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PRKRIR and EIF2S1
Number of citations of the paper that reports this interaction (PMID
9819435
)
156
Data Source:
HPRD
(in vivo, in vitro)
PRKRIR
EIF2S1
Gene Name
protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleus
Cytosol
Polysome
Eukaryotic Translation Initiation Factor 2 Complex
Eukaryotic Translation Initiation Factor 2B Complex
Cytoplasmic Stress Granule
Membrane
Extracellular Vesicular Exosome
Molecular Function
DNA Binding
Metal Ion Binding
Protein Dimerization Activity
Translation Initiation Factor Activity
Protein Binding
Ribosome Binding
Poly(A) RNA Binding
Biological Process
Response To Stress
Signal Transduction
Negative Regulation Of Cell Proliferation
Translation
Translational Initiation
Activation Of Signaling Protein Activity Involved In Unfolded Protein Response
Gene Expression
Endoplasmic Reticulum Unfolded Protein Response
Regulation Of Translational Initiation In Response To Stress
Cellular Protein Metabolic Process
Protein Autophosphorylation
Pathways
Translation initiation complex formation
Recycling of eIF2:GDP
Translation
L13a-mediated translational silencing of Ceruloplasmin expression
Ribosomal scanning and start codon recognition
Formation of the ternary complex, and subsequently, the 43S complex
GTP hydrolysis and joining of the 60S ribosomal subunit
Eukaryotic Translation Initiation
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Cap-dependent Translation Initiation
PERK regulates gene expression
Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS
Protein-Protein Interactions
7 interactors:
DDX58
DNAJC3
EIF2AK2
EIF2S1
STK4
TACC1
TP53
19 interactors:
CASP3
CASP6
CSNK2A1
EIF1AX
EIF2AK1
EIF2AK2
EIF2AK3
EIF2B1
EIF2B2
EIF2B3
EIF2B4
EIF2S2
MELK
P4HB
PPP1R15A
PRKCD
PRKRIR
SFN
TERT
Entrez ID
5612
1965
HPRD ID
09567
04881
Ensembl ID
ENSG00000137492
ENSG00000134001
Uniprot IDs
O43422
P05198
Q53XC0
PDB IDs
1KL9
1Q8K
Enriched GO Terms of Interacting Partners
?
ER-nucleus Signaling Pathway
Response To Endoplasmic Reticulum Stress
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Phosphorylation
Positive Regulation Of Protein Modification Process
Endoplasmic Reticulum Unfolded Protein Response
Cellular Response To Unfolded Protein
Regulation Of Translational Initiation In Response To Stress
Cellular Response To Topologically Incorrect Protein
Regulation Of Protein Phosphorylation
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Kinase Activity
Response To Unfolded Protein
Positive Regulation Of Kinase Activity
Positive Regulation Of Protein Metabolic Process
Regulation Of Translation In Response To Stress
Regulation Of Phosphorylation
Positive Regulation Of Transferase Activity
Defense Response To Virus
Positive Regulation Of Cellular Metabolic Process
Regulation Of Phosphorus Metabolic Process
Protein Autophosphorylation
Regulation Of Protein Kinase Activity
Response To Biotic Stimulus
Regulation Of Kinase Activity
Response To Virus
Positive Regulation Of Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Activation Of Signaling Protein Activity Involved In Unfolded Protein Response
Positive Regulation Of Nuclease Activity
Immune System Process
Regulation Of Protein Metabolic Process
Regulation Of Catalytic Activity
Regulation Of Translational Initiation
Response To Organic Substance
Regulation Of Defense Response To Virus
Evasion Or Tolerance By Virus Of Host Immune Response
Viral Process
Regulation Of Apoptotic Process
Regulation Of Stem Cell Proliferation
Cellular Response To Stress
Positive Regulation Of Catalytic Activity
Regulation Of Cell Death
Negative Regulation Of Macromitophagy
Regulation Of Hematopoietic Stem Cell Differentiation
Oligodendrocyte Apoptotic Process
Signal Transduction
Negative Regulation Of Cell Proliferation
Negative Regulation Of Helicase Activity
RIG-I Signaling Pathway
Regulation Of Translational Initiation In Response To Stress
Regulation Of Translation In Response To Stress
Regulation Of Translational Initiation
Posttranscriptional Regulation Of Gene Expression
Negative Regulation Of Translational Initiation
Negative Regulation Of Translational Initiation In Response To Stress
Negative Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Protein Metabolic Process
Negative Regulation Of Translation In Response To Stress
Regulation Of Translation
Negative Regulation Of Translation
Cellular Response To Stress
Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation
Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of Protein Metabolic Process
Response To Stress
Translation
Translational Initiation
Oligodendrocyte Development
Intrinsic Apoptotic Signaling Pathway
Regulation Of Catalytic Activity
Apoptotic Process
Oligodendrocyte Differentiation
Protein Metabolic Process
Programmed Cell Death
Cellular Response To Stimulus
Positive Regulation Of Hydrolase Activity
Regulation Of Apoptotic Process
Cell Death
Death
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Positive Regulation Of Catalytic Activity
Regulation Of Cell Death
Glial Cell Development
Response To Heat
Cellular Protein Metabolic Process
Response To Glucose
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Apoptotic Signaling Pathway
Negative Regulation Of Cell Death
Response To Organic Substance
Response To Endoplasmic Reticulum Stress
Regulation Of Protein Phosphorylation
Response To Stimulus
Glial Cell Differentiation
Positive Regulation Of Metabolic Process
Response To Carbohydrate
Gene Expression
Tagcloud
?
atf4
atg7
cerebral
contributions
counteracted
deprivation
infarct
ischemia
ischemic
knocking
methyladenine
mitophagy
neuroprotection
occluded
ogd
park2
pba
protects
releasing
rep
reperfusion
rescue
sensor
tg
thapsigargin
tm
tmcao
transient
tunicamycin
Tagcloud (Difference)
?
atf4
atg7
cerebral
contributions
counteracted
deprivation
infarct
ischemia
ischemic
knocking
methyladenine
mitophagy
neuroprotection
occluded
ogd
park2
pba
protects
releasing
rep
reperfusion
rescue
sensor
tg
thapsigargin
tm
tmcao
transient
tunicamycin
Tagcloud (Intersection)
?