initiation Positive Regulation Of Epithelial Cell Apoptotic Process Regulation Of Translation In Response To Stress Regulation Of Protein Metabolic Process Cellular Response To Starvation Negative Regulation Of Translation Intracellular Signal Transduction ER-nucleus Signaling Pathway Response To Starvation Negative Regulation Of Protein Metabolic Process Mitophagy Cellular Response To Amino Acid Starvation Regulation Of Epithelial Cell Apoptotic Process Translation Initiation Ternary Complex Cellular Response To Nutrient Levels Defense Response To Virus Positive Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Negative Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Positive Regulation Of Hepatocyte Apoptotic Process Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition MRNA Transcription Response To Amino Acid Starvation Endoplasmic Reticulum Unfolded Protein Response Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Autophagy Of Mitochondrion Double-stranded RNA Binding Translational Initiation Antiviral Innate Immune Response Protein Serine Kinase Activity Response To Manganese-induced Endoplasmic Reticulum Stress Glial Limiting End-foot Cellular Response To UV Cellular Response To Light Stimulus Regulation Of Translation Response To Virus Regulation Of Stem Cell Proliferation Protein Serine/threonine Kinase Activity Positive Regulation Of Translational Initiation In Response To Stress Protein-folding Chaperone Binding Negative Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Protein Tetramerization Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia	Spliceosomal Tri-snRNP Complex Chromosome Passenger Complex Nucleoplasm Nucleus Regulation Of DNA Metabolic Process Cellular Response To UV Regulation Of Microtubule-based Process U2-type Prespliceosome P Granule Cellular Response To Light Stimulus Microtubule Cytoskeleton Organization Involved In Mitosis U12-type Spliceosomal Complex Regulation Of Signal Transduction By P53 Class Mediator Spindle Midzone Protein Serine/threonine/tyrosine Kinase Activity Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Component Organization Response To UV Cellular Response To Radiation Regulation Of Cell Division Peptidyl-lysine Glutarylation Histone Glutaryltransferase Activity Histone Succinyltransferase Activity Regulation Of Protein Stability Peptide Glutaryltransferase Activity U4/U6 X U5 Tri-snRNP Complex Spindle Microtubule Mitotic Spindle Pole Positive Regulation Of Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Negative Regulation Of Nucleobase-containing Compound Metabolic Process Midbody Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Locomotor Rhythm Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleotide-excision Repair Involved In Interstrand Cross-link Repair Regulation Of Organelle Organization Regulation Of Centrosome Cycle Regulation Of DNA Repair Chromatin Organization Histone H3K9 Acetyltransferase Activity Protein Destabilization Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity U2-type Precatalytic Spliceosome Cell Cycle G2/M Phase Transition Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly
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