RNF130 and ARPC4

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		RNF130	ARPC4
Gene Name		ring finger protein 130	actin related protein 2/3 complex, subunit 4, 20kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Integral Component Of Membrane	Cytosol Arp2/3 Protein Complex Cell Projection Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity	Structural Constituent Of Cytoskeleton Protein Binding Enzyme Binding Protein Binding, Bridging Actin Filament Binding
	Biological Process	Apoptotic Process Programmed Cell Death Protein Ubiquitination	Axon Guidance Actin Filament Polymerization Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Actin Nucleation Innate Immune Response Ephrin Receptor Signaling Pathway
Pathways			EPHB-mediated forward signaling Axon guidance EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS		Coronary heart disease ( 21347282)
Protein-Protein Interactions		13 interactors: ARPC4 FGFR3 SCN2A TGFBR1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2Z	10 interactors: ACTR2 ACTR3 ARPC1B ARPC2 ARPC3 ARPC5 ARPC5L NELFCD PNMA5 RNF130
Entrez ID		55819	10093
HPRD ID		11504	10368
Ensembl ID		ENSG00000113269	ENSG00000241553
Uniprot IDs		J3KN31 Q2HIY3 Q59EL1 Q86XS8	P59998
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Toll-like Receptor 4 Signaling Pathway Regulation Of Protein Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Immune Response-regulating Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Activation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Cellular Protein Modification Process Regulation Of DNA-templated Transcription In Response To Stress TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Innate Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Innate Immune Response Regulation Of Immune Response Regulation Of Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Regulation Of Innate Immune Response Modification-dependent Protein Catabolic Process Cellular Response To Hypoxia Protein K11-linked Ubiquitination Cellular Response To Decreased Oxygen Levels Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Transferase Activity Cellular Protein Catabolic Process Cellular Response To Oxygen Levels Protein Catabolic Process Cellular Protein Metabolic Process Positive Regulation Of Immune Response Protein K63-linked Ubiquitination Transforming Growth Factor Beta Receptor Signaling Pathway Immune Response Regulation Of Immune System Process Negative Regulation Of Mitotic Nuclear Division Defense Response Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Negative Regulation Of Cell Cycle Cellular Macromolecule Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Enzyme Linked Receptor Protein Signaling Pathway	Arp2/3 Complex-mediated Actin Nucleation Actin Nucleation Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Polymerization Positive Regulation Of Protein Complex Assembly Regulation Of Actin Filament Polymerization Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Actin Filament Organization Positive Regulation Of Cellular Component Biogenesis Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Regulation Of Cytoskeleton Organization Ephrin Receptor Signaling Pathway Actin Cytoskeleton Organization Actin Filament-based Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Organelle Organization Phagocytosis Fc Receptor Signaling Pathway Cytoskeleton Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Axon Guidance Meiotic Chromosome Movement Towards Spindle Pole Immune Response-regulating Signaling Pathway Axonogenesis Axon Development Asymmetric Cell Division Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cellular Component Organization Chemotaxis Positive Regulation Of Immune Response Neuron Projection Morphogenesis Endocytosis Meiotic Cytokinesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Innate Immune Response Movement Of Cell Or Subcellular Component Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Immune Response
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