WNT1 and FZD8

Number of citations of the paper that reports this interaction (PubMedID 15454084)
0

Data Source:
HPRD (in vivo)

		WNT1	FZD8
Description		Wnt family member 1	frizzled class receptor 8
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Endocytic Vesicle Membrane Extracellular Exosome	Golgi Apparatus Plasma Membrane Membrane Neuronal Dense Core Vesicle Wnt-Frizzled-LRP5/6 Complex
	Molecular Function	Signaling Receptor Binding Frizzled Binding Cytokine Activity Morphogen Activity Protein Domain Specific Binding Receptor Ligand Activity	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Signaling Receptor Binding Protein Binding Wnt-protein Binding PDZ Domain Binding Ubiquitin Protein Ligase Binding Wnt Receptor Activity
	Biological Process	Embryonic Axis Specification Branching Involved In Ureteric Bud Morphogenesis Cell-cell Signaling Myoblast Fusion Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Response To Wounding Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Cell-substrate Adhesion Myotube Differentiation Wnt Signaling Pathway Spinal Cord Association Neuron Differentiation Diencephalon Development Cerebellum Development Central Nervous System Morphogenesis Cerebellum Formation Forebrain Anterior/posterior Pattern Specification Midbrain-hindbrain Boundary Maturation During Brain Development Neurogenesis Metencephalon Development Negative Regulation Of Cell-cell Adhesion Neuron Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Midbrain Development Midbrain-hindbrain Boundary Development Animal Organ Regeneration T Cell Differentiation In Thymus Cell Proliferation In Midbrain Astrocyte-dopaminergic Neuron Signaling Inner Ear Morphogenesis Signal Transduction In Response To DNA Damage Negative Regulation Of Apoptotic Process Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cell Fate Commitment Fat Cell Differentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation Neuron Fate Commitment Neuron Fate Determination Spemann Organizer Formation Canonical Wnt Signaling Pathway Bone Development Positive Regulation Of Dermatome Development Hepatocyte Differentiation Cellular Response To Peptide Hormone Stimulus Hematopoietic Stem Cell Proliferation Dopaminergic Neuron Differentiation Positive Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Midbrain Dopaminergic Neuron Differentiation Embryonic Brain Development Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Senescence	Angiogenesis Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Wnt Signaling Pathway Neuron Differentiation T Cell Differentiation In Thymus Non-canonical Wnt Signaling Pathway Canonical Wnt Signaling Pathway
Pathways		TCF dependent signaling in response to WNT TCF dependent signaling in response to WNT WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors) Transcriptional regulation of white adipocyte differentiation PCP/CE pathway PCP/CE pathway Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane	Class B/2 (Secretin family receptors) Asymmetric localization of PCP proteins Regulation of FZD by ubiquitination Signaling by RNF43 mutants
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Heel bone mineral density ( 28869591 30598549)	Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Periodontal microbiota ( 22699663) Protein quantitative trait loci ( 18464913)
Interacting Genes		9 interacting genes: FZD8 FZD9 LRP5 LRP6 PORCN RYK SFRP1 SFRP2 WNT3A	5 interacting genes: GOPC LRP5 LRP6 RYK WNT1
Entrez ID		7471	8325
HPRD ID		01276	05852
Ensembl ID		ENSG00000125084	ENSG00000177283
Uniprot IDs		P04628	Q9H461
PDB IDs			5UN5 5UN6 6NDZ 8X0T
Enriched GO Terms of Interacting Partners?		Wnt-protein Binding Canonical Wnt Signaling Pathway Wnt Signaling Pathway Wnt-Frizzled-LRP5/6 Complex Wnt Receptor Activity Non-canonical Wnt Signaling Pathway Frizzled Binding Dopaminergic Neuron Differentiation Regulation Of Dopaminergic Neuron Differentiation Cell Surface Receptor Signaling Pathway Midbrain Dopaminergic Neuron Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway Neuron Differentiation Regulation Of Fat Cell Differentiation Wnt Signaling Pathway Involved In Somitogenesis Regulation Of Midbrain Dopaminergic Neuron Differentiation Positive Regulation Of Wnt Signaling Pathway Anterior/posterior Pattern Specification Negative Regulation Of Cell Growth Somitogenesis Development Of Primary Male Sexual Characteristics Positive Regulation Of Neural Precursor Cell Proliferation Segmentation Positive Regulation Of Cell Population Proliferation Coreceptor Activity Convergent Extension Involved In Axis Elongation Negative Regulation Of Growth Toxin Transmembrane Transporter Activity Regulation Of Establishment Of Planar Polarity Positive Regulation Of Fat Cell Differentiation Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Axon Extension Involved In Axon Guidance Development Of Primary Sexual Characteristics Regulation Of Mesodermal Cell Differentiation Regionalization Regulation Of Animal Organ Morphogenesis Cellular Response To X-ray Tube Morphogenesis Regulation Of Neural Precursor Cell Proliferation Cellular Developmental Process Negative Regulation Of Cell Differentiation Wnt Signalosome Regulation Of Wnt Signaling Pathway Convergent Extension Morphogenesis Of An Epithelium Tissue Development Signal Transduction Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Locomotion Anatomical Structure Formation Involved In Morphogenesis	Midbrain Dopaminergic Neuron Differentiation Wnt Receptor Activity Canonical Wnt Signaling Pathway Wnt-protein Binding Frizzled Binding Dopaminergic Neuron Differentiation Wnt-Frizzled-LRP5/6 Complex Coreceptor Activity Wnt Signaling Pathway Toxin Transmembrane Transporter Activity Wnt Signalosome Central Nervous System Neuron Differentiation Midbrain Development Response To Peptide Hormone Neuron Differentiation Bone Development Midbrain-hindbrain Boundary Maturation During Brain Development Cerebellum Formation Negative Regulation Of Anion Channel Activity Cell-cell Signaling Involved In Mammary Gland Development Chemorepulsion Of Dopaminergic Neuron Axon Positive Regulation Of Cell Proliferation In Midbrain Central Nervous System Morphogenesis Diencephalon Development Neurogenesis Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Dermatome Development Astrocyte-dopaminergic Neuron Signaling Metencephalon Development Regulation Of Fat Cell Differentiation Cell-cell Signaling Signaling Response To Hormone Morphogenesis Of A Branching Epithelium Norrin Signaling Pathway Forebrain Anterior/posterior Pattern Specification Spemann Organizer Formation Glial Cell-neuron Signaling Midbrain-hindbrain Boundary Development Cell Communication Morphogenesis Of A Branching Structure Anterior/posterior Pattern Specification Mesodermal Cell Migration Apoptotic Process Involved In Blood Vessel Morphogenesis Negative Regulation Of Cell Differentiation Extracellular Matrix-cell Signaling Cell Proliferation In Midbrain Retinal Blood Vessel Morphogenesis Establishment Of Blood-retinal Barrier Chemorepulsion Of Axon
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