WNT1 and WNT3A

Number of citations of the paper that reports this interaction (PubMedID 10557084)
0

Data Source:
HPRD (in vivo)

		WNT1	WNT3A
Description		Wnt family member 1	Wnt family member 3A
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Endocytic Vesicle Membrane Extracellular Exosome	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Endocytic Vesicle Membrane Early Endosome Membrane Synapse Extracellular Exosome Presynapse Glutamatergic Synapse Wnt-Frizzled-LRP5/6 Complex
	Molecular Function	Signaling Receptor Binding Frizzled Binding Cytokine Activity Morphogen Activity Protein Domain Specific Binding Receptor Ligand Activity	Transcription Coactivator Activity Signaling Receptor Binding Frizzled Binding Cytokine Activity Protein Binding Protein Domain Specific Binding Co-receptor Binding Identical Protein Binding Receptor Ligand Activity
	Biological Process	Embryonic Axis Specification Branching Involved In Ureteric Bud Morphogenesis Cell-cell Signaling Myoblast Fusion Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Response To Wounding Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Cell-substrate Adhesion Myotube Differentiation Wnt Signaling Pathway Spinal Cord Association Neuron Differentiation Diencephalon Development Cerebellum Development Central Nervous System Morphogenesis Cerebellum Formation Forebrain Anterior/posterior Pattern Specification Midbrain-hindbrain Boundary Maturation During Brain Development Neurogenesis Metencephalon Development Negative Regulation Of Cell-cell Adhesion Neuron Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Midbrain Development Midbrain-hindbrain Boundary Development Animal Organ Regeneration T Cell Differentiation In Thymus Cell Proliferation In Midbrain Astrocyte-dopaminergic Neuron Signaling Inner Ear Morphogenesis Signal Transduction In Response To DNA Damage Negative Regulation Of Apoptotic Process Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cell Fate Commitment Fat Cell Differentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation Neuron Fate Commitment Neuron Fate Determination Spemann Organizer Formation Canonical Wnt Signaling Pathway Bone Development Positive Regulation Of Dermatome Development Hepatocyte Differentiation Cellular Response To Peptide Hormone Stimulus Hematopoietic Stem Cell Proliferation Dopaminergic Neuron Differentiation Positive Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Midbrain Dopaminergic Neuron Differentiation Embryonic Brain Development Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Senescence	Osteoblast Differentiation In Utero Embryonic Development Somitogenesis Positive Regulation Of Cytokine Production Heart Looping Positive Regulation Of Receptor Internalization Transcription By RNA Polymerase II Determination Of Left/right Symmetry Axonogenesis Axon Guidance Mesoderm Development Heart Development Intracellular Protein Localization Positive Regulation Of Cell Population Proliferation Anterior/posterior Pattern Specification COP9 Signalosome Assembly Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Neuron Projection Development Wnt Signaling Pathway Spinal Cord Association Neuron Differentiation Hippocampus Development Cell Proliferation In Forebrain Wnt Signaling Pathway Involved In Forebrain Neuroblast Division Dorsal/ventral Neural Tube Patterning Neurogenesis Hemopoiesis Platelet Activation Neuron Differentiation Extracellular Matrix Organization Mammary Gland Development Positive Regulation Of B Cell Proliferation Midbrain Development Cell Proliferation In Midbrain Non-canonical Wnt Signaling Pathway Skeletal Muscle Cell Differentiation Post-anal Tail Morphogenesis Synaptic Vesicle Recycling B Cell Proliferation Inner Ear Morphogenesis Cell Fate Commitment Fat Cell Differentiation Myoblast Differentiation Regulation Of Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Somatic Stem Cell Division Positive Regulation Of Mesodermal Cell Fate Specification Paraxial Mesodermal Cell Fate Commitment Animal Organ Development Positive Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Collateral Sprouting In Absence Of Injury Negative Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Neurogenesis Regulation Of Axonogenesis Modulation Of Chemical Synaptic Transmission Regulation Of Synapse Organization Canonical Wnt Signaling Pathway Cardiac Muscle Cell Fate Commitment Positive Regulation Of Dermatome Development Secondary Palate Development Regulation Of Microtubule Cytoskeleton Organization Platelet Aggregation Cellular Response To Retinoic Acid Axis Elongation Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Calcium Ion Transmembrane Transport Via Low Voltage-gated Calcium Channel Presynapse Assembly Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Dopaminergic Neuron Differentiation Midbrain Dopaminergic Neuron Differentiation Regulation Of Postsynapse To Nucleus Signaling Pathway Regulation Of Presynapse Assembly Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Cardiac Muscle Cell Differentiation Regulation Of RNA Biosynthetic Process
