WNT1 and SFRP1

Number of citations of the paper that reports this interaction (PMID 10347172)
54

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		WNT1	SFRP1
Gene Name		wingless-type MMTV integration site family, member 1	secreted frizzled-related protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Intracellular Cytosol Plasma Membrane Cell Surface Integral Component Of Membrane Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Frizzled Binding Cytokine Activity Protein Domain Specific Binding Transcription Regulatory Region DNA Binding Receptor Agonist Activity	Cysteine-type Endopeptidase Activity G-protein Coupled Receptor Activity Frizzled Binding Protein Binding Drug Binding Heparin Binding Wnt-protein Binding Identical Protein Binding Wnt-activated Receptor Activity
	Biological Process	Embryonic Axis Specification Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Protein Phosphorylation Cell-cell Signaling Myoblast Fusion Positive Regulation Of Cell Proliferation Response To Wounding Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Cell-substrate Adhesion Wnt Signaling Pathway Spinal Cord Association Neuron Differentiation Diencephalon Development Central Nervous System Morphogenesis Cerebellum Formation Forebrain Anterior/posterior Pattern Specification Midbrain-hindbrain Boundary Maturation During Brain Development Negative Regulation Of Cell-cell Adhesion Neuron Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Midbrain Development Organ Regeneration T Cell Differentiation In Thymus Inner Ear Morphogenesis Signal Transduction In Response To DNA Damage Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Cell Fate Commitment Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fibroblast Proliferation Neuron Fate Determination Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Spemann Organizer Formation Canonical Wnt Signaling Pathway Bone Development Positive Regulation Of Dermatome Development Hepatocyte Differentiation Cellular Response To Peptide Hormone Stimulus Hematopoietic Stem Cell Proliferation Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cell Aging Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Osteoblast Differentiation Ureteric Bud Development Neural Tube Closure Positive Regulation Of Cell-matrix Adhesion Hematopoietic Progenitor Cell Differentiation Proteolysis Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Male Gonad Development Female Gonad Development Cellular Response To Starvation Dorsal/ventral Axis Specification Regulation Of Cell Cycle Process Negative Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Neural Crest Cell Fate Commitment Response To Organic Cyclic Compound Menstrual Cycle Phase Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Ossification Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Rac GTPase Activity Negative Regulation Of Osteoblast Proliferation Somatic Stem Cell Maintenance Response To Drug Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity Cellular Response To Fibroblast Growth Factor Stimulus Stromal-epithelial Cell Signaling Involved In Prostate Gland Development Negative Regulation Of B Cell Differentiation Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Osteoclast Differentiation Regulation Of Angiogenesis Positive Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Insulin Secretion Negative Regulation Of Bone Remodeling Negative Regulation Of Fibroblast Proliferation Digestive Tract Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Canonical Wnt Signaling Pathway Hematopoietic Stem Cell Differentiation Bone Trabecula Formation Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Regulation Of Branching Involved In Prostate Gland Morphogenesis Negative Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Vitamin D Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Cellular Response To Prostaglandin E Stimulus Cellular Response To Estrogen Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Hypoxia Cellular Response To X-ray Cellular Response To Heparin Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To BMP Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Planar Cell Polarity Pathway Involved In Neural Tube Closure Wnt Signaling Pathway Involved In Somitogenesis Convergent Extension Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Planar Cell Polarity Pathway Involved In Axis Elongation Positive Regulation Of Non-canonical Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Negative Regulation Of Canonical Wnt Signaling Pathway Involved In Controlling Type B Pancreatic Cell Proliferation Negative Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Fibroblast Apoptotic Process
