TFAP2B and SSBP4

Number of citations: 41 (PubMedID 20211142)
Data Source: BioGRID (two hybrid)

		TFAP2B	SSBP4
Name		transcription factor AP-2 beta	single stranded DNA binding protein 4
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Nucleus
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding	DNA Binding Single-stranded DNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Glucose Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Nervous System Development Sensory Organ Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Gene Expression Retina Layer Formation Regulation Of BMP Signaling Pathway Forelimb Morphogenesis Hindlimb Morphogenesis Aorta Morphogenesis Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Skin Development Fat Cell Differentiation Regulation Of Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Sympathetic Nervous System Development Smooth Muscle Tissue Development Regulation Of Insulin Secretion Neuron Apoptotic Process Distal Tubule Development Collecting Duct Development Metanephric Nephron Development Ductus Arteriosus Closure	Positive Regulation Of Transcription By RNA Polymerase II
Pathways		SUMOylation of transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Activation of the TFAP2 (AP-2) family of transcription factors TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Specification of the neural plate border Specification of the neural plate border	None
Diseases		Char syndrome	None
GWAS		Adiposity ( 19557161 ) Adult body size ( 32376654 ) Age at adiposity rebound ( 31840077 ) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Bipolar disorder ( 31043756 ) Bipolar I disorder ( 31043756 ) Blood urea nitrogen levels ( 31152163 29403010 ) BMI (adjusted for smoking behaviour) ( 28443625 ) BMI in non-smokers ( 28443625 ) BMI in smokers ( 28443625 ) Body fat distribution (arm fat ratio) ( 30664634 ) Body mass index ( 31453325 29381148 28892062 20935630 28448500 24861553 26961502 23563607 25673413 ) Body mass index (adult) ( 28430825 ) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500 ) Body mass index (joint analysis main effects and smoking interaction) ( 28443625 ) Body mass index in physically active individuals ( 28448500 ) Body mass index in physically inactive individuals ( 28448500 ) Body mass index variance ( 31453325 ) Body size at age 10 ( 32376654 ) Childhood body mass index ( 33045005 26604143 ) Chronotype ( 30696823 ) Fruit consumption ( 32066663 ) Glaucoma (primary open-angle) ( 33627673 ) Hand grip strength ( 29691431 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Hip circumference ( 31453325 25673412 ) Hip circumference variance ( 31453325 ) Intraocular pressure ( 29617998 ) Keratoconus ( 33649486 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Medication use (drugs used in diabetes) ( 31015401 ) Metabolic syndrome (bivariate traits) ( 21386085 ) Myopia ( 27182965 ) Nevus count or cutaneous melanoma ( 32341527 ) Obese vs. thin ( 30677029 ) Obesity ( 23563607 ) Obesity (extreme) ( 21935397 ) Refractive error ( 32231278 ) Renal function-related traits (BUN) ( 22797727 ) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814 ) Smoking status (ever vs never smokers) ( 30643258 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Type 2 diabetes ( 30054458 32499647 30297969 ) Urolithiasis ( 30975718 ) Waist circumference ( 25673412 31453325 ) Waist circumference variance ( 31453325 ) Waist-hip ratio ( 25673412 ) Walking pace ( 33128006 )	Alzheimer's disease (late onset) ( 30820047 ) Basophil count ( 32888494 ) Breast cancer ( 23535729 ) Intake of total sugars ( 31005972 ) Monocyte count ( 27863252 ) Systemic lupus erythematosus ( 28714469 33272962 33536424 )
Interacting Genes		12 interacting genes: AURKA CITED1 CITED2 CITED4 H2AC6 LZTR1 MYC SSBP4 SYT4 UBE2I VPS11 YEATS4	9 interacting genes: CRYAA IL36RN LDB1 LDB2 MYO15B PIK3R3 PIN1 SPG21 TFAP2B
Entrez ID		7021	170463
HPRD ID		03360	09579
Ensembl ID		ENSG00000008196	ENSG00000130511
Uniprot IDs		Q92481	Q9BWG4
PDB IDs		8J0Q	7OBX 7OBY
GO Terms Enriched among Interactors		Regulation Of Kidney Development Cellular Response To Decreased Oxygen Levels Cellular Response To Hypoxia Cellular Response To Oxygen Levels LBD Domain Binding Perinuclear Region Of Cytoplasm Response To Estrogen Vasculogenesis Positive Regulation Of Reproductive Process Tube Morphogenesis Response To Hypoxia Response To Decreased Oxygen Levels Response To Growth Factor Branching Morphogenesis Of An Epithelial Tube Morphogenesis Of An Epithelium Response To Oxygen Levels Molecular Function Activator Activity Morphogenesis Of A Branching Structure Morphogenesis Of A Branching Epithelium Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription Tissue Morphogenesis Nucleoplasm Regulation Of DNA Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Branching Involved In Ureteric Bud Morphogenesis Pigmentation Negative Regulation Of Apoptotic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Regulation Of Cell Division Transcription Coregulator Binding Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Regulation Of Reproductive Process Positive Regulation Of Dense Core Granule Exocytosis Negative Regulation Of Retrograde Trans-synaptic Signaling By Neuropeptide Regulation Of Postsynaptic Dense Core Vesicle Exocytosis Negative Regulation Of Short-term Neuronal Synaptic Plasticity SUMO Conjugating Enzyme Activity VEGF-A Complex Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Basophil Chemotaxis Regulation Of Primary Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Metabolic Process Regulation Of Apoptotic Process	LIM Domain Binding Hair Follicle Development Epithelial Structure Maintenance Negative Regulation Of Macromolecule Metabolic Process Cis-trans Isomerase Activity Somatic Stem Cell Population Maintenance Cell Leading Edge Hair Cycle Process Negative Regulation Of Metabolic Process Regulation Of Cell Motility Regulation Of Locomotion Protein Peptidyl-prolyl Isomerization Regulation Of Phosphorylation Phosphothreonine Residue Binding Metanephric Nephron Development Interleukin-1 Receptor Antagonist Activity Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Phosphorus Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Distal Tubule Development Ductus Arteriosus Closure Nervous System Development Stem Cell Population Maintenance Transcription Coregulator Activity Maintenance Of Cell Number Positive Regulation Of Hemoglobin Biosynthetic Process