WNT1 and SFRP1

Number of citations of the paper that reports this interaction (PubMedID 10347172)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		WNT1	SFRP1
Description		Wnt family member 1	secreted frizzled related protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Endocytic Vesicle Membrane Extracellular Exosome	Extracellular Region Extracellular Space Cytosol Plasma Membrane Cell Surface Extracellular Matrix Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Frizzled Binding Cytokine Activity Morphogen Activity Protein Domain Specific Binding Receptor Ligand Activity	Cysteine-type Endopeptidase Activity Frizzled Binding Protein Binding Heparin Binding Wnt-protein Binding Identical Protein Binding
	Biological Process	Embryonic Axis Specification Branching Involved In Ureteric Bud Morphogenesis Cell-cell Signaling Myoblast Fusion Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Response To Wounding Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Cell-substrate Adhesion Myotube Differentiation Wnt Signaling Pathway Spinal Cord Association Neuron Differentiation Diencephalon Development Cerebellum Development Central Nervous System Morphogenesis Cerebellum Formation Forebrain Anterior/posterior Pattern Specification Midbrain-hindbrain Boundary Maturation During Brain Development Neurogenesis Metencephalon Development Negative Regulation Of Cell-cell Adhesion Neuron Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Midbrain Development Midbrain-hindbrain Boundary Development Animal Organ Regeneration T Cell Differentiation In Thymus Cell Proliferation In Midbrain Astrocyte-dopaminergic Neuron Signaling Inner Ear Morphogenesis Signal Transduction In Response To DNA Damage Negative Regulation Of Apoptotic Process Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cell Fate Commitment Fat Cell Differentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation Neuron Fate Commitment Neuron Fate Determination Spemann Organizer Formation Canonical Wnt Signaling Pathway Bone Development Positive Regulation Of Dermatome Development Hepatocyte Differentiation Cellular Response To Peptide Hormone Stimulus Hematopoietic Stem Cell Proliferation Dopaminergic Neuron Differentiation Positive Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Midbrain Dopaminergic Neuron Differentiation Embryonic Brain Development Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Senescence	Osteoblast Differentiation Ureteric Bud Development Somitogenesis Neural Tube Closure Positive Regulation Of Cell-matrix Adhesion Hematopoietic Progenitor Cell Differentiation Regionalization Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Female Gonad Development Cellular Response To Starvation Response To Xenobiotic Stimulus Dorsal/ventral Axis Specification Anterior/posterior Pattern Specification Regulation Of Cell Cycle Process Negative Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Neuron Projection Development Neural Crest Cell Fate Commitment Wnt Signaling Pathway Neural Tube Development Hemopoiesis Cell Differentiation Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Ossification Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Osteoclast Differentiation Negative Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Osteoblast Proliferation Somatic Stem Cell Population Maintenance Non-canonical Wnt Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of B Cell Differentiation Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Osteoclast Differentiation Regulation Of Angiogenesis Positive Regulation Of Smoothened Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Development Of Primary Male Sexual Characteristics Negative Regulation Of Bone Remodeling Negative Regulation Of Fibroblast Proliferation Digestive Tract Morphogenesis Stem Cell Differentiation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Hematopoietic Stem Cell Differentiation Bone Trabecula Formation Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Regulation Of Branching Involved In Prostate Gland Morphogenesis Negative Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Vitamin D Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Prostaglandin E Stimulus Cellular Response To Estrogen Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Hypoxia Cellular Response To X-ray Dopaminergic Neuron Differentiation Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To BMP Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Establishment Of Planar Polarity Wnt Signaling Pathway Involved In Somitogenesis Convergent