AKAP1 and PRKAR1A

Number of citations of the paper that reports this interaction (PMID 9065479)
55

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		AKAP1	PRKAR1A
Gene Name		A kinase (PRKA) anchor protein 1	protein kinase, cAMP-dependent, regulatory, type I, alpha
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Integral Component Of Membrane	Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Membrane AMP-activated Protein Kinase Complex Neuromuscular Junction Protein Complex Ciliary Base
	Molecular Function	RNA Binding Protein Binding Poly(A) RNA Binding	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Blood Coagulation	Mesoderm Formation Renal Water Homeostasis Energy Reserve Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Water Transport Female Meiotic Division Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Activation Of Protein Kinase A Activity Intracellular Signal Transduction Small Molecule Metabolic Process Innate Immune Response Sarcomere Organization Negative Regulation Of Meiotic Nuclear Division Neurotrophin TRK Receptor Signaling Pathway Regulation Of Insulin Secretion Transmembrane Transport Cardiac Muscle Cell Proliferation Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		Factors involved in megakaryocyte development and platelet production	Signaling by GPCR Ca-dependent events CaM pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Hedgehog 'off' state Integration of energy metabolism Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling DAG and IP3 signaling CaM pathway DAP12 signaling Downstream signaling of activated FGFR DARPP-32 events Glucagon signaling in metabolic regulation Innate Immune System Signaling by PDGF PKA activation in glucagon signalling Calmodulin induced events Signalling by NGF DAP12 interactions PKA-mediated phosphorylation of CREB PLC beta mediated events Vasopressin regulates renal water homeostasis via Aquaporins Opioid Signalling Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events PKA activation Factors involved in megakaryocyte development and platelet production Signaling by Overexpressed Wild-Type EGFR in Cancer Aquaporin-mediated transport Signaling by FGFR EGFR interacts with phospholipase C-gamma Signaling by ERBB2 PKA-mediated phosphorylation of CREB Signaling by EGFR Downstream signal transduction Calmodulin induced events Signaling by Hedgehog PLC-gamma1 signalling Signaling by EGFR in Cancer PKA activation
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: AMY1A APP CAV1 MAATS1 MYCBP PPP1CA PRKAR1A PRKAR1B PRKAR2A PRKAR2B PTPN21	40 interactors: AKAP1 AKAP10 AKAP11 AKAP4 AKAP7 ARFGEF2 BAHD1 C2orf44 C2orf88 CAPN11 CBS CCNE1 CDK2 CDK4 EGFR GRB2 HIVEP1 HLA-A ITGA4 MAPK6 MAPT MYO7A NELL2 PATZ1 PJA2 PLEKHF2 PRKACA PRKAR1B PRKX PRPF40A PYCARD RAF1 RFC2 SET SETD7 SLC2A4 SMAD2 TAB1 WNK1 ZBED1
Entrez ID		8165	5573
HPRD ID		03905	01786
Ensembl ID		ENSG00000121057	ENSG00000108946
Uniprot IDs		B4DN86 Q92667	B2R5T5 K7ER48 P10644 Q68DQ4
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of CAMP-dependent Protein Kinase Activity Regulation Of CAMP-dependent Protein Kinase Activity Activation Of Protein Kinase A Activity Renal Water Homeostasis Cellular Response To Glucagon Stimulus Negative Regulation Of Protein Serine/threonine Kinase Activity Energy Reserve Metabolic Process Water Transport Fluid Transport Multicellular Organismal Water Homeostasis Activation Of Phospholipase C Activity Response To Glucagon Positive Regulation Of Phospholipase C Activity Blood Coagulation Hemostasis Water Homeostasis Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Body Fluid Levels Wound Healing Renal System Process Negative Regulation Of Transferase Activity Energy Derivation By Oxidation Of Organic Compounds Negative Regulation Of Protein Phosphorylation Response To Wounding Regulation Of Protein Kinase Activity Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Negative Regulation Of Phosphorylation Negative Regulation Of Cellular Protein Metabolic Process Generation Of Precursor Metabolites And Energy Chemical Homeostasis Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Insulin Secretion Positive Regulation Of Hydrolase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Peptide Hormone Secretion Neurotrophin Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus	Blood Coagulation Hemostasis Regulation Of Protein Kinase Activity Regulation Of Protein Kinase A Signaling Regulation Of Body Fluid Levels Regulation Of Kinase Activity Intracellular Signal Transduction Wound Healing Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Response To Wounding Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Movement Of Cell Or Subcellular Component Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Phosphorylation Innate Immune Response Cellular Response To Growth Factor Stimulus Cellular Response To Stimulus Regulation Of Protein Phosphorylation Response To Stress Response To Growth Factor Signal Transduction Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Enzyme Linked Receptor Protein Signaling Pathway Activation Of Protein Kinase Activity Activation Of Phospholipase C Activity Cell Motility Regulation Of Phosphorus Metabolic Process Cell Activation Positive Regulation Of Phospholipase C Activity Cellular Response To Organic Substance G1/S Transition Of Mitotic Cell Cycle Signaling Locomotion Cellular Response To Peptide Hormone Stimulus Mitotic Cell Cycle Cell Communication Cellular Response To Peptide Regulation Of Cellular Protein Metabolic Process Cell Cycle Regulation Of Catalytic Activity Positive Regulation Of Phospholipase Activity Heterochromatin Organization
Tagcloud ?		2a akaps bad barbier biol chaturvedi competes contributed dephosphorylates depletion dissociation exist p90 patel phosphatases pka pkarialpha poppleton pp2ac redistribution rsk rsk1 rsk2 rsk3 silenced silencing stringfield subcellular unstimulated	agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Difference) ?		2a akaps bad barbier biol chaturvedi competes contributed dephosphorylates depletion dissociation exist p90 patel phosphatases pka pkarialpha poppleton pp2ac redistribution rsk rsk1 rsk2 rsk3 silenced silencing stringfield subcellular unstimulated	agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Intersection) ?