THAP12 and DNAJC3

Number of citations of the paper that reports this interaction (PubMedID 9447982)
92

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		THAP12	DNAJC3
Description		THAP domain containing 12	DnaJ heat shock protein family (Hsp40) member C3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Extracellular Region Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Cytosol Membrane Azurophil Granule Lumen Extracellular Exosome Extracellular Vesicle
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Protein Dimerization Activity	Protein Kinase Inhibitor Activity Protein Kinase Binding Protein-folding Chaperone Binding Misfolded Protein Binding
	Biological Process	Signal Transduction Negative Regulation Of Cell Population Proliferation	Regulation Of Translation Response To Unfolded Protein Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Positive Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Negative Regulation Of Apoptotic Process Proteolysis Involved In Protein Catabolic Process Defense Response To Virus Cellular Response To Cold Negative Regulation Of Translation In Response To Endoplasmic Reticulum Stress Negative Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation
Pathways			Viral mRNA Translation XBP1(S) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation PKR-mediated signaling
Drugs
Diseases
GWAS		Asthma ( 31959851) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189)	Body mass index ( 28552196)
Interacting Genes		10 interacting genes: DNAJC3 EIF2AK2 EIF2S1 KIAA1958 MAPKAPK3 RIGI STK4 TACC1 TP53 ZNF526	8 interacting genes: DNAJB1 EIF2AK2 EIF2AK3 HSPA1A OGT THAP12 TIRAP UBC
Entrez ID		5612	5611
HPRD ID		09567	03114
Ensembl ID		ENSG00000137492	ENSG00000102580
Uniprot IDs		A0A140VJQ7 O43422	A8KA82 Q13217
PDB IDs			2Y4T 2Y4U
Enriched GO Terms of Interacting Partners?		Regulation Of Translation In Response To Endoplasmic Reticulum Stress Response To Endoplasmic Reticulum Stress Regulation Of Translational Initiation In Response To Stress Regulation Of Translational Initiation Positive Regulation Of Epithelial Cell Apoptotic Process Regulation Of Translation In Response To Stress Regulation Of Protein Metabolic Process Cellular Response To Starvation Negative Regulation Of Translation Intracellular Signal Transduction ER-nucleus Signaling Pathway Response To Starvation Negative Regulation Of Protein Metabolic Process Mitophagy Cellular Response To Amino Acid Starvation Regulation Of Epithelial Cell Apoptotic Process Translation Initiation Ternary Complex Cellular Response To Nutrient Levels Defense Response To Virus Positive Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Negative Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Positive Regulation Of Hepatocyte Apoptotic Process Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition MRNA Transcription Response To Amino Acid Starvation Endoplasmic Reticulum Unfolded Protein Response Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Autophagy Of Mitochondrion Double-stranded RNA Binding Translational Initiation Antiviral Innate Immune Response Protein Serine Kinase Activity Response To Manganese-induced Endoplasmic Reticulum Stress Glial Limiting End-foot Cellular Response To UV Cellular Response To Light Stimulus Regulation Of Translation Response To Virus Regulation Of Stem Cell Proliferation Protein Serine/threonine Kinase Activity Positive Regulation Of Translational Initiation In Response To Stress Protein-folding Chaperone Binding Negative Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Protein Tetramerization Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia	Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Inclusion Body Assembly Response To Unfolded Protein Regulation Of Translational Initiation Misfolded Protein Binding Regulation Of Protein-containing Complex Assembly Regulation Of Inclusion Body Assembly Response To Temperature Stimulus Positive Regulation Of Cytokine Production Regulation Of Cellular Response To Stress Negative Regulation Of Translation Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Gene Expression Response To Stress Negative Regulation Of Protein Metabolic Process Post-transcriptional Regulation Of Gene Expression Response To Endoplasmic Reticulum Stress Transcription Regulator Inhibitor Activity Cellular Response To Nutrient Levels Negative Regulation Of Translational Initiation Cellular Response To Heat Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Protein Folding Chaperone Positive Regulation Of Interleukin-8 Production Regulation Of Cytokine Production Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Interleukin-15 Production Cellular Response To Stress Negative Regulation Of Macromolecule Metabolic Process Cytosol Positive Regulation Of Chemokine Production Negative Regulation Of Protein Ubiquitination Positive Regulation Of NF-kappaB Transcription Factor Activity Translational Initiation Positive Regulation Of Multicellular Organismal Process Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Response To Heat Regulation Of Interleukin-8 Production Negative Regulation Of Metabolic Process Negative Regulation Of Post-translational Protein Modification Regulation Of Response To Endoplasmic Reticulum Stress Denatured Protein Binding Regulation Of Translation Regulation Of Chemokine Production Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
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