RNF130 and SCN2A

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		RNF130	SCN2A
Gene Name		ring finger protein 130	sodium channel, voltage gated, type II alpha subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Integral Component Of Membrane	Voltage-gated Sodium Channel Complex Plasma Membrane Integral Component Of Plasma Membrane Intercalated Disc T-tubule Axon Intrinsic Component Of Plasma Membrane Node Of Ranvier Paranode Region Of Axon Sodium Channel Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity	Voltage-gated Sodium Channel Activity
	Biological Process	Apoptotic Process Programmed Cell Death Protein Ubiquitination	Sodium Ion Transport Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Myelination Neuron Apoptotic Process Membrane Depolarization During Action Potential
Pathways			Interaction between L1 and Ankyrins Axon guidance L1CAM interactions
Drugs
Diseases
GWAS		Coronary heart disease ( 21347282)
Protein-Protein Interactions		13 interactors: ARPC4 FGFR3 SCN2A TGFBR1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2Z	5 interactors: ANK3 ARHGEF10L MPP3 RNF130 SCN4B
Entrez ID		55819	6326
HPRD ID		11504	03133
Ensembl ID		ENSG00000113269	ENSG00000136531
Uniprot IDs		J3KN31 Q2HIY3 Q59EL1 Q86XS8	Q99250
PDB IDs			2KAV
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Toll-like Receptor 4 Signaling Pathway Regulation Of Protein Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Immune Response-regulating Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Activation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Cellular Protein Modification Process Regulation Of DNA-templated Transcription In Response To Stress TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Innate Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Innate Immune Response Regulation Of Immune Response Regulation Of Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Regulation Of Innate Immune Response Modification-dependent Protein Catabolic Process Cellular Response To Hypoxia Protein K11-linked Ubiquitination Cellular Response To Decreased Oxygen Levels Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Transferase Activity Cellular Protein Catabolic Process Cellular Response To Oxygen Levels Protein Catabolic Process Cellular Protein Metabolic Process Positive Regulation Of Immune Response Protein K63-linked Ubiquitination Transforming Growth Factor Beta Receptor Signaling Pathway Immune Response Regulation Of Immune System Process Negative Regulation Of Mitotic Nuclear Division Defense Response Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Negative Regulation Of Cell Cycle Cellular Macromolecule Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Enzyme Linked Receptor Protein Signaling Pathway	Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Sodium Ion Transport Regulation Of Sodium Ion Transport Action Potential Maintenance Of Protein Location In Plasma Membrane Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Negative Regulation Of Delayed Rectifier Potassium Channel Activity Positive Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Ion Transport Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Cellular Response To Magnesium Ion Regulation Of Membrane Depolarization During Action Potential AV Node Cell To Bundle Of His Cell Communication Regulation Of Membrane Potential Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Delayed Rectifier Potassium Channel Activity Positive Regulation Of Action Potential Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Cell Communication By Electrical Coupling Cytoskeletal Anchoring At Plasma Membrane Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Membrane Depolarization During Cardiac Muscle Cell Action Potential Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization SREBP Signaling Pathway Regulation Of Actin Filament-based Process Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Response To Sterol Depletion Positive Regulation Of Sodium Ion Transmembrane Transport Magnesium Ion Homeostasis Response To Magnesium Ion Negative Regulation Of Cation Channel Activity Negative Regulation Of Potassium Ion Transport Regulation Of Membrane Repolarization Membrane Assembly Regulation Of Heart Rate By Cardiac Conduction Golgi To Plasma Membrane Protein Transport Membrane Biogenesis Neuronal Action Potential Regulation Of Potassium Ion Transmembrane Transporter Activity Cardiac Muscle Cell Action Potential Involved In Contraction Positive Regulation Of Protein Targeting To Membrane Regulation Of Ion Transport Golgi To Plasma Membrane Transport Membrane Depolarization During Action Potential Regulation Of Membrane Depolarization Cardiac Muscle Cell Action Potential
Tagcloud ?			16p12 2q24 5q14 9q34 aetiology caln1 cdkl5 cgh cnv cnvs counselling ehmt1 encephalopathies encompassing epileptic etiological grin2a hypsarrhythmia infantile intronic iss kcnq2 magi2 mef2c microdeletions microduplications spasms stxbp1 xq28
Tagcloud (Difference) ?			16p12 2q24 5q14 9q34 aetiology caln1 cdkl5 cgh cnv cnvs counselling ehmt1 encephalopathies encompassing epileptic etiological grin2a hypsarrhythmia infantile intronic iss kcnq2 magi2 mef2c microdeletions microduplications spasms stxbp1 xq28
Tagcloud (Intersection) ?