NR2E1

Description		nuclear receptor subfamily 2 group E member 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Enzyme Binding Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Behavioral Fear Response Positive Regulation Of Neuroblast Proliferation Aggressive Behavior Regulation Of DNA-templated Transcription Apoptotic Process Nervous System Development Neuroblast Proliferation Brain Development Visual Perception Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Dentate Gyrus Development Amygdala Development Olfactory Bulb Development Layer Formation In Cerebral Cortex Forebrain Generation Of Neurons Cerebral Cortex Neuron Differentiation Central Nervous System Neuron Differentiation Anterior Commissure Morphogenesis Cerebral Cortex Development Cell Differentiation Extracellular Matrix Organization Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Intracellular Receptor Signaling Pathway Somatic Stem Cell Population Maintenance Social Behavior Camera-type Eye Development Negative Regulation Of Apoptotic Process Astrocyte Cell Migration Cell Fate Commitment Negative Regulation Of Neuron Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Astrocyte Differentiation Negative Regulation Of Astrocyte Differentiation Regulation Of Dendrite Morphogenesis Regulation Of Cellular Component Organization Retina Development In Camera-type Eye Regulation Of Timing Of Neuron Differentiation Long-term Synaptic Potentiation Neural Precursor Cell Proliferation Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Stem Cell Proliferation
Pathways		Nuclear Receptor transcription pathway Regulation of PTEN gene transcription
Drugs
Diseases
GWAS
Novel Interacting Genes		1 novel interacting genes: RAB27B
Interacting Genes		6 interacting genes: ATN1 DNMT3L ERBIN KDM1A NSD1 RERE
Entrez ID		7101
HPRD ID		07230
Ensembl ID		ENSG00000112333
Uniprot IDs		B6ZGT9 Q9Y466
PDB IDs		4XAJ
Enriched GO Terms of Interacting Partners?		Transcription Corepressor Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Nuclear Androgen Receptor Binding Regulation Of Chromatin Organization Chromatin Remodeling Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Transcription Coactivator Activity Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Post-embryonic Development Regulation Of Nucleobase-containing Compound Metabolic Process Cerebellar Purkinje Cell Layer Maturation Chromatin Binding Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Basal Protein Localization Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Radial Glia Guided Migration Of Purkinje Cell Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Epigenetic Programing Of Female Pronucleus ErbB-2 Class Receptor Binding Positive Regulation Of Biosynthetic Process Protein Demethylase Activity Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Histone H3K36 Dimethyltransferase Activity Establishment Or Maintenance Of Cell Polarity Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Branching Morphogenesis Of A Nerve Platelet Dense Granule Membrane Response To Fungicide MRF Binding Guanine Metabolic Process Chorionic Trophoblast Cell Differentiation Autosome Genomic Imprinting Negative Regulation Of Heterochromatin Formation Negative Regulation Of Monocyte Chemotactic Protein-1 Production Regulation Of Macromolecule Biosynthetic Process Methylation
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