DHX58

Description		DExH-box helicase 58
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GO Annotations	Cellular Component	Cytoplasm
	Molecular Function	Nucleotide Binding DNA Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding Single-stranded RNA Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Metal Ion Binding
	Biological Process	Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Response To Virus Response To Bacterium Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Negative Regulation Of MDA-5 Signaling Pathway Negative Regulation Of RIG-I Signaling Pathway Innate Immune Response Regulation Of Innate Immune Response Negative Regulation Of Innate Immune Response Defense Response To Virus Antiviral Innate Immune Response Positive Regulation Of MDA-5 Signaling Pathway Positive Regulation Of RIG-I Signaling Pathway
Pathways		DDX58/IFIH1-mediated induction of interferon-alpha/beta
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Fasting plasma glucose ( 31932636) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		10 interacting genes: AGO2 AP2B1 APP DHX30 DICER1 EIF2AK2 EIF6 NKRF STAU2 TRIM14
Entrez ID		79132
HPRD ID		13115
Ensembl ID		ENSG00000108771
Uniprot IDs		A0AA51U9C6 Q96C10
PDB IDs		2RQA 2W4R 3EQT
Enriched GO Terms of Interacting Partners?		Double-stranded RNA Binding RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism Protein-RNA Complex Assembly RISC-loading Complex SiRNA Processing Post-transcriptional Regulation Of Gene Expression Translational Initiation RISC Complex Assembly SiRNA Binding Protein-containing Complex Assembly Pre-miRNA Processing Protein-containing Complex Organization Post-transcriptional Gene Silencing Regulation Of Translation RNA Binding MiRNA Metabolic Process Regulatory NcRNA-mediated Gene Silencing Negative Regulation Of Translation MiRNA Processing RNA Endonuclease Activity Nucleic Acid Binding Negative Regulation Of Gene Expression Dendritic Shaft Postsynapse Translation Initiation Factor Activity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Synapse Organization Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Assembly Of Large Subunit Precursor Of Preribosome Regulatory RNA Binding Endoribonuclease Activity, Cleaving SiRNA-paired MRNA Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Carbohydrate Catabolic Process Negative Regulation Of Biosynthetic Process Clathrin-coated Pit Positive Regulation Of Chemokine Production Regulation Of ATP Metabolic Process Ribosome Binding Negative Regulation Of Viral Process Endonuclease Activity Nucleus Translation Cellular Component Assembly Axo-dendritic Transport
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