VPS11 and WNT1

		VPS11	WNT1
Description		VPS11 core subunit of CORVET and HOPS complexes	Wnt family member 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Autophagosome Endosome Membrane Membrane Clathrin-coated Vesicle Endocytic Vesicle HOPS Complex Cytoplasmic Vesicle Late Endosome Membrane CORVET Complex Vesicle Tethering Complex	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Endocytic Vesicle Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Syntaxin Binding Protein-macromolecule Adaptor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Signaling Receptor Binding Frizzled Binding Cytokine Activity Morphogen Activity Protein Domain Specific Binding Receptor Ligand Activity
	Biological Process	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Autophagy Endosome Organization Vacuole Organization Endosome To Lysosome Transport Protein Transport Vesicle-mediated Transport Protein Ubiquitination Regulation Of Protein Stability Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly Positive Regulation Of Protein Catabolic Process Organelle Fusion Regulation Of Organelle Assembly Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Early Endosome To Late Endosome Transport	Embryonic Axis Specification Branching Involved In Ureteric Bud Morphogenesis Cell-cell Signaling Myoblast Fusion Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Response To Wounding Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Cell-substrate Adhesion Myotube Differentiation Wnt Signaling Pathway Spinal Cord Association Neuron Differentiation Diencephalon Development Cerebellum Development Central Nervous System Morphogenesis Cerebellum Formation Forebrain Anterior/posterior Pattern Specification Midbrain-hindbrain Boundary Maturation During Brain Development Neurogenesis Metencephalon Development Negative Regulation Of Cell-cell Adhesion Neuron Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Midbrain Development Midbrain-hindbrain Boundary Development Animal Organ Regeneration T Cell Differentiation In Thymus Cell Proliferation In Midbrain Astrocyte-dopaminergic Neuron Signaling Inner Ear Morphogenesis Signal Transduction In Response To DNA Damage Negative Regulation Of Apoptotic Process Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cell Fate Commitment Fat Cell Differentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation Neuron Fate Commitment Neuron Fate Determination Spemann Organizer Formation Canonical Wnt Signaling Pathway Bone Development Positive Regulation Of Dermatome Development Hepatocyte Differentiation Cellular Response To Peptide Hormone Stimulus Hematopoietic Stem Cell Proliferation Dopaminergic Neuron Differentiation Positive Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Midbrain Dopaminergic Neuron Differentiation Embryonic Brain Development Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Senescence
Pathways		SARS-CoV-2 modulates autophagy	TCF dependent signaling in response to WNT TCF dependent signaling in response to WNT WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors) Transcriptional regulation of white adipocyte differentiation PCP/CE pathway PCP/CE pathway Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 29273807) Coronary artery disease ( 29212778 33020668) HDL cholesterol levels ( 32203549) Plateletcrit ( 32888494)	Bipolar disorder ( 31043756) Heel bone mineral density ( 28869591 30598549)
Interacting Genes		33 interacting genes: BCAR1 BMI1 ECPAS EZR GGA3 GRSF1 KDM1A KRTAP10-3 KRTAP10-8 LRSAM1 LSM1 MARK3 MON1B MSN RAB7A RDX RILP RNF181 STX1A STX6 STX7 STX8 TFAP2B TRIM32 TSG101 UBE2D2 UBE2L3 UBE2U UVRAG VPS16 VPS18 VPS33A VPS45	9 interacting genes: FZD8 FZD9 LRP5 LRP6 PORCN RYK SFRP1 SFRP2 WNT3A
Entrez ID		55823	7471
HPRD ID		12258	01276
Ensembl ID		ENSG00000160695	ENSG00000125084
Uniprot IDs		A0A087WXL6 B7Z879 Q9H270	P04628
PDB IDs
Enriched GO Terms of Interacting Partners?		Late Endosome Membrane Docking Vesicle Organization Organelle Membrane Fusion Vesicle Fusion Organelle Fusion Endosome Vesicle-mediated Transport Intracellular Protein Transport Membrane Fusion Early Endosome Vacuolar Transport Endosome To Lysosome Transport Intracellular Protein Localization Lysosomal Transport Positive Regulation Of Catabolic Process Establishment Of Protein Localization Protein Transport Organelle Localization Macromolecule Catabolic Process Catabolic Process Vesicle Docking SNARE Binding Regulation Of Protein Localization Positive Regulation Of Protein Catabolic Process Cellular Localization Chloride Channel Inhibitor Activity CORVET Complex Clathrin-coated Vesicle Intracellular Transport Organelle Localization By Membrane Tethering Positive Regulation Of Early Endosome To Late Endosome Transport Autophagosome Membrane Organization Endosome Organization Late Endosome Membrane Positive Regulation Of Protein Localization To Early Endosome SNAP Receptor Activity Endosomal Transport Positive Regulation Of Protein Localization To Endosome Establishment Of Localization In Cell Endosome Membrane SNARE Complex HOPS Complex Autophagy Autophagosome Maturation Syntaxin Binding Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Positive Regulation Of Protein Metabolic Process	Wnt-protein Binding Canonical Wnt Signaling Pathway Wnt Signaling Pathway Wnt-Frizzled-LRP5/6 Complex Wnt Receptor Activity Non-canonical Wnt Signaling Pathway Frizzled Binding Dopaminergic Neuron Differentiation Regulation Of Dopaminergic Neuron Differentiation Cell Surface Receptor Signaling Pathway Midbrain Dopaminergic Neuron Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway Neuron Differentiation Regulation Of Fat Cell Differentiation Wnt Signaling Pathway Involved In Somitogenesis Regulation Of Midbrain Dopaminergic Neuron Differentiation Positive Regulation Of Wnt Signaling Pathway Anterior/posterior Pattern Specification Negative Regulation Of Cell Growth Somitogenesis Development Of Primary Male Sexual Characteristics Positive Regulation Of Neural Precursor Cell Proliferation Segmentation Positive Regulation Of Cell Population Proliferation Coreceptor Activity Convergent Extension Involved In Axis Elongation Negative Regulation Of Growth Toxin Transmembrane Transporter Activity Regulation Of Establishment Of Planar Polarity Positive Regulation Of Fat Cell Differentiation Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Axon Extension Involved In Axon Guidance Development Of Primary Sexual Characteristics Regulation Of Mesodermal Cell Differentiation Regionalization Regulation Of Animal Organ Morphogenesis Cellular Response To X-ray Tube Morphogenesis Regulation Of Neural Precursor Cell Proliferation Cellular Developmental Process Negative Regulation Of Cell Differentiation Wnt Signalosome Regulation Of Wnt Signaling Pathway Convergent Extension Morphogenesis Of An Epithelium Tissue Development Signal Transduction Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Locomotion Anatomical Structure Formation Involved In Morphogenesis
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