TFAP2B and CITED4

Number of citations: 0 (PubMedID 11744733)
Data Source: HPRD (in vitro)

		TFAP2B	CITED4
Name		transcription factor AP-2 beta	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4
Structure			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding	Transcription Coactivator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Glucose Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Nervous System Development Sensory Organ Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Gene Expression Retina Layer Formation Regulation Of BMP Signaling Pathway Forelimb Morphogenesis Hindlimb Morphogenesis Aorta Morphogenesis Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Skin Development Fat Cell Differentiation Regulation Of Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Sympathetic Nervous System Development Smooth Muscle Tissue Development Regulation Of Insulin Secretion Neuron Apoptotic Process Distal Tubule Development Collecting Duct Development Metanephric Nephron Development Ductus Arteriosus Closure	Regulation Of DNA-templated Transcription Response To Estrogen Positive Regulation Of DNA-templated Transcription
Pathways		SUMOylation of transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Activation of the TFAP2 (AP-2) family of transcription factors TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Specification of the neural plate border Specification of the neural plate border	Activation of the TFAP2 (AP-2) family of transcription factors
Diseases		Char syndrome	None
GWAS		Adiposity ( 19557161 ) Adult body size ( 32376654 ) Age at adiposity rebound ( 31840077 ) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Bipolar disorder ( 31043756 ) Bipolar I disorder ( 31043756 ) Blood urea nitrogen levels ( 31152163 29403010 ) BMI (adjusted for smoking behaviour) ( 28443625 ) BMI in non-smokers ( 28443625 ) BMI in smokers ( 28443625 ) Body fat distribution (arm fat ratio) ( 30664634 ) Body mass index ( 31453325 29381148 28892062 20935630 28448500 24861553 26961502 23563607 25673413 ) Body mass index (adult) ( 28430825 ) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500 ) Body mass index (joint analysis main effects and smoking interaction) ( 28443625 ) Body mass index in physically active individuals ( 28448500 ) Body mass index in physically inactive individuals ( 28448500 ) Body mass index variance ( 31453325 ) Body size at age 10 ( 32376654 ) Childhood body mass index ( 33045005 26604143 ) Chronotype ( 30696823 ) Fruit consumption ( 32066663 ) Glaucoma (primary open-angle) ( 33627673 ) Hand grip strength ( 29691431 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Hip circumference ( 31453325 25673412 ) Hip circumference variance ( 31453325 ) Intraocular pressure ( 29617998 ) Keratoconus ( 33649486 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Medication use (drugs used in diabetes) ( 31015401 ) Metabolic syndrome (bivariate traits) ( 21386085 ) Myopia ( 27182965 ) Nevus count or cutaneous melanoma ( 32341527 ) Obese vs. thin ( 30677029 ) Obesity ( 23563607 ) Obesity (extreme) ( 21935397 ) Refractive error ( 32231278 ) Renal function-related traits (BUN) ( 22797727 ) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814 ) Smoking status (ever vs never smokers) ( 30643258 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Type 2 diabetes ( 30054458 32499647 30297969 ) Urolithiasis ( 30975718 ) Waist circumference ( 25673412 31453325 ) Waist circumference variance ( 31453325 ) Waist-hip ratio ( 25673412 ) Walking pace ( 33128006 )	No GWAS studies recorded
Interacting Genes		12 interacting genes: AURKA CITED1 CITED2 CITED4 H2AC6 LZTR1 MYC SSBP4 SYT4 UBE2I VPS11 YEATS4	4 interacting genes: EP300 TFAP2A TFAP2B TFAP2C
Entrez ID		7021	163732
HPRD ID		03360	06011
Ensembl ID		ENSG00000008196	ENSG00000179862
Uniprot IDs		Q92481	Q96RK1
PDB IDs		8J0Q	Not available
GO Terms Enriched among Interactors		Regulation Of Kidney Development Cellular Response To Decreased Oxygen Levels Cellular Response To Hypoxia Cellular Response To Oxygen Levels LBD Domain Binding Perinuclear Region Of Cytoplasm Response To Estrogen Vasculogenesis Positive Regulation Of Reproductive Process Tube Morphogenesis Response To Hypoxia Response To Decreased Oxygen Levels Response To Growth Factor Branching Morphogenesis Of An Epithelial Tube Morphogenesis Of An Epithelium Response To Oxygen Levels Molecular Function Activator Activity Morphogenesis Of A Branching Structure Morphogenesis Of A Branching Epithelium Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription Tissue Morphogenesis Nucleoplasm Regulation Of DNA Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Branching Involved In Ureteric Bud Morphogenesis Pigmentation Negative Regulation Of Apoptotic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Regulation Of Cell Division Transcription Coregulator Binding Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Regulation Of Reproductive Process Positive Regulation Of Dense Core Granule Exocytosis Negative Regulation Of Retrograde Trans-synaptic Signaling By Neuropeptide Regulation Of Postsynaptic Dense Core Vesicle Exocytosis Negative Regulation Of Short-term Neuronal Synaptic Plasticity SUMO Conjugating Enzyme Activity VEGF-A Complex Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Basophil Chemotaxis Regulation Of Primary Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Metabolic Process Regulation Of Apoptotic Process	Regulation Of Developmental Process Negative Regulation Of Transcription By RNA Polymerase II Chromatin Positive Regulation Of Biosynthetic Process Anatomical Structure Formation Involved In Morphogenesis Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Retina Layer Formation Forelimb Morphogenesis RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Skin Development DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Animal Organ Development Negative Regulation Of RNA Biosynthetic Process Peptidyl-lysine Propionylation Anatomical Structure Morphogenesis Swimming Negative Regulation Of Nucleobase-containing Compound Metabolic Process Histone Lactyltransferase (CoA-dependent) Activity Negative Regulation Of RNA Metabolic Process Peptidyl-lysine Butyrylation Negative Regulation Of DNA-templated Transcription Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Chromatin Binding Histone Crotonyltransferase Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Optic Cup Structural Organization DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Metabolic Process Regulation Of Cell Differentiation Positive Regulation Of Programmed Cell Death Nervous System Development Sequence-specific Double-stranded DNA Binding Limb Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Positive Regulation Of RNA Metabolic Process Protein Propionyltransferase Activity Fat Cell Differentiation Positive Regulation Of T Cell Differentiation Histone H3K27 Acetyltransferase Activity