DHX58 and AP2B1

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DHX58	AP2B1
Description		DExH-box helicase 58	adaptor related protein complex 2 subunit beta 1
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GO Annotations	Cellular Component	Cytoplasm	Lysosomal Membrane Cytosol Plasma Membrane Clathrin-coated Pit Synaptic Vesicle Cytoplasmic Side Of Plasma Membrane Endomembrane System Membrane Membrane Coat Clathrin Coat AP-2 Adaptor Complex Clathrin Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Endolysosome Membrane Synapse Clathrin-coated Endocytic Vesicle Postsynaptic Endocytic Zone Extrinsic Component Of Presynaptic Endocytic Zone Membrane Glutamatergic Synapse
	Molecular Function	Nucleotide Binding DNA Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding Single-stranded RNA Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Metal Ion Binding	Signal Sequence Binding Protein Binding Clathrin Binding Clathrin Adaptor Activity Protein-containing Complex Binding
	Biological Process	Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Response To Virus Response To Bacterium Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Negative Regulation Of MDA-5 Signaling Pathway Negative Regulation Of RIG-I Signaling Pathway Innate Immune Response Regulation Of Innate Immune Response Negative Regulation Of Innate Immune Response Defense Response To Virus Antiviral Innate Immune Response Positive Regulation Of MDA-5 Signaling Pathway Positive Regulation Of RIG-I Signaling Pathway	Kidney Development Cardiac Septum Development Ventricular Septum Development Intracellular Protein Transport Endocytosis Chemical Synaptic Transmission Neurotransmitter Secretion Heart Development Protein Transport Vesicle-mediated Transport Aorta Development Positive Regulation Of Endocytosis Clathrin Coat Assembly Synaptic Vesicle Endocytosis Coronary Vasculature Development Clathrin-dependent Endocytosis Postsynaptic Neurotransmitter Receptor Internalization Positive Regulation Of Protein Localization To Membrane
Pathways		DDX58/IFIH1-mediated induction of interferon-alpha/beta	Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Fasting plasma glucose ( 31932636) Mean spheric corpuscular volume ( 32888494)	Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 22139419 27863252 32888494) Mean reticulocyte volume ( 32888494) Platelet count ( 22139419 27863252) Platelet distribution width ( 27863252) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)
Interacting Genes		10 interacting genes: AGO2 AP2B1 APP DHX30 DICER1 EIF2AK2 EIF6 NKRF STAU2 TRIM14	60 interacting genes: - ACVR1 AFF4 AP1M1 AP1M2 AP2A2 AP2M1 AP2S1 APC ARF6 ARRB1 ATM ATP23 ATP6V1G1 BUB1 BUB1B CATSPERT CCDC187 CEBPA CLINT1 COL3A1 DHX58 DNAJC5 DSCAM FMNL2 GPANK1 GTF2I HIP1 HPCA HSPB1 KANK2 KIAA0408 KPNA2 LDLRAP1 LONRF1 MEA1 MLH1 NECAP2 NEU4 NUP54 PIP5K1C POM121 PSORS1C2 RAPGEF3 RIBC2 SLC25A6 SLC2A8 SMAD4 SMURF1 SNAP91 TENT5C TERF2IP TEX12 TGFBR1 TGFBR2 THAP1 TUBGCP4 TXN2 U2AF1 UBC
Entrez ID		79132	163
HPRD ID		13115	03015
Ensembl ID		ENSG00000108771	ENSG00000006125
Uniprot IDs		A0AA51U9C6 Q96C10	A0A140VJE8 P63010 Q96EL6
PDB IDs		2RQA 2W4R 3EQT	1E42 2G30 2IV8 2IV9 2JKR 2JKT 2VGL 2XA7 4UQI 5M5R 6QH5 6QH6 6QH7 6URI 6YAE 6YAF 6YAH 6YAI 7OG1 7OHO 7OM8 7Z5C
Enriched GO Terms of Interacting Partners?		Double-stranded RNA Binding RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism Protein-RNA Complex Assembly RISC-loading Complex SiRNA Processing Post-transcriptional Regulation Of Gene Expression Translational Initiation RISC Complex Assembly SiRNA Binding Protein-containing Complex Assembly Pre-miRNA Processing Protein-containing Complex Organization Post-transcriptional Gene Silencing Regulation Of Translation RNA Binding MiRNA Metabolic Process Regulatory NcRNA-mediated Gene Silencing Negative Regulation Of Translation MiRNA Processing RNA Endonuclease Activity Nucleic Acid Binding Negative Regulation Of Gene Expression Dendritic Shaft Postsynapse Translation Initiation Factor Activity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Synapse Organization Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Assembly Of Large Subunit Precursor Of Preribosome Regulatory RNA Binding Endoribonuclease Activity, Cleaving SiRNA-paired MRNA Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Carbohydrate Catabolic Process Negative Regulation Of Biosynthetic Process Clathrin-coated Pit Positive Regulation Of Chemokine Production Regulation Of ATP Metabolic Process Ribosome Binding Negative Regulation Of Viral Process Endonuclease Activity Nucleus Translation Cellular Component Assembly Axo-dendritic Transport	Clathrin Adaptor Activity SMAD Binding Clathrin Adaptor Complex Clathrin-dependent Endocytosis Clathrin-coated Pit Synaptic Vesicle Endocytosis Regulation Of Receptor-mediated Endocytosis Presynaptic Endocytosis Endocytosis Clathrin Coat Assembly Vesicle-mediated Transport In Synapse Activin Receptor Complex Activin Receptor Activity, Type I Postsynaptic Neurotransmitter Receptor Internalization Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Activin Receptor Signaling Pathway Receptor-mediated Endocytosis Mitotic Spindle Assembly Checkpoint Signaling Intracellular Protein Transport Clathrin-coated Endocytic Vesicle Membrane Negative Regulation Of Mitotic Metaphase/anaphase Transition Activin Binding Endocytic Vesicle Membrane AP-2 Adaptor Complex Receptor Internalization Clathrin-coated Vesicle Membrane Clathrin Binding Protein Transport Transmembrane Receptor Protein Serine/threonine Kinase Activity Clathrin-coated Vesicle Negative Regulation Of Chromosome Organization Ventricular Septum Morphogenesis Negative Regulation Of Mitotic Nuclear Division Positive Regulation Of SMAD Protein Signal Transduction Import Into Cell Regulation Of Endocytosis Vesicle-mediated Transport I-SMAD Binding Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA-dependent Protein Kinase Activity Transforming Growth Factor Beta Ligand-receptor Complex Transforming Growth Factor Beta Receptor Signaling Pathway Endolysosome Membrane Positive Regulation Of Receptor-mediated Endocytosis Transforming Growth Factor Beta Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Cellular Component Organization Establishment Of Protein Localization Positive Regulation Of Cellular Component Organization Intracellular Protein Localization
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