Extension Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Midbrain Dopaminergic Neuron Differentiation Positive Regulation Of Non-canonical Wnt Signaling Pathway Negative Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		TCF dependent signaling in response to WNT TCF dependent signaling in response to WNT WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors) Transcriptional regulation of white adipocyte differentiation PCP/CE pathway PCP/CE pathway Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane	TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Heel bone mineral density ( 28869591 30598549)	Academic attainment (English) ( 33594131) Anti-saccade response ( 29064472) Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Refractive astigmatism ( 30306274)
Interacting Genes		9 interacting genes: FZD8 FZD9 LRP5 LRP6 PORCN RYK SFRP1 SFRP2 WNT3A	8 interacting genes: FZD6 NHSL3 PPP1CA PPP1CC TMEM86B WNT1 WNT2 WNT4
Entrez ID		7471	6422
HPRD ID		01276	09165
Ensembl ID		ENSG00000125084	ENSG00000104332
Uniprot IDs		P04628	Q8N474
PDB IDs
Enriched GO Terms of Interacting Partners?		Wnt-protein Binding Canonical Wnt Signaling Pathway Wnt Signaling Pathway Wnt-Frizzled-LRP5/6 Complex Wnt Receptor Activity Non-canonical Wnt Signaling Pathway Frizzled Binding Dopaminergic Neuron Differentiation Regulation Of Dopaminergic Neuron Differentiation Cell Surface Receptor Signaling Pathway Midbrain Dopaminergic Neuron Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway Neuron Differentiation Regulation Of Fat Cell Differentiation Wnt Signaling Pathway Involved In Somitogenesis Regulation Of Midbrain Dopaminergic Neuron Differentiation Positive Regulation Of Wnt Signaling Pathway Anterior/posterior Pattern Specification Negative Regulation Of Cell Growth Somitogenesis Development Of Primary Male Sexual Characteristics Positive Regulation Of Neural Precursor Cell Proliferation Segmentation Positive Regulation Of Cell Population Proliferation Coreceptor Activity Convergent Extension Involved In Axis Elongation Negative Regulation Of Growth Toxin Transmembrane Transporter Activity Regulation Of Establishment Of Planar Polarity Positive Regulation Of Fat Cell Differentiation Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Axon Extension Involved In Axon Guidance Development Of Primary Sexual Characteristics Regulation Of Mesodermal Cell Differentiation Regionalization Regulation Of Animal Organ Morphogenesis Cellular Response To X-ray Tube Morphogenesis Regulation Of Neural Precursor Cell Proliferation Cellular Developmental Process Negative Regulation Of Cell Differentiation Wnt Signalosome Regulation Of Wnt Signaling Pathway Convergent Extension Morphogenesis Of An Epithelium Tissue Development Signal Transduction Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Locomotion Anatomical Structure Formation Involved In Morphogenesis	Cell Proliferation In Midbrain Canonical Wnt Signaling Pathway Positive Regulation Of Dermatome Development Frizzled Binding PTW/PP1 Phosphatase Complex Wnt Signaling Pathway Regulation Of Embryonic Development Mammary Gland Epithelium Development Neural Precursor Cell Proliferation Midbrain Dopaminergic Neuron Differentiation Cell Population Proliferation Neuron Differentiation Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Embryonic Development Receptor Ligand Activity Tissue Morphogenesis Central Nervous System Neuron Differentiation Entrainment Of Circadian Clock By Photoperiod Morphogenesis Of A Branching Epithelium Protein Phosphatase 1 Binding Morphogenesis Of A Branching Structure Photoperiodism Entrainment Of Circadian Clock Cell Fate Commitment Developmental Induction Midbrain Development Dopaminergic Neuron Differentiation Cytokine Activity Branching Involved In Ureteric Bud Morphogenesis T Cell Differentiation In Thymus Cell Activation Non-canonical Wnt Signaling Pathway T Cell Activation Tube Morphogenesis Glycogen Metabolic Process Midbrain-hindbrain Boundary Maturation During Brain Development Cerebellum Formation Positive Regulation Of Fibroblast Proliferation Inner Ear Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Male Gonad Development Positive Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Androgen Biosynthetic Process Metanephric Nephron Morphogenesis Negative Regulation Of Testicular Blood Vessel Morphogenesis D-lysine 5,6-aminomutase Activity Circadian Regulation Of Gene Expression Regulation Of Morphogenesis Of An Epithelium Morphogenesis Of An Epithelium Anatomical Structure Morphogenesis
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