Pathways		TCF dependent signaling in response to WNT TCF dependent signaling in response to WNT WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors) Transcriptional regulation of white adipocyte differentiation PCP/CE pathway PCP/CE pathway Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane	TCF dependent signaling in response to WNT TCF dependent signaling in response to WNT WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors) Negative regulation of TCF-dependent signaling by WNT ligand antagonists Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Regulation of FZD by ubiquitination Signaling by RNF43 mutants Formation of paraxial mesoderm Formation of the posterior neural plate Specification of the neural plate border Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Heel bone mineral density ( 28869591 30598549)	Alcohol-related hepatocellular carcinoma ( 34902334) Birth weight ( 31043758) Diastolic blood pressure ( 28135244) Height ( 31562340) Medication use (agents acting on the renin-angiotensin system) ( 31015401)
Interacting Genes		9 interacting genes: FZD8 FZD9 LRP5 LRP6 PORCN RYK SFRP1 SFRP2 WNT3A	11 interacting genes: DLG1 DLG2 DLG4 FZD1 GPC3 LRP1 LRP6 PORCN RYK WNT1 WNT2
Entrez ID		7471	89780
HPRD ID		01276	05897
Ensembl ID		ENSG00000125084	ENSG00000154342
Uniprot IDs		P04628	P56704
PDB IDs			7DRT 7URD 7URE 8TZR
Enriched GO Terms of Interacting Partners?		Wnt-protein Binding Canonical Wnt Signaling Pathway Wnt Signaling Pathway Wnt-Frizzled-LRP5/6 Complex Wnt Receptor Activity Non-canonical Wnt Signaling Pathway Frizzled Binding Dopaminergic Neuron Differentiation Regulation Of Dopaminergic Neuron Differentiation Cell Surface Receptor Signaling Pathway Midbrain Dopaminergic Neuron Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway Neuron Differentiation Regulation Of Fat Cell Differentiation Wnt Signaling Pathway Involved In Somitogenesis Regulation Of Midbrain Dopaminergic Neuron Differentiation Positive Regulation Of Wnt Signaling Pathway Anterior/posterior Pattern Specification Negative Regulation Of Cell Growth Somitogenesis Development Of Primary Male Sexual Characteristics Positive Regulation Of Neural Precursor Cell Proliferation Segmentation Positive Regulation Of Cell Population Proliferation Coreceptor Activity Convergent Extension Involved In Axis Elongation Negative Regulation Of Growth Toxin Transmembrane Transporter Activity Regulation Of Establishment Of Planar Polarity Positive Regulation Of Fat Cell Differentiation Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Axon Extension Involved In Axon Guidance Development Of Primary Sexual Characteristics Regulation Of Mesodermal Cell Differentiation Regionalization Regulation Of Animal Organ Morphogenesis Cellular Response To X-ray Tube Morphogenesis Regulation Of Neural Precursor Cell Proliferation Cellular Developmental Process Negative Regulation Of Cell Differentiation Wnt Signalosome Regulation Of Wnt Signaling Pathway Convergent Extension Morphogenesis Of An Epithelium Tissue Development Signal Transduction Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Locomotion Anatomical Structure Formation Involved In Morphogenesis	Midbrain Dopaminergic Neuron Differentiation Canonical Wnt Signaling Pathway Frizzled Binding Dopaminergic Neuron Differentiation Wnt Signaling Pathway Wnt-protein Binding Central Nervous System Neuron Differentiation Cell-cell Signaling Signaling Cell Communication Wnt Signalosome Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Wnt Receptor Activity Cell Surface Receptor Signaling Pathway Anatomical Structure Morphogenesis Postsynaptic Density Membrane Ionotropic Glutamate Receptor Binding Astrocyte-dopaminergic Neuron Signaling Positive Regulation Of Cellular Component Organization Neuron Differentiation Branching Involved In Ureteric Bud Morphogenesis Glial Cell-neuron Signaling Tissue Morphogenesis Receptor Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Non-canonical Wnt Signaling Pathway Cell Proliferation In Midbrain Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Synapse Signal Transduction Hard Palate Development GMP Kinase Activity Endocytic Vesicle Membrane Neuromuscular Junction Protein Localization To Cell Junction GDP Metabolic Process Juxtaparanode Region Of Axon Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Tube Morphogenesis Protein Localization To Membrane Chemical Synaptic Transmission Kinase Binding Cellular Response To Potassium Ion Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Low-density Lipoprotein Particle Receptor Activity Developmental Process Trans-synaptic Signaling Regulation Of BMP Signaling Pathway Neurogenesis
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