AKAP1 and PRKAR2B

Number of citations of the paper that reports this interaction (PubMedID 11483602)
0

Data Source:
HPRD (in vitro, in vivo)

		AKAP1	PRKAR2B
Description		A-kinase anchoring protein 1	protein kinase cAMP-dependent type II regulatory subunit beta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane	Cytoplasm Centrosome Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Membrane Dendrite Neuronal Cell Body Dendritic Spine Dendritic Shaft Perinuclear Region Of Cytoplasm Extracellular Exosome Ciliary Base Postsynapse Glutamatergic Synapse
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding Protein Kinase A Regulatory Subunit Binding	Nucleotide Binding CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Kinase Binding Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Apoptotic Process Antiviral Innate Immune Response	Fatty Acid Metabolic Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Learning Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Response To Antipsychotic Drug Negative Regulation Of CAMP/PKA Signal Transduction
Pathways		Mitochondrial calcium ion transport Factors involved in megakaryocyte development and platelet production	PKA activation PKA activation in glucagon signalling DARPP-32 events Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs			Cyclic adenosine monophosphate
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Crohn's disease ( 26192919) Freckles ( 29895819) Inflammatory bowel disease ( 26192919) Male-pattern baldness ( 27182965)	Adverse response to lamotrigine and phenytoin ( 22379998) Bladder cancer (smoking interaction) ( 24662972) Blood urea nitrogen levels ( 31152163) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196) Manganese levels ( 26025379) Response to antipsychotic treatment ( 20195266) Triglyceride levels ( 32203549)
Interacting Genes		12 interacting genes: AMY1A CAV1 CFAP91 DYSF MYCBP PPP1CA PRKAR1A PRKAR1B PRKAR2A PRKAR2B PTPN21 RNF10	17 interacting genes: AKAP1 AKAP10 AKAP11 AKAP14 AKAP19 AKAP4 AKAP5 AKAP9 CFAP91 ECM1 GNAI3 KIF5B LASP1 NBEA OGT PAK1IP1 TAF12
Entrez ID		8165	5577
HPRD ID		03905	01486
Ensembl ID		ENSG00000121057	ENSG00000005249
Uniprot IDs		A0A140VK05 B4DN86 Q92667	B3KY43 P31323
PDB IDs
Enriched GO Terms of Interacting Partners?		CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Regulator Activity CAMP-dependent Protein Kinase Inhibitor Activity Ciliary Base Protein Kinase A Catalytic Subunit Binding CAMP Binding Negative Regulation Of CAMP/PKA Signal Transduction Regulation Of CAMP/PKA Signal Transduction Nucleotide-activated Protein Kinase Complex Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Glutamatergic Synapse Axoneme Plasma Membrane Raft Negative Regulation Of Intracellular Signal Transduction G Protein-coupled Receptor Signaling Pathway Protein Domain Specific Binding Postsynapse Cellular Response To Glucagon Stimulus Ubiquitin Protein Ligase Binding Response To Glucagon Cellular Response To Peptide Hormone Stimulus Negative Regulation Of Signal Transduction Modulation Of Chemical Synaptic Transmission Negative Regulation Of Signaling Negative Regulation Of Cell Communication Mesoderm Formation Multivesicular Body Regulation Of Vesicle-mediated Transport Positive Regulation Of Glucose Metabolic Process Regulation Of System Process Inward Rectifier Potassium Channel Inhibitor Activity Monocyte Activation Involved In Immune Response Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Formation Of Primary Germ Layer Regulation Of Carbohydrate Catabolic Process Centrosome Negative Regulation Of Endocytosis Alpha-amylase Activity Caveolar Macromolecular Signaling Complex Regulation Of Cell Communication Response To Peptide Hormone Regulation Of Signaling Regulation Of Endocytosis RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Response To Antipsychotic Drug Radial Spoke Stalk Neuromuscular Junction Regulation Of Cardiac Muscle Contraction Regulation Of Small Molecule Metabolic Process	Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding Negative Regulation Of Adenylate Cyclase Activity CAMP-dependent Protein Kinase Complex
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