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PRKRIR and DNAJC3
Number of citations of the paper that reports this interaction (PMID
9447982
)
20
Data Source:
HPRD
(in vitro, two hybrid, in vivo)
PRKRIR
DNAJC3
Gene Name
protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
DnaJ (Hsp40) homolog, subfamily C, member 3
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Endoplasmic Reticulum Lumen
Smooth Endoplasmic Reticulum
Membrane
Endoplasmic Reticulum Sec Complex
Vesicle
Extracellular Vesicular Exosome
Molecular Function
DNA Binding
Metal Ion Binding
Protein Dimerization Activity
Protein Kinase Inhibitor Activity
Chaperone Binding
Misfolded Protein Binding
Biological Process
Response To Stress
Signal Transduction
Negative Regulation Of Cell Proliferation
Negative Regulation Of Protein Phosphorylation
Negative Regulation Of Protein Kinase Activity
Activation Of Signaling Protein Activity Involved In Unfolded Protein Response
Endoplasmic Reticulum Unfolded Protein Response
Negative Regulation Of Apoptotic Process
Cellular Protein Metabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Defense Response To Virus
Pathways
Influenza Viral RNA Transcription and Replication
IRE1alpha activates chaperones
Influenza Infection
Viral mRNA Translation
XBP1(S) activates chaperone genes
Unfolded Protein Response (UPR)
Influenza Life Cycle
Drugs
Diseases
GWAS
Protein-Protein Interactions
7 interactors:
DDX58
DNAJC3
EIF2AK2
EIF2S1
STK4
TACC1
TP53
6 interactors:
DNAJB1
EIF2AK2
EIF2AK3
HSPA1A
PRKRIR
TIRAP
Entrez ID
5612
5611
HPRD ID
09567
03114
Ensembl ID
ENSG00000137492
ENSG00000102580
Uniprot IDs
O43422
A8KA82
Q13217
PDB IDs
2Y4T
2Y4U
Enriched GO Terms of Interacting Partners
?
ER-nucleus Signaling Pathway
Response To Endoplasmic Reticulum Stress
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Phosphorylation
Positive Regulation Of Protein Modification Process
Endoplasmic Reticulum Unfolded Protein Response
Cellular Response To Unfolded Protein
Regulation Of Translational Initiation In Response To Stress
Cellular Response To Topologically Incorrect Protein
Regulation Of Protein Phosphorylation
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Kinase Activity
Response To Unfolded Protein
Positive Regulation Of Kinase Activity
Positive Regulation Of Protein Metabolic Process
Regulation Of Translation In Response To Stress
Regulation Of Phosphorylation
Positive Regulation Of Transferase Activity
Defense Response To Virus
Positive Regulation Of Cellular Metabolic Process
Regulation Of Phosphorus Metabolic Process
Protein Autophosphorylation
Regulation Of Protein Kinase Activity
Response To Biotic Stimulus
Regulation Of Kinase Activity
Response To Virus
Positive Regulation Of Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Activation Of Signaling Protein Activity Involved In Unfolded Protein Response
Positive Regulation Of Nuclease Activity
Immune System Process
Regulation Of Protein Metabolic Process
Regulation Of Catalytic Activity
Regulation Of Translational Initiation
Response To Organic Substance
Regulation Of Defense Response To Virus
Evasion Or Tolerance By Virus Of Host Immune Response
Viral Process
Regulation Of Apoptotic Process
Regulation Of Stem Cell Proliferation
Cellular Response To Stress
Positive Regulation Of Catalytic Activity
Regulation Of Cell Death
Negative Regulation Of Macromitophagy
Regulation Of Hematopoietic Stem Cell Differentiation
Oligodendrocyte Apoptotic Process
Signal Transduction
Negative Regulation Of Cell Proliferation
Negative Regulation Of Helicase Activity
RIG-I Signaling Pathway
Response To Unfolded Protein
Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation
Posttranscriptional Regulation Of Gene Expression
Negative Regulation Of Inclusion Body Assembly
Regulation Of Translational Initiation In Response To Stress
Regulation Of Translation In Response To Stress
Regulation Of Inclusion Body Assembly
Protein Refolding
Response To Stress
Response To Biotic Stimulus
Regulation Of Cellular Response To Heat
Positive Regulation Of Chemokine Production
Positive Regulation Of Cytokine Production
Response To Organic Substance
Regulation Of Chemokine Production
Cellular Response To Heat
Positive Regulation Of Protein Binding
Regulation Of Translational Initiation
Negative Regulation Of Translation
Regulation Of Cell Proliferation
Endoplasmic Reticulum Unfolded Protein Response
Regulation Of Cytokine Production
Cellular Response To Stress
Cellular Response To Unfolded Protein
Evasion Or Tolerance By Virus Of Host Immune Response
Positive Regulation Of Interleukin-15 Production
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production
TIRAP-dependent Toll-like Receptor 4 Signaling Pathway
Interaction With Host
ER-nucleus Signaling Pathway
Cellular Response To Topologically Incorrect Protein
Response To Heat
Positive Regulation Of Binding
Positive Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Cell Proliferation
Response To External Stimulus
Positive Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Cellular Response To Stimulus
Positive Regulation Of Toll-like Receptor 2 Signaling Pathway
Cellular Heat Acclimation
Regulation Of Hematopoietic Stem Cell Differentiation
Response To Other Organism
Regulation Of Protein Binding
Response To Endoplasmic Reticulum Stress
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Toll-like Receptor 3 Signaling Pathway
Evasion Or Tolerance Of Host Defenses By Virus
Negative Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Phosphorylation
Tagcloud
?
atf4
attenuation
bcl2
bip
chop
confirming
db
ddit3
ebp
homologue
hsp40
hspa5
immunoglobulin
interpretation
islet
islets
min6
oleate
overproduction
p58
palmitate
pancreas
secreting
sections
supply
triggers
virtually
xbp1
Tagcloud (Difference)
?
atf4
attenuation
bcl2
bip
chop
confirming
db
ddit3
ebp
homologue
hsp40
hspa5
immunoglobulin
interpretation
islet
islets
min6
oleate
overproduction
p58
palmitate
pancreas
secreting
sections
supply
triggers
virtually
xbp1
Tagcloud (Intersection)
?