RNF130 and UBE2E3

Number of citations of the paper that reports this interaction (PubMedID 19690564)
61

Data Source:
BioGRID (two hybrid)

		RNF130	UBE2E3
Description		ring finger protein 130	ubiquitin conjugating enzyme E2 E3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Programmed Cell Death Protein Ubiquitination	Protein Monoubiquitination Negative Regulation Of Gene Expression Protein Ubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		LDL cholesterol ( 21347282) Pre-treatment viral load in HIV-1 infection ( 31219150) Systolic blood pressure ( 30224653)	Ankylosing spondylitis ( 23749187) Basophil count ( 32888494) Body mass index ( 25673413) Celiac disease ( 22057235 20190752) Celiac disease and Rheumatoid arthritis ( 26546613) Heel bone mineral density ( 30598549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lymphocyte count ( 29403010) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Number of sexual partners ( 30643258) Obesity ( 21552555) QT interval ( 29213071) Red blood cell count ( 27863252 32888494) Risk-taking tendency (4-domain principal component model) ( 30643258) Serum alkaline phosphatase levels ( 33547301) Sweet taste preference ( 32572145) White blood cell count ( 27863252)
Interacting Genes		14 interacting genes: ARPC4 EGFR FGFR3 PDCD1 SCN2A TGFBR1 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2Z	95 interacting genes: ACVR1 ARID3A ARIH2 ARK2C ARRDC3 ASXL2 ATXN1 BARD1 BRCA1 CADPS2 CBL CHFR CHUK CNOT4 CUEDC1 CUL1 CUL3 CUL4A DAZAP2 DTX3 DTX3L DZIP3 HERC4 HMGB1 HTT IPO11 ITCH KLHL42 MARCHF5 MDM2 MID1 MID2 MKRN3 MUL1 NEDD4L NFKBIA PGPEP1 PICK1 PJA1 PRKN RANGAP1 RBX1 RC3H2 RCBTB1 RFWD3 RING1 RMND5B RNF11 RNF111 RNF114 RNF115 RNF126 RNF13 RNF130 RNF14 RNF150 RNF166 RNF167 RNF181 RNF185 RNF2 RNF31 RNF4 RNF43 RNF5 RNF8 SAE1 SIAH1 SPOP STUB1 TGFBR1 TRIM2 TRIM27 TRIM32 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 TRIM54 TRIM55 TRIM62 TRIM63 TTC3 UBA1 UBA6 UBC UBOX5 UFM1 WBP2 WWP2 ZNF746 ZNRF1 ZNRF2 ZNRF4
Entrez ID		55819	10477
HPRD ID		11504	05000
Ensembl ID		ENSG00000113269	ENSG00000170035
Uniprot IDs		E5RI87 Q2HIY3 Q86XS8	Q969T4
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination ATP Binding Ubiquitin-protein Transferase Activity Protein Polyubiquitination Nucleotide Binding Transferase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Monoubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification Process Protein K11-linked Ubiquitination Macromolecule Catabolic Process Proteolysis Protein K63-linked Ubiquitination Apoptotic Process Cell Death Programmed Cell Death Positive Regulation Of Protein Polyubiquitination Protein Metabolic Process Regulation Of Protein Modification Process Positive Regulation Of Protein Modification Process Protein K6-linked Ubiquitination Regulation Of Protein Polyubiquitination Catabolic Process Receptor Complex Regulation Of Protein Ubiquitination Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Multivesicular Body, Internal Vesicle Lumen Regulatory T Cell Apoptotic Process Negative Regulation Of Tolerance Induction Regulation Of Post-translational Protein Modification TORC1 Signaling Negative Regulation Of TORC1 Signaling Negative Regulation Of BMP Signaling Pathway Shc-EGFR Complex Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Vascular Endothelial Cell Proliferation Epicardium Morphogenesis Protein Autoubiquitination Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Ubiquitin Protein Ligase Binding Regulation Of Peptidyl-tyrosine Phosphorylation Intracellular Signal Transduction	Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Protein Polyubiquitination Protein Modification Process Ubiquitin-protein Transferase Activity Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process Macromolecule Catabolic Process Zinc Ion Binding Proteolysis Protein Autoubiquitination Macromolecule Metabolic Process Catabolic Process Protein K48-linked Ubiquitination Metal Ion Binding Cytoplasm Protein K63-linked Ubiquitination Protein Catabolic Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Protein Monoubiquitination Response To Stress Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Signal Transduction Ubiquitin Ligase Complex Positive Regulation Of Catabolic Process Protein Destabilization Protein K6-linked Ubiquitination Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Innate Immune Response Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Autophagy Defense Response To Symbiont Positive Regulation Of Metabolic Process Cellular Response To Stress Defense Response To Other Organism
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