RNF130 and PDCD1

Number of citations of the paper that reports this interaction (PubMedID 37011906)
67

Data Source:
BioGRID (pull down)

		RNF130	PDCD1
Description		ring finger protein 130	programmed cell death 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Membrane	Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Signaling Receptor Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Programmed Cell Death Protein Ubiquitination	B Cell Apoptotic Process Adaptive Immune Response Immune System Process Negative Regulation Of Tolerance Induction Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Negative Regulation Of B Cell Apoptotic Process Apoptotic Process Humoral Immune Response Regulation Of Immune Response Negative Regulation Of Immune Response Negative Regulation Of T Cell Activation Negative Regulation Of Multicellular Organismal Process Positive Regulation Of T Cell Apoptotic Process Regulatory T Cell Apoptotic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Co-inhibition by PD-1 Potential therapeutics for SARS PD-L1(CD274) glycosylation and translocation to plasma membrane
Drugs			CT-011 Nivolumab Pembrolizumab Atezolizumab Durvalumab Avelumab Cemiplimab Camrelizumab Spartalizumab Tislelizumab Toripalimab Dostarlimab Sintilimab Retifanlimab AMP-224 MEDI0680 Geptanolimab Budigalimab Prolgolimab
Diseases			Systemic lupus erythematosus
GWAS		LDL cholesterol ( 21347282) Pre-treatment viral load in HIV-1 infection ( 31219150) Systolic blood pressure ( 30224653)	Crohn's disease ( 26192919) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494)
Interacting Genes		14 interacting genes: ARPC4 EGFR FGFR3 PDCD1 SCN2A TGFBR1 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2Z	8 interacting genes: CD274 MAPK3 MDM2 PDCD1LG2 RNF128 RNF130 RNF167 USP5
Entrez ID		55819	5133
HPRD ID		11504	02590
Ensembl ID		ENSG00000113269	ENSG00000188389
Uniprot IDs		E5RI87 Q2HIY3 Q86XS8	A0A0M3M0G7 Q15116
PDB IDs			2M2D 3RRQ 4ZQK 5B8C 5GGR 5GGS 5IUS 5JXE 5WT9 6HIG 6J14 6J15 6JBT 6JJP 6K0Y 6R5G 6ROY 6ROZ 6UMT 6UMU 6UMV 6XKR 7BXA 7CGW 7CU5 7E9B 7VUX 7WSL 7WVM 8AS0 8EQ6 8GY5 8U31 8U32 9HK1
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination ATP Binding Ubiquitin-protein Transferase Activity Protein Polyubiquitination Nucleotide Binding Transferase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Monoubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification Process Protein K11-linked Ubiquitination Macromolecule Catabolic Process Proteolysis Protein K63-linked Ubiquitination Apoptotic Process Cell Death Programmed Cell Death Positive Regulation Of Protein Polyubiquitination Protein Metabolic Process Regulation Of Protein Modification Process Positive Regulation Of Protein Modification Process Protein K6-linked Ubiquitination Regulation Of Protein Polyubiquitination Catabolic Process Receptor Complex Regulation Of Protein Ubiquitination Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Multivesicular Body, Internal Vesicle Lumen Regulatory T Cell Apoptotic Process Negative Regulation Of Tolerance Induction Regulation Of Post-translational Protein Modification TORC1 Signaling Negative Regulation Of TORC1 Signaling Negative Regulation Of BMP Signaling Pathway Shc-EGFR Complex Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Vascular Endothelial Cell Proliferation Epicardium Morphogenesis Protein Autoubiquitination Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Ubiquitin Protein Ligase Binding Regulation Of Peptidyl-tyrosine Phosphorylation Intracellular Signal Transduction	Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Negative Regulation Of Immune Response To Tumor Cell Regulation Of T Cell Mediated Immune Response To Tumor Cell Regulation Of Response To Tumor Cell Protein Modification By Small Protein Conjugation Negative Regulation Of T Cell Activation Negative Regulation Of T Cell Mediated Immunity Negative Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Lymphocyte Activation Post-translational Protein Modification Negative Regulation Of Leukocyte Activation Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Activation Negative Regulation Of Adaptive Immune Response Protein Modification Process Endomembrane System Protein Ubiquitination Negative Regulation Of Cell Adhesion Negative Regulation Of Activated T Cell Proliferation Regulation Of T Cell Mediated Immunity Ubiquitin Protein Ligase Activity Regulation Of Protein Stability Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of T Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Proteolysis Negative Regulation Of Interleukin-10 Production Positive Regulation Of Leukocyte Proliferation Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Lymphocyte Mediated Immunity Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Immune System Process Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Immune Response Regulation Of Adaptive Immune Response Regulation Of Activated T Cell Proliferation Negative Regulation Of Type II Interferon Production Modification-dependent Protein Catabolic Process T Cell Costimulation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Metabolic Process Cellular Response To Nutrient Levels
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