DHX58 and NKRF

Number of citations of the paper that reports this interaction (PubMedID 21903422)
55

Data Source:
BioGRID (pull down)

		DHX58	NKRF
Description		DExH-box helicase 58	NFKB repressing factor
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GO Annotations	Cellular Component	Cytoplasm	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Nucleotide Binding DNA Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding Single-stranded RNA Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific ATPase Activator Activity Nucleic Acid Binding DNA Binding RNA Binding Protein Binding
	Biological Process	Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Response To Virus Response To Bacterium Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Negative Regulation Of MDA-5 Signaling Pathway Negative Regulation Of RIG-I Signaling Pathway Innate Immune Response Regulation Of Innate Immune Response Negative Regulation Of Innate Immune Response Defense Response To Virus Antiviral Innate Immune Response Positive Regulation Of MDA-5 Signaling Pathway Positive Regulation Of RIG-I Signaling Pathway	Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		DDX58/IFIH1-mediated induction of interferon-alpha/beta
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Fasting plasma glucose ( 31932636) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		10 interacting genes: AGO2 AP2B1 APP DHX30 DICER1 EIF2AK2 EIF6 NKRF STAU2 TRIM14	16 interacting genes: ADARB1 DHX15 DHX58 FILNC1 HMOX2 KIFC1 NFKB1 NFKB2 PRKN PRKRA REL RELA STAU1 TARBP2 USP7 ZNF346
Entrez ID		79132	55922
HPRD ID		13115	02341
Ensembl ID		ENSG00000108771	ENSG00000186416
Uniprot IDs		A0AA51U9C6 Q96C10	A0AAG2UWQ9 A3F769 O15226
PDB IDs		2RQA 2W4R 3EQT	6SH6 6SH7
Enriched GO Terms of Interacting Partners?		Double-stranded RNA Binding RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism Protein-RNA Complex Assembly RISC-loading Complex SiRNA Processing Post-transcriptional Regulation Of Gene Expression Translational Initiation RISC Complex Assembly SiRNA Binding Protein-containing Complex Assembly Pre-miRNA Processing Protein-containing Complex Organization Post-transcriptional Gene Silencing Regulation Of Translation RNA Binding MiRNA Metabolic Process Regulatory NcRNA-mediated Gene Silencing Negative Regulation Of Translation MiRNA Processing RNA Endonuclease Activity Nucleic Acid Binding Negative Regulation Of Gene Expression Dendritic Shaft Postsynapse Translation Initiation Factor Activity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Synapse Organization Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Assembly Of Large Subunit Precursor Of Preribosome Regulatory RNA Binding Endoribonuclease Activity, Cleaving SiRNA-paired MRNA Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Carbohydrate Catabolic Process Negative Regulation Of Biosynthetic Process Clathrin-coated Pit Positive Regulation Of Chemokine Production Regulation Of ATP Metabolic Process Ribosome Binding Negative Regulation Of Viral Process Endonuclease Activity Nucleus Translation Cellular Component Assembly Axo-dendritic Transport	Double-stranded RNA Binding Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Gene Expression Canonical NF-kappaB Signal Transduction Innate Immune Response Response To Virus Antiviral Innate Immune Response NF-kappaB P50/p65 Complex Defense Response To Symbiont Defense Response To Other Organism Positive Regulation Of Viral Genome Replication I-kappaB/NF-kappaB Complex Immune Response Defense Response To Virus NF-kappaB Complex Response To External Biotic Stimulus Immune System Process Response To Stress Response To Oxidative Stress Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Nicotine Enzyme Binding RISC-loading Complex SiRNA Processing Positive Regulation Of Viral Process Pre-miRNA Binding Response To Other Organism Negative Regulation Of Metabolic Process Cellular Response To Oxidative Stress RISC Complex Assembly Negative Regulation Of Macromolecule Biosynthetic Process SiRNA Binding Regulation Of Viral Genome Replication Negative Regulation Of Kinase Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Biosynthetic Process Actinin Binding Pre-miRNA Processing Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Regulatory NcRNA Processing Cellular Response To Angiotensin Cellular Response To Interleukin-6 Cellular Response To Chemical Stress Cytoplasmic Pattern Recognition Receptor Signaling Pathway Defense Response Regulation Of Viral Life Cycle Response To Interleukin-6 Negative Regulation Of Phosphorylation
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