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes WNT ligand biogenesis and trafficking beta-catenin independent WNT signaling disassembly of the destruction complex and recruitment of AXIN to the membrane WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Transcriptional regulation of white adipocyte differentiation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Class B/2 (Secretin family receptors) PCP/CE pathway	misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation negative regulation of TCF-dependent signaling by WNT ligand antagonists XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: FZD8 FZD9 LRP5 LRP6 PORCN RYK SFRP1 SFRP2 WNT3A	6 interactors: FZD6 KIAA1522 PPP1CA WNT1 WNT2 WNT4
Entrez ID		7471	6422
HPRD ID		01276	09165
Ensembl ID			ENSG00000104332
Uniprot IDs		P04628	Q6ZSL4 Q8N474
PDB IDs
Enriched GO Terms of Interacting Partners?		Wnt Signaling Pathway Canonical Wnt Signaling Pathway Axis Elongation Involved In Somitogenesis Non-canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Axis Elongation Regulation Of Fat Cell Differentiation Wnt Signaling Pathway Involved In Somitogenesis Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Cell Surface Receptor Signaling Pathway Convergent Extension Anterior/posterior Pattern Specification Somitogenesis Stem Cell Proliferation Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Somite Development Regulation Of Wnt Signaling Pathway Positive Regulation Of Signal Transduction Post-anal Tail Morphogenesis Regulation Of Phosphorylation Immune System Development Regulation Of Embryonic Development Segmentation Regulation Of Protein Kinase Activity Dorsal/ventral Axis Specification Dorsal/ventral Pattern Formation Regulation Of Kinase Activity Wnt Signaling Pathway Involved In Forebrain Neuroblast Division Regulation Of Phosphorus Metabolic Process Epithelial Tube Morphogenesis Negative Regulation Of Protein Serine/threonine Kinase Activity Developmental Growth Involved In Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Stem Cell Differentiation Tube Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Axis Elongation Pattern Specification Process Regulation Of Organ Morphogenesis Regulation Of Bone Remodeling Morphogenesis Of An Epithelium Negative Regulation Of Wnt Signaling Pathway Neural Tube Development Organ Development Anatomical Structure Formation Involved In Morphogenesis Regulation Of Ossification Regulation Of Protein Phosphorylation Mesenchyme Development Neural Crest Formation	Tissue Morphogenesis Positive Regulation Of Embryonic Development Tube Development Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Receptor Activity Wnt Signaling Pathway Positive Regulation Of Dermatome Development Developmental Induction Regulation Of Wnt Signaling Pathway Epithelium Development Epithelial Tube Morphogenesis Tube Morphogenesis Canonical Wnt Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Morphogenesis Of An Epithelium Regulation Of Embryonic Development Regulation Of Receptor Activity Positive Regulation Of Canonical Wnt Signaling Pathway Tissue Development Positive Regulation Of Wnt Signaling Pathway Regulation Of Organ Morphogenesis Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Branching Morphogenesis Of An Epithelial Tube Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Anatomical Structure Morphogenesis Organ Morphogenesis Non-canonical Wnt Signaling Pathway Cell Fate Commitment Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Embryo Development Negative Regulation Of Signaling Organ Development Positive Regulation Of Signal Transduction Regulation Of Signaling Cell Surface Receptor Signaling Pathway Epithelial To Mesenchymal Transition Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Fibroblast Proliferation T Cell Differentiation In Thymus Embryonic Organ Development Ureteric Bud Morphogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Gland Development Muscle Structure Development Nephron Morphogenesis
Tagcloud ?		access acid breaks chromosome cloning embryonic experiments inducible karyotypes late lines morphologies morphology neurogenesis observing p19 placed produced responsive resulting retinoic see sequences transcribed undifferentiated useful variety wide would	aberrant ag alterations array basel bead bench breast cancers cdh1 dkk3 epigenetic inactivated karger methylation neoadjuvant next notch notch1 notch2 paxgene pik3ca potentially probes processed sequencer solved statuses top
Tagcloud (Difference) ?		access acid breaks chromosome cloning embryonic experiments inducible karyotypes late lines morphologies morphology neurogenesis observing p19 placed produced responsive resulting retinoic see sequences transcribed undifferentiated useful variety wide would	aberrant ag alterations array basel bead bench breast cancers cdh1 dkk3 epigenetic inactivated karger methylation neoadjuvant next notch notch1 notch2 paxgene pik3ca potentially probes processed sequencer solved statuses top
Tagcloud (Intersection) ?