TFAP2B and YEATS4

Number of citations of the paper that reports this interaction (PubMedID 16698963)
49

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vitro, in vivo, two hybrid)

		TFAP2B	YEATS4
Description		transcription factor AP-2 beta	YEATS domain containing 4
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Nucleosome Nucleus Nucleoplasm Nuclear Matrix Nuclear Membrane NuA4 Histone Acetyltransferase Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding	Structural Constituent Of Cytoskeleton Protein Binding Histone Binding Histone H3K18ac Reader Activity Histone H3K27ac Reader Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Glucose Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Nervous System Development Sensory Organ Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Gene Expression Retina Layer Formation Regulation Of BMP Signaling Pathway Forelimb Morphogenesis Hindlimb Morphogenesis Aorta Morphogenesis Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Skin Development Fat Cell Differentiation Regulation Of Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Sympathetic Nervous System Development Smooth Muscle Tissue Development Regulation Of Insulin Secretion Neuron Apoptotic Process Distal Tubule Development Collecting Duct Development Metanephric Nephron Development Ductus Arteriosus Closure	Mitotic Cell Cycle Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cytoskeleton Organization Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair
Pathways		SUMOylation of transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Activation of the TFAP2 (AP-2) family of transcription factors TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Specification of the neural plate border Specification of the neural plate border	HATs acetylate histones Activation of the TFAP2 (AP-2) family of transcription factors
Drugs
Diseases		Char syndrome
GWAS		Adiposity ( 19557161) Adult body size ( 32376654) Age at adiposity rebound ( 31840077) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Blood urea nitrogen levels ( 31152163 29403010) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body fat distribution (arm fat ratio) ( 30664634) Body mass index ( 31453325 29381148 28892062 20935630 28448500 24861553 26961502 23563607 25673413) Body mass index (adult) ( 28430825) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body mass index variance ( 31453325) Body size at age 10 ( 32376654) Childhood body mass index ( 33045005 26604143) Chronotype ( 30696823) Fruit consumption ( 32066663) Glaucoma (primary open-angle) ( 33627673) Hand grip strength ( 29691431) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hip circumference ( 31453325 25673412) Hip circumference variance ( 31453325) Intraocular pressure ( 29617998) Keratoconus ( 33649486) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (drugs used in diabetes) ( 31015401) Metabolic syndrome (bivariate traits) ( 21386085) Myopia ( 27182965) Nevus count or cutaneous melanoma ( 32341527) Obese vs. thin ( 30677029) Obesity ( 23563607) Obesity (extreme) ( 21935397) Refractive error ( 32231278) Renal function-related traits (BUN) ( 22797727) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Type 2 diabetes ( 30054458 32499647 30297969) Urolithiasis ( 30975718) Waist circumference ( 25673412 31453325) Waist circumference variance ( 31453325) Waist-hip ratio ( 25673412) Walking pace ( 33128006)	Complete remission in asthma ( 29786918) Height ( 18391951 31562340) Metabolite levels ( 23823483) Response to antidepressants (symptom remission) ( 29160301) Response to diuretic therapy ( 18591461) Response to SSRI in MDD or conscientiousness ( 29559929) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		12 interacting genes: AURKA CITED1 CITED2 CITED4 H2AC6 LZTR1 MYC SSBP4 SYT4 UBE2I VPS11 YEATS4	16 interacting genes: CEP162 FRMD4A GTF2F2 H3C1 MLLT10 MRGBP MYCN NUMA1 PFDN1 RNF8 SMARCB1 TACC1 TACC2 TFAP2B TPM1 TRIM54
Entrez ID		7021	8089
HPRD ID		03360	03666
Ensembl ID		ENSG00000008196	ENSG00000127337
Uniprot IDs		Q92481	F8W0J4 O95619
PDB IDs		8J0Q	5R68 5R69 5VNA 5VNB 5XTZ 5Y8V 7EIF 7JFY 8DKB 8I60 8IIY 8IIZ 8IJ0 8X15 8X19 8X1C
Enriched GO Terms of Interacting Partners?		Regulation Of Kidney Development Cellular Response To Decreased Oxygen Levels Cellular Response To Hypoxia Cellular Response To Oxygen Levels LBD Domain Binding Perinuclear Region Of Cytoplasm Response To Estrogen Vasculogenesis Positive Regulation Of Reproductive Process Tube Morphogenesis Response To Hypoxia Response To Decreased Oxygen Levels Response To Growth Factor Branching Morphogenesis Of An Epithelial Tube Morphogenesis Of An Epithelium Response To Oxygen Levels Molecular Function Activator Activity Morphogenesis Of A Branching Structure Morphogenesis Of A Branching Epithelium Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription Tissue Morphogenesis Nucleoplasm Regulation Of DNA Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Branching Involved In Ureteric Bud Morphogenesis Pigmentation Negative Regulation Of Apoptotic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Regulation Of Cell Division Transcription Coregulator Binding Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Regulation Of Reproductive Process Positive Regulation Of Dense Core Granule Exocytosis Negative Regulation Of Retrograde Trans-synaptic Signaling By Neuropeptide Regulation Of Postsynaptic Dense Core Vesicle Exocytosis Negative Regulation Of Short-term Neuronal Synaptic Plasticity SUMO Conjugating Enzyme Activity VEGF-A Complex Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Basophil Chemotaxis Regulation Of Primary Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Metabolic Process Regulation Of Apoptotic Process	Nucleoplasm RNA Polymerase II, Holoenzyme Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Epigenetic Regulation Of Gene Expression Cortical Microtubule Spindle Organization Anastral Spindle Assembly Cytoplasmic Microtubule Bundle Positive Regulation Of Protein Localization To Spindle Pole Body Protein-containing Complex Cytoskeleton Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Supramolecular Fiber Organization Positive Regulation Of Mitotic Spindle Elongation Positive Regulation Of Double-strand Break Repair Regulation Of Double-strand Break Repair Positive Regulation Of DNA Repair Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Nuclear Receptor Binding Nucleus Localization Nuclear Migration Positive Regulation Of Heart Rate By Epinephrine Positive Regulation Of Double-strand Break Repair Via Homologous Recombination H4/H2A Histone Acetyltransferase Complex Regulation Of DNA Repair Regulation Of Epidermal Cell Differentiation Transcription Factor TFIIF Complex Regulation Of Epidermis Development Establishment Of Organelle Localization Lateral Cell Cortex Positive Regulation Of DNA Metabolic Process Nucleus Chromatin Remodeling Cell Cortex Region Centrosome Positive Regulation Of Glucose Mediated Signaling Pathway Germ Cell Nucleus Cerebral Cortex Development Metanephric Nephron Development Positive Regulation Of DNA Recombination Regulation Of Double-strand Break Repair Via Homologous Recombination Mitotic Spindle Astral Microtubule Microtubule Regulation Of Glucose Mediated Signaling Pathway Mitotic Spindle Organization Distal Tubule Development
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